Polyclonal immunoglobulin recovery in patients with newly diagnosed myeloma receiving maintenance therapy after autologous haematopoietic stem cell transplantation with either carfilzomib, lenalidomide and dexamethasone or lenalidomide alone: Subanalysis of the randomized phase 3 ATLAS trial
Tadeusz Kubicki,
Dominik Dytfeld,
Tomasz Wróbel
et al.
Abstract:SummaryPrevious studies suggest that postautologous stem cell transplant (ASCT) recovery of polyclonal immunoglobulin from immunoparesis in patients with multiple myeloma is a positive prognostic marker. We performed a longitudinal analysis of polyclonal immunoglobulin concentrations and unique B‐cell sequences in patients enrolled in the phase 3 ATLAS trial that randomized 180 subjects to either carfilzomib, lenalidomide, dexamethasone (KRd) or lenalidomide (R) maintenance. In the KRd arm, standard‐risk patie… Show more
“…In their paper the authors 1 reported recovery of polyclonal immunoglobulins in multiple myeloma (MM) patients after autologous stem cell transplantation (ASCT) and initial immunoparesis in the ATLAS phase III study that compared KRD (carfilzomib, lenalidomide and dexamethasone) and R (lenalidomide) as maintenance therapy. The authors found that patients in the R arm recovered a polyclonal status more than patients in the KRD arm.…”
How to cite this article: Gozzetti A, Bernareggi I, Sammartano V. Finding the balance between immunoparesis recovery and multiple myeloma responses after autologous stem cell transplantation in the era of maintenance therapy and novel drugs.
“…In their paper the authors 1 reported recovery of polyclonal immunoglobulins in multiple myeloma (MM) patients after autologous stem cell transplantation (ASCT) and initial immunoparesis in the ATLAS phase III study that compared KRD (carfilzomib, lenalidomide and dexamethasone) and R (lenalidomide) as maintenance therapy. The authors found that patients in the R arm recovered a polyclonal status more than patients in the KRD arm.…”
How to cite this article: Gozzetti A, Bernareggi I, Sammartano V. Finding the balance between immunoparesis recovery and multiple myeloma responses after autologous stem cell transplantation in the era of maintenance therapy and novel drugs.
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