Polycyclic aromatic hydrocarbons inhibit in vitro ovarian steroidogenesis in the flounder (Platichthys flesus L.)

Monteiro, Pedro Ribeiro Rocha; Reis-Henriques, M.A.; Coimbra, Joaquim Luís

doi:10.1016/s0166-445x(99)00055-7

Cited by 142 publications

(67 citation statements)

References 36 publications

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“…In rats, BAP (5 and 10 mg/kg) has been shown to decrease levels of E 2 and decrease aromatase mRNA and protein (Xu et al 2010). Furthermore, BAP, phenanthrene, and chrysene inhibited androstenedione and E 2 secretion by ovarian tissues of flounder treated with each chemical individually at 15 mM (Monteiro et al 2000, Rocha Monterio et al 2000 and phenanthrenequinone (100-1000 nM), a metabolite of phenanthrene, reduced LH-stimulated progesterone in rat luteal cells (Nykamp et al 2001). Despite the limited data currently available, the influence of PAHs on steroidogenesis is evident and, thus, it is reasonable to predict that studies aimed at understanding their mechanisms of action are forthcoming.…”

Section: Polycyclic Aromatic Hydrocarbonsmentioning

confidence: 95%

Endocrine-disrupting chemicals in ovarian function: effects on steroidogenesis, metabolism and nuclear receptor signaling

Craig¹,

Wang²,

Flaws³

2011

Reproduction

211

109

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Endocrine-disrupting chemicals (EDCs) are exogenous agents with the ability to interfere with processes regulated by endogenous hormones. One such process is female reproductive function. The major reproductive organ in the female is the ovary. Disruptions in ovarian processes by EDCs can lead to adverse outcomes such as anovulation, infertility, estrogen deficiency, and premature ovarian failure among others. This review summarizes the effects of EDCs on ovarian function by describing how they interfere with hormone signaling via two mechanisms: altering the availability of ovarian hormones, and altering binding and activity of the hormone at the receptor level. Among the chemicals covered are pesticides (e.g. dichlorodiphenyltrichloroethane and methoxychlor), plasticizers (e.g. bisphenol A and phthalates), dioxins, polychlorinated biphenyls, and polycyclic aromatic hydrocarbons (e.g. benzo[a]pyrene).

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Section: Polycyclic Aromatic Hydrocarbonsmentioning

confidence: 95%

Endocrine-disrupting chemicals in ovarian function: effects on steroidogenesis, metabolism and nuclear receptor signaling

Craig¹,

Wang²,

Flaws³

2011

Reproduction

211

109

View full text Add to dashboard Cite

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“…Many PAH compounds and the intermediates that emerge during metabolic degradation exhibit toxic properties (e.g., narcosis, phototoxicity, immunotoxicity, teratogenicity, and carcinogenicity) and can cause a wide range of adverse health effects in fish, invertebrates, and other marine life (e.g., Peterson et al, 2003). Adverse effects on these organisms include the formation of liver tumors (e.g., in North Sea flatfish flounder and dab; Vethaak et al, , 2009Myers et al, 2003), impairment of reproduction (reviewed by Nicolas, 1999;Rocha Monteiro et al, 2000), embryonic deformities (Carls et al, 2008), and immune modulation (e.g., Reynaud and Deschaux, 2006). Consequently, PAHs constitute a major threat to marine life and are therefore included in the list of chemicals for priority action by the Oslo Paris Convention for the protection of the marine environment of the NorthEast Atlantic (OSPAR, 2001).…”

Section: Introductionmentioning

confidence: 99%

Decadal Trends in Polycyclic Aromatic Hydrocarbon (PAH) Contamination Assessed by 1-Hydroxypyrene in Fish Bile Fluid in the Netherlands: Declining in Marine Waters but Still a Concern in Estuaries

Vethaak

Baggelaar

Lieverloo³

et al. 2016

Front. Mar. Sci.

