Polycrystalline Diamond as a Potential Material for the Hard-on-Hard Bearing of Total Hip Prosthesis: Von Mises Stress Analysis

Ammarullah, Muhammad Imam; Hartono, R. W. Tri; Supriyono, Toto; Santoso, Gatot; Sugiharto, S.; Permana, Muki Satya

doi:10.3390/biomedicines11030951

Cited by 93 publications

(73 citation statements)

References 59 publications

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“…As biocompatibility is one of the most important aspects in the design of implantable devices [ 30 ], including tissue-engineered products, polycaprolactone (PCL) was preferred in the fabrication of the scaffolds due to its proven track record in the biomedical applications. PCL, a semi-crystalline biodegradable polymer belonging to the aliphatic polyester family, has shown great potential in medical applications, tissue engineering, and drug delivery, and has already been used in several medical devices approved by the FDA [ 31 , 32 ].…”

Section: Resultsmentioning

confidence: 99%

Microporous/Macroporous Polycaprolactone Scaffolds for Dental Applications

et al. 2023

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This study leverages the advantages of two fabrication techniques, namely, melt-extrusion-based 3D printing and porogen leaching, to develop multiphasic scaffolds with controllable properties essential for scaffold-guided dental tissue regeneration. Polycaprolactone–salt composites are 3D-printed and salt microparticles within the scaffold struts are leached out, revealing a network of microporosity. Extensive characterization confirms that multiscale scaffolds are highly tuneable in terms of their mechanical properties, degradation kinetics, and surface morphology. It can be seen that the surface roughness of the polycaprolactone scaffolds (9.41 ± 3.01 µm) increases with porogen leaching and the use of larger porogens lead to higher roughness values, reaching 28.75 ± 7.48 µm. Multiscale scaffolds exhibit improved attachment and proliferation of 3T3 fibroblast cells as well as extracellular matrix production, compared with their single-scale counterparts (an approximate 1.5- to 2-fold increase in cellular viability and metabolic activity), suggesting that these structures could potentially lead to improved tissue regeneration due to their favourable and reproducible surface morphology. Finally, various scaffolds designed as a drug delivery device were explored by loading them with the antibiotic drug cefazolin. These studies show that by using a multiphasic scaffold design, a sustained drug release profile can be achieved. The combined results strongly support the further development of these scaffolds for dental tissue regeneration applications.

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Section: Resultsmentioning

confidence: 99%

Microporous/Macroporous Polycaprolactone Scaffolds for Dental Applications

et al. 2023

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“…This helped us predict the clinical outcome of these blocks upon manual manipulation. Following the recommendations of this paper, future computational studies can be designed to predict the best possible parameters of processing bone grafts to produce maximum strength of the bone blocks [ 46 , 47 , 48 ].…”

Section: Discussionmentioning

confidence: 99%

Comparison of Low and High Temperature Sintering for Processing of Bovine Bone as Block Grafts for Oral Use: A Biological and Mechanical In Vitro Study

Elahi

Duncan

et al. 2023

Bioengineering

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Large oral bone defects require grafting of bone blocks rather than granules to give physically robust, biocompatible and osteoconductive regeneration. Bovine bone is widely accepted as a source of clinically appropriate xenograft material. However, the manufacturing process often results in both reduced mechanical strength and biological compatibility. The aim of this study was to assess bovine bone blocks at different sintering temperatures and measure the effects on mechanical properties and biocompatibility. Bone blocks were divided into four groups; Group 1: Control (Untreated); Group 2: Initial boil for 6 h; Group 3: Boil 6 h followed by sintering at 550 °C for 6 h; Group 4: Boil 6 h followed by sintering at 1100 °C for 6 h. Samples were assessed for their purity, crystallinity, mechanical strength, surface morphology, chemical composition, biocompatibility and clinical handling properties. Statistical analysis was performed using one-way ANOVA and post-hoc Tukey’s tests for normally distributed and Friedman test for abnormally distributed quantitative data from compression tests and PrestoBlue™ metabolic activity tests. The threshold for statistical significance was set at p < 0.05. The results showed that higher temperature sintering (Group 4) removed all organic material (0.02% organic components and 0.02% residual organic components remained) and increased crystallinity (95.33%) compared to Groups 1–3. All test groups (Group 2–4) showed decreased mechanical strength (MPa: 4.21 ± 1.97, 3.07 ± 1.21, 5.14 ± 1.86, respectively) compared with raw bone (Group 1) (MPa: 23.22 ± 5.24, p <0.05), with micro-cracks seen under SEM in Groups 3 and 4. Group 4 had the highest biocompatibility (p < 0.05) with osteoblasts as compared to Group 3 at all time points in vitro. Clinical handling tests indicated that Group 4 samples could better withstand drilling and screw placement but still demonstrated brittleness compared to Group 1. Hence, bovine bone blocks sintered at 1100 °C for 6 h resulted in highly pure bone with acceptable mechanical strength and clinical handling, suggesting it is a viable option as a block grafting material.

