Polycyclic aromatic hydrocarbon (PAH) composition of mesquite (Prosopis fuliflora) smoke and grilled beef

Maga, Joseph A.

doi:10.1021/jf00068a023

Cited by 28 publications

(27 citation statements)

References 14 publications

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“…We have chosen BaP and FLA for this study because both were widespread toxicants as shown for cell culture systems (Le Hégarat et al, 2012; Wessel et al, 2012) and animal models (Knuckles et al, 2001, 2004). Additionally, the concentrations of BaP and FLA in meat products and agricultural produce (Maga, 1986; Ramesh et al, 2004) and their mean dietary intake (Martí-Cid et al, 2008) were reported to be higher than the other PAHs. While BaP is classified as a carcinogen (IPCS, 1998), FLA is considered as a non-classifiable carcinogen (EPA, 2001).…”

Section: Introductionmentioning

confidence: 99%

Benzo(a)pyrene modulates fluoranthene-induced cellular responses in HT-29 colon cells in a dual exposure system

Harris

Myers

Ramesh

2013

Environmental Toxicology and Pharmacology

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Our environment is contaminated with a diverse array of chemicals; one of which is polycyclic aromatic hydrocarbons (PAHs). While some PAHs are potent by nature, others undergo interactions such as additivity, synergism, antagonism or potentiation to manifest their toxicity. Therefore, the objective of this study was to investigate whether exposure to benzo(a)pyrene (BaP), a PAH compound influences the cytotoxicity and metabolism of fluoranthene (FLA; another PAH compound) using HT-29 cells. Cells cultured in Dulbecco's Modified Eagle Medium were treated with 1, 5, 10, 25 μM BaP and FLA (0.01% dimethylsulfoxide as vehicle) individually and in combination over the course of 0–96 h. At the end of exposure, cells were stained with propidium iodide and the changes in cell cycle were analyzed using FACS analysis. Apoptosis was determined by caspase-3 assay. Post-incubation, samples were extracted and analyzed for FLA metabolites by reverse-phase HPLC with fluorescence detection. Cells exposed to BaP + FLA showed a marginal decrease in growth as compared to FLA alone and vehicle controls. Also, a decline in the percentage of cells in the S and G2 phases compared to G1 phase of cell cycle was noted when cells were treated with BaP and FLA together, compared to individual FLA treatment. The rate of FLA metabolism was more when cells were exposed to FLA in combination with BaP, compared to FLA alone. The enhanced biotransformation of FLA as a result of concomitant exposure to BaP may have implications for colon cancer risks arising from human dietary exposure to PAH mixtures through consumption of barbecued meat.

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Section: Introductionmentioning

confidence: 99%

Benzo(a)pyrene modulates fluoranthene-induced cellular responses in HT-29 colon cells in a dual exposure system

Harris

Myers

Ramesh

2013

Environmental Toxicology and Pharmacology

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“…Many reports have demonstrated that carcinogenic PAHs can be formed through grilling and smoking of foods (Lijinsky and Ross, 1967;Doremire et al, 1979;Afolabi et al, 1983;Maga, 1986;Nico et al, 1987;Gomaa et al, 1993;Chen et al, 1996). The formation of various PAHs profiles during smoking can be dependent upon temperature, time, smoke composition, moisture content of wood and the presence of oxygen (Fretheim et al, 1980).…”

Section: Introductionmentioning

confidence: 99%

Formation of Polycyclic Aromatic Hydrocarbons during Processing of Duck Meat

Chen

Lin

1997

J. Agric. Food Chem.

130

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The effects of various processing methods, steaming, roasting, smoking, charcoal grilling, and liquid smoke flavoring (LSF), on the formation of polycyclic aromatic hydrocarbons (PAHs) in duck breast steak were studied. The various PAHs in the duck samples were analyzed by gas chromatography with ion-trap detection. Results showed that with processing time from 0.5 to 1.5 h, charcoal grilling of duck samples with skin contained the highest amount of total PAHs, followed by charcoal grilling of duck samples without skin, smoking, roasting, steaming, and LSF. For carcinogenic PAHs, smoking contained the highest amount, followed by charcoal grilling and roasting. No carcinogenic PAHs were observed for steaming and LSF-treated duck samples. Also, the highest amounts of both total and carcinogenic PAHs were found after smoking duck samples for 3 h.

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“…THE SMOKE CONDENSATES were generated using the method described by Maga (1986), and Maga and Fapojuwo (1986). A total of 20 condensates derived from 20 different types of wood were examined.…”

Section: Methodsmentioning

confidence: 99%

“…Natural wood smoking of food has been to some degree replaced in recent years by use of liquid smoke flavorings. Use of liquid smoke minimizes pollution problems and should be free of polycyclic aromatic hydrocarbons which are potential carcinogens (Maga, 1986). Liquid smoke also offers use of controlled concentrations for uniformity in application and flavor.…”

mentioning

confidence: 99%

Effect of Ether Extracts from Condensed Wood Smokes on the Growth of Aeromonas hydrophila and Staphylococcus aureus

Sofos

Maga

Boyle

1988

Journal of Food Science

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Ether extracts of smoke condensates ("liquid smokes") from 20 different woods were screened for antimicrobial activity. Testing was done in trypticase soy broth of pH values in the range of 5.78-6.81 against three strains each of Aeromonns hydrophilu (ATCC 7965, K1414, BW37) and Sfaphylococcus aureus (ATCC 12600, LP, S6) incubated at 35°C. There was variation in inhibition of growth among types of liquid smoke, species, and strains of microorganisms tested. Staphylococcus uureus was generally more sensitive to inhibition than A. hydrophilu strains. The most inhibitory liquid smoke was derived from the sapwood of douglas fir. Other inhibitory liquid smokes were from birch, southern yellow pine, and aspen. The least inhibitory liquid smokes were derived from Iodge pole pine and mesquite woods.

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Polycyclic aromatic hydrocarbon (PAH) composition of mesquite (Prosopis fuliflora) smoke and grilled beef

Cited by 28 publications

References 14 publications

Benzo(a)pyrene modulates fluoranthene-induced cellular responses in HT-29 colon cells in a dual exposure system

Benzo(a)pyrene modulates fluoranthene-induced cellular responses in HT-29 colon cells in a dual exposure system

Formation of Polycyclic Aromatic Hydrocarbons during Processing of Duck Meat

Effect of Ether Extracts from Condensed Wood Smokes on the Growth of Aeromonas hydrophila and Staphylococcus aureus

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