Polychlorinated dibenzo-p-dioxins and related compounds: Correlations of levels in human tissues and in blood

Iida, Takao; Hirakawa, Hironori; Matsueda, Takahiko; Nagayama, Junya; Nagata, Takeaki

doi:10.1016/s0045-6535(98)00478-0

Cited by 42 publications

(22 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Blood PCDD/ Fs also show high correlation with those of body and milk lipids. Blood specimens are generally used for human risk assessment 24,25) . The mean and SD (standard deviation) of 17 PCDD/F isomer concentrations in workers and residents near the MSW incinerators.…”

Section: Exposure Assessment Of Pcdd/fs Homologue In Workers and Resimentioning

confidence: 99%

Health Survey on Workers and Residents Near the Municipal Waste and Industrial Waste Incinerators in Korea.

et al. 2003

View full text Add to dashboard Cite

Hazardous substances, such as polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) also have been detected in Municipal Solid Waste (MSW)and industrial waste incinerators in Korea. In this study, we estimated the exposure status of these hazardous substances and their heath effects in workers and residents near the MSW incinerators and residents near the industrial waste incinerators. We interviewed 13 workers and 16 residents from the area around the two MSW incinerators, and further 10 residents from the area around one industrial waste incinerator, which is suspected to emit higher hazardous substances. During the interview we collected information including sociodemographic information, personal habits, work history, detailed gynecologic and other medical history. Blood samples from 45 subjects were also collected for analysis of PCDDs and PCDFs, which were analyzed by HRGC-HRMS (High Resolution Gas Chromatography -High Resolution Mass Spectrometer). In addition to a questionnaire survey, urinary concentrations of 8-hydroxydeoxyguanosine (8-OH-dG) and malondialdehyde (MDA) were measured as oxidative injury biomarkers. Urinary concentrations of 8-OH-dG were determined by in vitro ELISA (JAICA, Fukuroi, Japan). MDA were determined by HPLC using adduct with TBA (thiobarbituric acid). The PCDD/F concentrations in residents from the area around industrial waste incinerator were higher than those in workers and residents from the area around MSW incinerator. The average toxic equivalency (TEQ) concentrations of PCDD/Fs in residents from the area around industrial waste incinerator were 53.4 pg I-TEQs/g lipid. The average TEQ concentrations of PCDD/Fs in workers and residents near MSW incinerator were 12.2 pg I-TEQs/g lipid. Estimated daily intake (EDI) of each person was calculated, and the EDI of all workers and residents near MSW incinerator were within the tolerable daily intake range. But for only 30% of 10 people near the industrial waste incinerator were the EDI within the tolerable daily intake range (1-4 pg I-TEQ/kg bw/day) suggested by WHO (1997). The oxidative stress of residents near the industrial waste incinerator was higher than that in workers and residents from the area around MSW incinerator. This oxidative stress may have been caused by hazardous substances, such as PCDD/Fs emitted by incinerators. The residents from the area around industrial waste incinerator were exposed to hazardous substances such as PCDD/ Fs. Proper protection strategies against these hazardous chemicals are needed.

show abstract

Section: Exposure Assessment Of Pcdd/fs Homologue In Workers and Resimentioning

confidence: 99%

Health Survey on Workers and Residents Near the Municipal Waste and Industrial Waste Incinerators in Korea.

et al. 2003

View full text Add to dashboard Cite

show abstract

“…The bile and blood levels were one-third of that in the liver in terms of TEQ per g lipid. Iida et al (1999) also reported a similar trend in the ratio between blood and liver, although the ratio of liver to blood was 4.6 in their cases. It is noteworthy that the dioxin burden in liver is 38 times higher than that in blood in terms of per organ weight.…”

Section: Discussionmentioning

confidence: 59%

“…Further, we can deduce liver dioxin levels, by the equation of y = 1.74x 52.9 with a correlation coefficient of 0.73, with x = total-TEQ value of blood. Iida et al (1999) also demonstrated the presence of a good correlation between the blood and liver in levels of several congeners of PCDDs, PCDFs and Co-PCBs, although they did not conduct studies on total-TEQ.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Dioxins in bile in relation to those in the human liver and blood.

et al. 2001

View full text Add to dashboard Cite

The levels of 20 dioxin congeners, 7 polychlorinated dibenzo-p-dioxins (PCDDs), 10 polychlorinated dibenzofurans (PCDFs) and three coplanar polychlorinated biphenyls (Co-PCBs), in bile were examined in comparison with those in the blood and liver, in 27 autopsy cases. Total-TEQ values were the same in the bile (43.2 30.9 pg TEQ /g lipid) and blood (43.1 24.2 pg TEQ/g lipid ), and three times higher in the liver (127.8 57.4 pg TEQ/g lipid). Highly chlorinated PCDDs and PCDFs have a tendency to accumulate in the liver, and their levels in bile and blood were relatively low compared with those in the liver, with 1,2,3,4,6,7,8-heptachlorodibenzofuran having the highest tendency among the 20 congeners. Daily excretion in bile was calculated to be 54 pg TEQ at age 65, by assuming that daily bile secretion is 750 ml and is concentrated 7.5-fold in the gallbladder. The correlation between bile and blood total-TEQ was high, with a correlation coefficient of 0.89 among the 27 autopsy cases. Thus, the regression equation of y = 1.14x -6.02 will provide us levels in bile (total TEQ per g lipid), knowing the blood total-TEQ level, where x is total-TEQ per g lipid of the blood. Furthermore, accumulation of dioxins was estimated to be 0.99, 0.70 and 1.91 pg TEQ /g lipid /year in bile, blood and liver, respectively.

show abstract

“…We have previously reported a significant correlation between the dioxin concentrations in blood and that in tissues (subcutaneous adipose tissue, mesentery fat, liver, kidney, muscles, brain, spleen), and have noted that the dioxin concentrations in blood lipids have almost the same level as the concentrations in fat tissues 2,3) . Dioxins in the blood of municipal incinerator plant laborers and people who live near factories have been investigated in Japan for several years 4,5) .…”

Section: Introductionmentioning

confidence: 92%

Measurement of Dioxins in Human Blood: Improvement of Analytical Method.

Iida

Todaka²

2003

INDUSTRIAL HEALTH

Self Cite

View full text Add to dashboard Cite

Abstract:We have improved the method of measuring dioxins in the blood of Yusho patients; with this improved method, it is possible to take measurements quickly and precisely, using as little as 5g of blood. The specific points of improvement of this method are the extraction of lipids from blood by accelerated solvent extractor (ASE), the miniaturization of column cleanup for the purification of dioxins, and the use of a solvent cut large volume (SCLV) injection system with high-resolution gas chromatography/high-resolution mass spectrometry (HRGC/HRMS). Using this improved method of analysis, we are currently investigating dioxins in the blood of 400 Yusho patients collected in Japan in 2002. We here describe the details of our announcement at Dioxin 2002 Symposium about the improvement of this analysis method, and discuss several other modifications 1) .

show abstract

Polychlorinated dibenzo-p-dioxins and related compounds: Correlations of levels in human tissues and in blood

Cited by 42 publications

References 5 publications

Health Survey on Workers and Residents Near the Municipal Waste and Industrial Waste Incinerators in Korea.

Health Survey on Workers and Residents Near the Municipal Waste and Industrial Waste Incinerators in Korea.

Dioxins in bile in relation to those in the human liver and blood.

Measurement of Dioxins in Human Blood: Improvement of Analytical Method.

Contact Info

Product

Resources

About