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“…The von Mises stress is often used in determining whether an isotropic and ductile metal will fracture when subjected to a complex loading condition. 57 This is carried out by computing the von Mises stress and comparing it to the yield stress of the material, also known as the von Mises yield criterion. 58 The von Mises stress criterion is depicted by Figure 4b−e.…”

Section: ■ Experimental Detailsmentioning

confidence: 99%

Enhancing Bone Implants: Magnesium-Doped Hydroxyapatite for Stronger, Bioactive, and Biocompatible Applications

Bhatnagar,

Gautam,

Sonowal

et al. 2024

ACS Appl. Bio Mater.

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Hydroxyapatite (HAp) with the chemical formula Ca 10 (PO 4 ) 6 (OH) 2 is an inorganic material that exhibits morphology and composition similar to those of human bone tissues, making it highly desirable for bone regeneration applications. As one of the most biocompatible materials currently in use, HAp has undergone numerous attempts to enhance its mechanical strength. This research focuses on investigating the influence of magnesium (Mg) incorporation on the structural and mechanical properties of synthesized magnesium-doped hydroxyapatite (MgHAp) samples. Apart from its biocompatibility, Mg possesses a density and elasticity comparable to those of human bone. Therefore, incorporating Mg into HAp can be pivotal for improving bone formation. Previous studies have not extensively explored the structural changes induced by Mg substitution in HAp, which motivated us to revisit this issue. Hydrothermal synthesis technique was used to synthesize MgHAp samples with varying molar concentrations (x = 0, 0.5, 1.0, and 1.5). Theoretical simulation of HAp and MgHAp for obtaining 3D structures has been done, and theoretical X-ray diffraction (XRD) data have been compared with the experimental XRD data. Rietveld analysis revealed the alteration and deviation of lattice parameters with an increase in the Mg content, which ultimately affect the structure as well the mechanical properties of prepared samples. The findings revealed an increase in compressive stress and fracture toughness as the Mg concentration in the composition increased. Furthermore, using a finite-element analysis technique and modeling of the mechanical testing data, the von Mises stress distribution and Young's modulus values were calculated, demonstrating the similarity of the prepared samples to human cortical bone. Biocompatibility assessments using NIH-3T3 fibroblast cells confirmed the biocompatible and bioactive nature of the synthesized samples. MgHAp exhibits great potential for biomedical applications in the dental, orthopedic, and tissue engineering research fields.

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Polycrystalline Diamond as a Potential Material for the Hard-on-Hard Bearing of Total Hip Prosthesis: Von Mises Stress Analysis

Cited by 93 publications

References 59 publications

Microporous/Macroporous Polycaprolactone Scaffolds for Dental Applications

Microporous/Macroporous Polycaprolactone Scaffolds for Dental Applications

Comparison of Low and High Temperature Sintering for Processing of Bovine Bone as Block Grafts for Oral Use: A Biological and Mechanical In Vitro Study

Enhancing Bone Implants: Magnesium-Doped Hydroxyapatite for Stronger, Bioactive, and Biocompatible Applications

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