Polycyclic aromatic hydrocarbons exposure and lung function decline among coke-oven workers: A four-year follow-up study

Wang, Suhan; Bai, Yansen; Deng, Qifei; Chen, Zhuowang; Dai, Juanxiu; Li, Xiaoliang; Zhang, Wangzhen; Zhang, Xiaomin; He, Meian; Wu, Tangchun; Guo, Huan

doi:10.1016/j.envres.2016.05.025

Cited by 54 publications

(26 citation statements)

References 40 publications

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“…PAH exposure has been linked to adverse respiratory health outcomes in children, including bronchitis [ 56 , 57 ] and reductions in the forced expiratory volume, (FEV 1 ) [ 58 – 62 ]. Among adults in occupational settings, elevated PAH exposures have been found to be associated with declines in FEV 1 /forced vital capacity (FVC) [ 63 ]. In an in vitro animal cell model, low molecular weight PAHs and benzo[a]pyrene (which are found together in cigarette smoke) elicited increased carcinogenic potential [ 64 ].…”

Section: Methodsmentioning

confidence: 99%

Pollution and respiratory disease: can diet or supplements help? A review

et al. 2018

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Pollution is known to cause and exacerbate a number of chronic respiratory diseases. The World Health Organisation has placed air pollution as the world’s largest environmental health risk factor. There has been recent publicity about the role for diet and anti-oxidants in mitigating the effects of pollution, and this review assesses the evidence for alterations in diet, including vitamin supplementation in abrogating the effects of pollution on asthma and other chronic respiratory diseases. We found evidence to suggest that carotenoids, vitamin D and vitamin E help protect against pollution damage which can trigger asthma, COPD and lung cancer initiation. Vitamin C, curcumin, choline and omega-3 fatty acids may also play a role. The Mediterranean diet appears to be of benefit in patients with airways disease and there appears to be a beneficial effect in smokers however there is no direct evidence regarding protecting against air pollution. More studies investigating the effects of nutrition on rapidly rising air pollution are urgently required. However it is very difficult to design such studies due to the confounding factors of diet, obesity, co-morbid illness, medication and environmental exposure.

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Section: Methodsmentioning

confidence: 99%

Pollution and respiratory disease: can diet or supplements help? A review

et al. 2018

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“…The studies included in this review showed evidence that exposure to PAH was associated with the presence of cardiovascular diseases and aggravations, such as increased blood pressure levels (22) , heart rate variation (14,(24)(25)(26) and ischemic heart disease (17,20,27) ; and respiratory diseases such as reduced lung function (23) , chronic obstructive pulmonary disease (COPD) (18)(19)28) , asthma (19) , and symptoms such as wheezing (16) , cough (16,18) , lung wheezing (19), tight chest (19) , shortness of breath on exertion (19) and sore throat (16) .…”

Section: Discussionmentioning

confidence: 99%

“…It was verified that there was difference in the pulmonary function among PAH-exposed workers, i.e. effects of decline over the years (23) , for they present with more respiratory symptoms, lower lung function and signs of airway inflammation, even at low levels of exposure (15) .…”

Section: Polycyclic Aromatic Hydrocarbons and Development Of Respiratmentioning

confidence: 97%

“…Polycyclic aromatic hydrocarbons exposure and lung function decline among coke-oven workers: a four-year follow up study (23) .…”

Section: China Web Of Sciencementioning

confidence: 99%

“…Cytokines and other substances secreted by inflammatory cells are the factors that contribute to airway inflammation and lung function decline through the development of structural changes of the airways (23) .…”

Section: Polycyclic Aromatic Hydrocarbons and Development Of Respiratmentioning

confidence: 99%

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Polycyclic aromatic hydrocarbons and development of respiratory and cardiovascular diseases in workers

et al. 2020

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Objectives: to identify the scientific evidence on the development of cardiovascular and respiratory diseases due to workplace contamination by polycyclic aromatic hydrocarbons. Methods: integrative literature review. The search for primary articles was held in October 2017 in the Medical Literature Analysis and Retrieval System Online (through Pubmed), Web of Science and Latin American and Caribbean Literature in Health Sciences (LILACS). Results: the 16 studies analyzed showed that exposure to polycyclic aromatic hydrocarbons was associated with cardiovascular diseases, such as increased blood pressure, heart rate variation, and ischemic heart disease; and respiratory disorders, such as decreased lung function, chronic obstructive pulmonary disease, asthma, wheeze, coughing, pulmonary wheezing, chest tightness, effort dyspnea, and sore throat. Conclusions: polycyclic aromatic hydrocarbons cause deleterious effects on the cardiovascular and respiratory systems through mutations and cellular inflammation, being a risk to exposed individuals.

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