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Long-term monitoring data on the concentrations of biliary 1-hydroxypyrene (1-OHPyr) in flatfish, as a biomarker for polycyclic aromatic hydrocarbon (PAH) exposure, were analyzed and evaluated to elucidate spatial differences and temporal trends in marine and estuarine PAH contamination in the Netherlands. Dab (Limanda limanda) and flounder (Platichthys flesus) with partly overlapping distributions were used as target species. In total 1831 bile samples were analyzed individually: 417 dab in 1998-2005 and 1438 flounder in 1996-2012. The sampling procedure for flatfish and the PAH metabolites determination by means of high performance liquid chromatography (HPLC) with fluorescence (FL) detection were based on international guidelines. Measuring the absorbance at 380 nm was tested to correct for possible differences in feeding status, but this turned out not to be a suitable parameter for the standardization of PAH metabolite concentrations. Both fish species showed statistically significant differences in biliary 1-OHPyr concentrations between various locations. The highest level of PAH contamination was found in flounder from the estuarine Western Scheldt, which might be partly due to local dredging activities. Dab from the central North Sea (Dogger Bank) showed the lowest level of PAH contamination. Analysis of all the data indicated mainly downward trends in PAH contamination, most clearly pronounced in the Dutch Wadden Sea. PAH exposure levels in the Dutch coastal waters including the Eastern Scheldt and the Wadden Sea, and also at the offshore North Sea monitoring sites represent levels of response that are not indicative of significant harm. In contrast, PAH contamination in the more industrialized Dutch estuaries (Western Scheldt and Ems-Dollard) is still a cause Vethaak et al.Marine and Estuarine PAH Contamination for concern. Future monitoring should register the total bile volume, the sex of the fish and the method of fishing to improve the interpretation of the data. In addition, the biliary absorbance at 380 nm should be registered as it may help the interpretation of outliers in the data.

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“…Many polycyclic aromatic compounds are toxic to humans and other organisms. Extensive literature persists describing the effects of PAHs on animals, including fish (Monteiro et al, 2000;Incardona et al, 2004;. Endocrine disruption is one of these effects.…”

Section: Introductionmentioning

confidence: 99%

“…Endocrine disruption is one of these effects. Monteiro et al (2000) reported that PAHs inhibit ovarian steroidogenesis in flounders by strongly blocking the activity of CYP 17, 20 lyase (Monterio et al, 2000). However, the most well-known attribute of PAHs is their toxicity.…”

Section: Introductionmentioning

confidence: 99%

Characterization of phase-II conjugation reaction of polycyclic aromatic hydrocarbons in fish species: Unique pyrene metabolism and species specificity observed in fish species

Ikenaka

Oguri

Saengtienchai

et al. 2013

Environmental Toxicology and Pharmacology

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Metabolic activity, particularly conjugation, was examined in fish by analyzing pyrene (a four-ring, polycyclic aromatic hydrocarbon) metabolites using high-performance liquid chromatography (HPLC) with fluorescence detector (FD), a mass spectrometry (MS) system, and kinetic analysis of conjugation enzymes. Fourteen fresh water fish species, including Danio rerio and Orizias latipes, were exposed to aqueous pyrene, and the resulting metabolites were collected. Identification of pyrene metabolites by HPLC/FD and ion-trap MS indicated that the major metabolites were pyrene glucuronide and pyrene sulfate in all 14 species. Differences were observed in pyrene glucuronide:pyrene sulfate ratio and in the total amount of pyrene conjugates excreted between fish species. Furthermore, a correlation was found between the amount of pyrene glucuronide present and the total amount of the pyrene metabolite eliminated.Kinetic analysis of conjugation by hepatic microsomes in vitro indicated that the differences in excreted metabolites reflected the differences in enzymatic activities.

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Polycyclic aromatic hydrocarbons inhibit in vitro ovarian steroidogenesis in the flounder (Platichthys flesus L.)

Cited by 142 publications

References 36 publications

Endocrine-disrupting chemicals in ovarian function: effects on steroidogenesis, metabolism and nuclear receptor signaling

Endocrine-disrupting chemicals in ovarian function: effects on steroidogenesis, metabolism and nuclear receptor signaling

Decadal Trends in Polycyclic Aromatic Hydrocarbon (PAH) Contamination Assessed by 1-Hydroxypyrene in Fish Bile Fluid in the Netherlands: Declining in Marine Waters but Still a Concern in Estuaries

Characterization of phase-II conjugation reaction of polycyclic aromatic hydrocarbons in fish species: Unique pyrene metabolism and species specificity observed in fish species

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