Polychlorinated biphenyls suppress thyroid hormone-induced transactivation

Iwasaki, Tadaaki; Miyazaki, Wataru; Takeshita, Akira; Kuroda, Yoichiro; Koibuchi, Noriyuki

doi:10.1016/s0006-291x(02)02659-1

Cited by 133 publications

(104 citation statements)

References 26 publications

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“…1B). Although the suppression by 10 -10 -10 -5 M PCB were significant comparing to the absence of PCB, the magnitude of suppression between 10 -10 M and 10 -5 M PCB treatment was not statistically significant, indicating that PCB may not competitively inhibit TH binding to TR 8) . Then we found that PCB may partially dissociate TR from TRE 9) using electrophoretic mobility shift assay (EMSA), by acting to DNA-binding domain of TR 10) .…”

mentioning

confidence: 76%

“…scription at doses as low as 10 -10 M on artificial THresponse elements (TRE) such as direct repeat (DR)-4, F2, and palindromic (pal) TRE 8,9) (Fig. 1B).…”

mentioning

confidence: 99%

“…We particularly focused on hydroxylated metabolites, because we have previously shown that some OH-PCBs such as 4'-OH-2',3,3',4',5'-pentachloro biphenyl (4'-OH-PCB106) greatly suppressed TR-mediated transcription [8][9][10] .…”

mentioning

confidence: 99%

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The Effect of Hydroxylated Polychlorinated Biphenyl (OH-PCB) on Thyroid Hormone Receptor (TR)-mediated Transcription through Native-Thyroid Hormone Response Element (TRE)

et al. 2010

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mentioning

confidence: 76%

“…scription at doses as low as 10 -10 M on artificial THresponse elements (TRE) such as direct repeat (DR)-4, F2, and palindromic (pal) TRE 8,9) (Fig. 1B).…”

mentioning

confidence: 99%

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The Effect of Hydroxylated Polychlorinated Biphenyl (OH-PCB) on Thyroid Hormone Receptor (TR)-mediated Transcription through Native-Thyroid Hormone Response Element (TRE)

et al. 2010

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“…by enhancing the recruitment of transcriptional corepressors and/or the dissociation of coactivators [71]. Moreover, Iwasaki et al [72] showed that 4-OH-PCB was able to suppress TR/coactivator (SRC-1) complex-mediated transactivation, and that this mechanism could explain the suppression of TR-mediated transcription in the presence of OH-PCB in simian kidney cells.…”

Section: Disruption At Other Levels Of the Transcriptional Processmentioning

confidence: 99%

Endocrine disruptors and thyroid hormone physiology

Jugan

Lévi

Blondeau

2010

Biochemical Pharmacology

210

115

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Endocrine disruptors are man-made chemicals that can disrupt the synthesis, circulating levels, and peripheral action of hormones. The disruption of sex hormones was subject of intensive research, but thyroid hormone synthesis and signaling are now also recognized as important targets of endocrine disruptors. The neurological development of mammals is largely dependent on normal thyroid hormone homeostasis, and it is likely to be particularly sensitive to disruption of the thyroid axis. Here, we survey the main thyroid-disrupting chemicals, such as polychlorinated biphenyls, perchlorates, and brominated flame retardants, that are characteristic disruptors of thyroid hormone homeostasis, and look at their suspected relationships to impaired development of the human central nervous system. The review then focuses on disrupting mechanisms known to be directly or indirectly related to the transcriptional activity of the thyroid hormone receptors.

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“…There are some hydroxylated PCBs with higher affinity for transthyretin and TBG compared to T4 106) . Iwasaki et al (2002) showed by a reporter assay that the hydroxylated PCBs affected the TR (thyroid hormone receptor) /coactivator complex to inhibit T3-TR transactivation 107) . In contrast, Morse et al (1996) suggested that the T3 level in the brain remained constant because the induction of brain type II thyroxine 5'-deiodinase activity compensates for decreases in brain T4 levels 108) .…”

Section: Disruption Of Thyroxin Function By Pcb Exposurementioning

confidence: 99%

Developmental Neurotoxicity of Dioxin and Its Related Compounds.

Kakeyama

Tohyama

2003

INDUSTRIAL HEALTH

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This manuscript reviewed the neurotoxicity of dioxins and related compounds with an emphasis on maternal exposure. The brain during developmental period is thought to be highly sensitive to dioxin and its related compounds that affect a broad range of brain functions from the advanced brain function to the reproduction-controlling function, even at low doses. It is suggested that dioxins exhibit endocrine-disrupting action on the gonadal and thyroid hormone axes, as well as the 'neural-disrupting action' on neural transmission and neural network formation. From behavioral toxicological studies as well as studies on the underlying mechanisms of dioxins' toxicity, dioxins affect some specific functions in particular regions or cells of the brain at critical windows during the developmental period.

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Polychlorinated biphenyls suppress thyroid hormone-induced transactivation

Cited by 133 publications

References 26 publications

The Effect of Hydroxylated Polychlorinated Biphenyl (OH-PCB) on Thyroid Hormone Receptor (TR)-mediated Transcription through Native-Thyroid Hormone Response Element (TRE)

The Effect of Hydroxylated Polychlorinated Biphenyl (OH-PCB) on Thyroid Hormone Receptor (TR)-mediated Transcription through Native-Thyroid Hormone Response Element (TRE)

Endocrine disruptors and thyroid hormone physiology

Developmental Neurotoxicity of Dioxin and Its Related Compounds.

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