Polycyclic aromatic hydrocarbons and PAH-related DNA adducts

Abstract

Investigations on the impact of chemicals on the environment and human health have led to the development of an exposome concept. The exposome refers to the totality of exposures received by a person during life, including exposures to life-style factors, from the prenatal period to death. The exposure to genotoxic chemicals and their reactive metabolites can induce chemical modifications of DNA, such as, for example, DNA adducts, which have been extensively studied and which play a key role in chemically induced carcinogenesis. Development of different methods for the identification of DNA adducts has led to adopting DNA adductomic approaches. The ability to simultaneously detect multiple PAH-derived DNA adducts may allow for the improved assessment of exposure, and offer a mechanistic insight into the carcinogenic process following exposure to PAH mixtures. The major advantage of measuring chemical-specific DNA adducts is the assessment of a biologically effective dose. This review provides information about the occurrence of the polycyclic aromatic hydrocarbons (PAHs) and their influence on human exposure and biological effects, including PAH-derived DNA adduct formation and repair processes. Selected methods used for determination of DNA adducts have been presented.

Microbial responses to anthropogenic dissolved organic carbon in the Arctic and Antarctic coastal seawaters

“…4 and Supporting Information Fig. PAHs, particularly benzo[a]pyrene, and other hydrophobic chemicals, such as chlorinated aliphatic compounds, can inhibit cell growth through the formation of DNA-PAH adducts (Kabelitz et al, 2003;Ewa and Danuta, 2017). PAHs, particularly benzo[a]pyrene, and other hydrophobic chemicals, such as chlorinated aliphatic compounds, can inhibit cell growth through the formation of DNA-PAH adducts (Kabelitz et al, 2003;Ewa and Danuta, 2017).…”

“…S4), indicating a harmful effect of ADOC compounds to the community. PAHs, particularly benzo[a]pyrene, and other hydrophobic chemicals, such as chlorinated aliphatic compounds, can inhibit cell growth through the formation of DNA-PAH adducts (Kabelitz et al, 2003;Ewa and Danuta, 2017). For instance, PAHs have been identified as inducing phytotoxicity to Prochlorococcus by reducing DNA synthesis and delaying cell division (Cerezo and Agustí, 2015).…”

Effects of phenanthrene on oxidative stress and inflammation in lung and liver of female rats

“…Polycyclic aromatic hydrocarbons (PAHs), as the gas‐phase‐air pollutant attached in PM, are a group of organic compounds with two or more fused aromatic rings that are produced from incomplete combustion, pyrolysis of organic substances, and release of petroleum products . Such PAHs widespread occurrence in air, water, soil plants as well as in animals, and impact on human health via different ways …”

BaP exposure causes oocyte meiotic arrest and fertilization failure to weaken female fertility

“…Human activities such as industrial production, transportation, coal combustion, and sulfur dioxide emissions release various poisonous and harmful substances (2,3), which are atmospherically transported and deposited in urbanized areas where people live and work (4)(5)(6)(7). Among the large amounts of pollutants present in the cities, polycyclic aromatic hydrocarbons (PAHs) have attracted a great deal of attention because of their toxicity and persistence, which threaten human health and cause adverse disease effects (8)(9)(10), including reproductive defects (11)(12)(13). In the air, PAHs emitted from solid fuel combustion, like other volatile and semivolatile pollutants, adsorb on the suspended particulate matter (PM), a complex mixture of extremely small particles and liquid droplets made up of a carbonaceous fraction and inorganic constituents (14), to form the main elements threatening human health in smog, especially the health of susceptible populations, such as pregnant women and children (8).…”