Polyclonal Campylobacter fetus Infections Among Unrelated Patients, Montevideo, Uruguay, 2013–2018

Costa, Daniela; Betancor, Laura; Gadea, Pilar; Cabezas, Laura; Caiata, Leticia; Palacio, Rosario; Seija, Verónica; Galiana, Antonio; Vieytes, Mariela; Cristophersen, Inés; Calleros, Lucía; Iraola, Gregorio

doi:10.1093/cid/ciz657

Cited by 4 publications

(5 citation statements)

References 12 publications

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“…The zoonosis through the food chain (mainly products from cattle and sheep) has been assumed to be the most probable route of transmission (Wagenaar et al 2014). Nevertheless, other studies suggest person-to-person transmission through sexual contact or by mother to newborn, and from newborn to another newborn (Costa et al 2020). Recently, Iraola et al (2017) argued that there are different host-adapted lineages, mainly human and bovine, and that C. fetus may be a human intestinal pathobiont, as it was detected in the faecal metagenome of healthy individuals.…”

Section: Resultsmentioning

confidence: 99%

“…The findings for this species in the beef liver are interesting, given that its epidemiology and route of transmission have not been well established (Costa et al . 2020). The zoonosis through the food chain (mainly products from cattle and sheep) has been assumed to be the most probable route of transmission (Wagenaar et al .…”

Section: Resultsmentioning

confidence: 99%

“…Nevertheless, other studies suggest person‐to‐person transmission through sexual contact or by mother to newborn, and from newborn to another newborn (Costa et al . 2020). Recently, Iraola et al .…”

Section: Resultsmentioning

confidence: 99%

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Campylobacter jejuni and other emerging Campylobacteraceae in retail beef liver – an underestimated potential source?

Lopez-Cantillo

Opazo-Capurro

López-Joven

et al. 2022

Letters in Applied Microbiology

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Bovine by‐products, such as liver, could be an underestimated source of Campylobacter jejuni. Therefore, our aims were to evaluate the occurrence of C. jejuni and other Campylobacteraceae in retail beef liver and characterize their antibiotic resistance (ciprofloxacin, tetracycline, erythromycin and gentamicin) and potential genetic relationship by flagellin gene restriction fragment length polymorphism (flaA‐RFLP) and multilocus sequence typing with clinical strains. Seventy‐six out of 206 samples (36·9%) were positive for Campylobacter and related organisms. Arcobacter butzleri was the most frequently isolated species (21·8%), followed by C. jejuni (9·7%), C. fetus (7·8%) and C. coli (1%). The C. jejuni strains showed resistance to tetracycline (17·2%) or ciprofloxacin (6·9%), with only one strain resistant to both antibiotics. Meanwhile, 8·3% of ciprofloxacin resistance was observed in C. fetus. The other species showed no resistance. Most of the clonal complexes (CC) in which the C. jejuni genotypes were grouped (CC‐21, 42, 48 and 52), coincided with genotypes of clinical strains previously reported in Chile. As such, this study provides evidence that beef liver could be an underestimated route for resistant C. jejuni to humans. Further studies should assess whether this food could play a role in the transmission of other emerging Campylobacteraceae such as those reported here.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Campylobacter jejuni and other emerging Campylobacteraceae in retail beef liver – an underestimated potential source?

Lopez-Cantillo

Opazo-Capurro

López-Joven

et al. 2022

Letters in Applied Microbiology

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“…3 The bacteriological analysis of healthy goats in this study revealed that goats could harbor a variety of zoonotic pathogens in their intestines during their growth, especially in the pre-weaning stage. These zoonotic bacteria mainly include the previous reported Lactococcus garvieae, 8 Helicobacter pylori, 8,9 Klebsiella pneumoniae, 10 Shigella sonnei, 11 Shigella boydii, 12 Campylobacter coli, 13 Salmonella enterica, 14 Acinetobacter baumannii, 15 Shigella flexneri, 12 Shigella dysenteriae, 12 Clostridium perfringens, 16 Campylobacter jejuni, 13 Campylobacter lanienae, 17 Salmonella bongori, 18 Campylobacter fetus, 19,20 Listeria monocytogenes, 21 Acinetobacter haemolyticus, 22 Mycobacterium tuberculosis, 23 Mycobacterium neglectum, 24 and Burkholderia pseudomallei. 25 The results suggest that goats may act as a reservoir for many zoonotic bacteria.…”

