Polychondritis Associated with Chronic Hepatitis C Virus Infection: Figure 1.

Alvi, S. Y.; Magrey, Marina

doi:10.3899/jrheum.101338

Cited by 1 publication

(1 citation statement)

References 12 publications

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“…[ 20 ] Chronic hepatitis C virus infection may nonspecifically activate the immune system and thus trigger RP. [ 21 , 22 ] The autoimmune pathogenesis is hypothetically induced by the aforementioned precipitating factors, which expose connective tissue or cell membrane self-epitopes in genetically susceptible individuals. Several autoantibodies have been found in RP, including collagen type II, [ 23 ] matrilin 1, [ 24 ] cochlea, vestibule, and corneal epithelium.…”

Section: Discussionmentioning

confidence: 99%

Case report of mixed-type autoimmune hemolytic anemia in a patient with relapsing polychondritis

Luo

Zuo

et al. 2018

Medicine

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Rationale:Relapsing polychondritis (RP) is a rare autoimmune-related disease and may be associated with other autoimmune diseases.Patient concerns: Here we reported a case of RP patients with mixed-type AIHA. The patient was diagnosed with RP in March 2008 which was treated and the patient was in stable condition. Laboratory data revealed progressive decrease in hemoglobin during her hospitalization due to pulmonary infection in 2016. Positive Coombs’ test and moderate titer of anti-cold agglutinin was detected.Diagnosis:Mixed-type AIHA was diagnosed as a comorbidity in this case given the circumstance that her RP was stable and low-dose oral corticosteroids was enough to maintain remission.Interventions:The patient was treated with intravenous immunoglobulin and steroids.Outcomes:The patient's body temperature dropped and hemoglobin levels rose in 2 weeks.Lessons:Reports of RP patients with autoimmune hemolytic anemia (AIHA) are extremely rare and cases with the mixed-type AIHA has not been reported. Here we describe a case of RP with mixed-type AIHA which was considered as a comorbidity rather than a complication.

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