Polycomponent drugs in the treatment of intertriginous dermatosis

Abstract

The most common localization of dermatoses of combined etiology are intertriginous areas. In recent years, an increase in the number of patients suffering from dermatoses of combined etiology has been recorded. The reasons for this situation can be both irrational therapy and background comorbidities in the patient, as well as a number of anatomical and physiological prerequisites for the formation and maintenance of an inflammatory infectious process with localization, namely in the area of skin folds. The article describes in detail the anatomical and physiological features of these areas, the causes of the development of dermatosis of the combined etiology of the fold area. Epidemiological and statistical data on the distribution of a combination of acute, chronic, infectious and non-infectious dermatoses, the causes and frequency of their occurrence are given. Particular attention is paid to the microbiocenosis of the skin in various dermatoses with an emphasis on intertriginous localizations. Approaches to the treatment of such conditions involve the use of combined external agents containing topical corticosteroids, antimicrobial and antifungal components. The article presents data available in the literature on the effectiveness of the use of a multicomponent preparation – Tetraderm cream (consisting of an antibiotic-aminoglycoside + tissue repair stimulant + GCS for local use + an antifungal agent – econazole nitrate) for various dermatoses localized in intertriginous areas. We present our own clinical observations of the effectiveness of the use of this polycomponent preparation Tetraderm in the treatment of patients with skin lesions of combined etiology in the area of folds in atopic dermatitis, allergic dermatitis, mycotic, staphylo-streptococcal infections occurring in combination.