Section: Discussionmentioning

confidence: 99%

Zoonotic Bacteria Harboring in Goat Intestine: A One Health Perspective

Cheng¹,

Wang²,

Cheng³

et al. 2022

J. Pure Appl. Microbiol.

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The risk of zoonosis transmission when handling livestock or animal products is substantial, ‘One Health’ interventions should be an effective strategy for the control of many zoonotic bacteria. In this study, 26 fresh fecal samples from 2 clinically healthy goats were collected at different day ages to survey goat-borne zoonotic bacterial infection, and 19 fresh fecal samples from diarrhetic goats were tested to evaluate the possible role of zoonotic pathogens in goat diarrhea. Following all samples were analyzed by Metagenomic Sequencing, a total of 20 kinds of zoonotic bacteria were screened from healthy goats, and 11 (55%) of them were infection mainly during the preweaned period. Of the 19 fresh fecal samples from diarrhetic goats, all were confirmed to be zoonotic bacterial infection positive (range from 11 to 12 species). After comparison with healthy samples of the same or similar day-age goats, it was found that Lactococcus garvieae, Helicobacter pylori, Klebsiella pneumoniae, Shigella sonnei, Shigella boydii, Campylobacter coli, Salmonella enterica, Acinetobacter baumannii, Shigella flexneri, Shigella dysenteriae and Clostridium perfringens and Campylobacter fetus were highly increased incases in some diarrheic cases, while the remains had no significant change. The results suggest that goats may act as a reservoir for many zoonotic bacteria, and some of them may be associated with goat intestinal inflammation.

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“…We also show conservation among ST3 Cff strains, pointing to a stable lineage with CITCf01 and CITCf02 belonging to this ST. Limited source attribution of sporadic cases exists, but food animals are often suspected (Costa et al 2020), despite the infrequent isolation of Cff from food (Scanlon et al 2013;Wagenaar et al 2014), where the latter may be a consequence of insufficient detection systems. Undercooked meat was implicated as the likely cause of C. fetus bacteraemia and meningitis in a 33-year-old woman on maintenance therapy for acute lymphoblastic leukaemia, suggesting that neutropenic diet should be considered (Nakatani et al 2021).…”

Section: Discussionmentioning

confidence: 99%

Phenotypic and genetic analyses of two Campylobacter fetus isolates from a patient with relapsed prosthetic valve endocarditis

Lynch

Buttimer

Epping

et al. 2021

Pathogens and Disease

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Campylobacter fetus can cause intestinal and systemic disease in humans and are well established veterinary and economic pathogens. We report the complete genomic sequences of two C. fetus subsp. fetus (Cff) isolates recovered in 2017 (CITCf01) and 2018 (CITCf02) from a case of recurrent prosthetic valve endocarditis. Both were capable of growth aerobically. Their genomes were found to be highly conserved and syntenic with 99.97% average nucleotide identity (ANI) while differences in their respective sap loci defined the temporal separation of their genomes. Based on core genome phylogeny and ANI of 83 Cff genomes belonging to the previously described human-associated Cff lineage, CITCf01 and CITCf02 grouped in a clade of eleven sequence type (ST)3 Cff (including the Cff type strain NCTC 10842T). CITCf01 and CITCf02 were marked for their lack of unique genomic features when compared to isolates within the subspecies and the type strain in particular. We identified point mutations in oxidative stress response genes, among others, that may contribute to aerobiosis. We report a case of Cff causing relapsed prosthetic valve endocarditis and we highlight the sap island as a polymorphic site within the genetically stable ST3 lineage, central to pathogenicity.

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Polyclonal Campylobacter fetus Infections Among Unrelated Patients, Montevideo, Uruguay, 2013–2018

Cited by 4 publications

References 12 publications

Campylobacter jejuni and other emerging Campylobacteraceae in retail beef liver – an underestimated potential source?

Campylobacter jejuni and other emerging Campylobacteraceae in retail beef liver – an underestimated potential source?

Zoonotic Bacteria Harboring in Goat Intestine: A One Health Perspective

Phenotypic and genetic analyses of two Campylobacter fetus isolates from a patient with relapsed prosthetic valve endocarditis

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