Polychlorinated biphenyl exposure and deiodinase activity in young infants

Soechitram, Shalini D.; Berghuis, Sietske A.; Visser, Theo J.; Sauer, Pieter

doi:10.1016/j.scitotenv.2016.09.098

Cited by 34 publications

(30 citation statements)

References 39 publications

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“…While no correlation was found between PCBs, T4, TSH and TBG values in the cord blood, there was a positive correlation between the two congeners of the PCBs and the sum of ten PCBs dosed and the T3/rT3 ratio in the cord blood. One of the hydroxylated congeners was also correlated with serum T4 at 3 months of age and with T4, T4S and T3 at eighteen months of age [10]. These findings suggest an effect of PCBs on thyroid hormone metabolism rather than synthesis and secretion.…”

Section: Industrial Chemicalsmentioning

confidence: 68%

“…The hypothesis behind this action was that PCBs alter thyroid status impacting on deiodinase function [10].…”

Section: Industrial Chemicalsmentioning

confidence: 99%

“…[10] Evaluated the associations between maternal blood levels of 3 PCBs congeners and thyroid hormones in maternal and umbilical-cord blood in pregnant women in the first trimester of pregnancy. Thyroid hormone levels also assessed at delivery and in cord blood in 260subjects.…”

Section: Industrial Chemicalsmentioning

confidence: 99%

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Thyroid Disrupting Chemicals

Calsolaro

Pasqualetti

Niccolai

et al. 2017

Preprint

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Endocrine disruptor compounds are exogenous agents able to interfere with a gland function, exerting their action across different functional passages, from the synthesis to the metabolism and binding to receptors of the hormone produced. Several issues such as different levels and time of exposure and different action across different ages as well as gender, make the study of endocrine disruptors still a challenge. Thyroid is very sensitive to the action of disruptors, and considering the importance of a correct thyroid function for physical and cognitive functioning, addressing this topic should be considered a priority. In this review we examined the most recent studies, many of them concentrating on maternal and child exposure, conducted to assess the impact of industrial chemicals which showed an impact on thyroid function. So far, the number of studies conducted on that topic is not sufficient to provide solid conclusions and lead to homogeneous guidelines. The lack of uniformity is certainly due to differences in areas and populations examined, the different conditions of exposures and the remarkable inter-subject variability. Nonetheless, the European Commission for Health and Food Safety is implementing recommendations to ensure that substances identified as endocrine disruptors will be withdrawn from the market.

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Section: Industrial Chemicalsmentioning

confidence: 68%

“…The hypothesis behind this action was that PCBs alter thyroid status impacting on deiodinase function [10].…”

Section: Industrial Chemicalsmentioning

confidence: 99%

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Thyroid Disrupting Chemicals

Calsolaro

Pasqualetti

Niccolai

et al. 2017

Preprint

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“…Primary hypothyroidism may also result from exposure to polyhalogenated aromatic hydrocarbons (383) and bisphenol A (384). The effects of polychlorinated biphenyls (PCBs) include increased hepatic degradation of thyroid hormones and inhibition of deiodinase activity, which applies predominantly to cerebral D3 (385–387). Typical high-T3 syndromes under PCB exposure are therefore probably caused by decreased D3 activity rather than by stimulated D1 or D2 activity.…”

Section: Effects Of Heterogeneous or Unknown Originmentioning

confidence: 99%

Thyroid Allostasis–Adaptive Responses of Thyrotropic Feedback Control to Conditions of Strain, Stress, and Developmental Programming

Hoermann²,

et al. 2017

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The hypothalamus–pituitary–thyroid feedback control is a dynamic, adaptive system. In situations of illness and deprivation of energy representing type 1 allostasis, the stress response operates to alter both its set point and peripheral transfer parameters. In contrast, type 2 allostatic load, typically effective in psychosocial stress, pregnancy, metabolic syndrome, and adaptation to cold, produces a nearly opposite phenotype of predictive plasticity. The non-thyroidal illness syndrome (NTIS) or thyroid allostasis in critical illness, tumors, uremia, and starvation (TACITUS), commonly observed in hospitalized patients, displays a historically well-studied pattern of allostatic thyroid response. This is characterized by decreased total and free thyroid hormone concentrations and varying levels of thyroid-stimulating hormone (TSH) ranging from decreased (in severe cases) to normal or even elevated (mainly in the recovery phase) TSH concentrations. An acute versus chronic stage (wasting syndrome) of TACITUS can be discerned. The two types differ in molecular mechanisms and prognosis. The acute adaptation of thyroid hormone metabolism to critical illness may prove beneficial to the organism, whereas the far more complex molecular alterations associated with chronic illness frequently lead to allostatic overload. The latter is associated with poor outcome, independently of the underlying disease. Adaptive responses of thyroid homeostasis extend to alterations in thyroid hormone concentrations during fetal life, periods of weight gain or loss, thermoregulation, physical exercise, and psychiatric diseases. The various forms of thyroid allostasis pose serious problems in differential diagnosis of thyroid disease. This review article provides an overview of physiological mechanisms as well as major diagnostic and therapeutic implications of thyroid allostasis under a variety of developmental and straining conditions.

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“…Disruption of TH homeostasis leads to side effects including hypothyroidism, cardiovascular disease, and structural abnormalities . Dio proteins play an important role in early developmental stages and a recent study suggests that PCBs may inhibit their activity in infants . PCBs, dioxins and other organochlorine compounds have also been shown to inhibit Dio in various organisms, such as rats, fish, birds, chickens, and eels .…”

Section: Introductionmentioning

confidence: 99%

Halogen Bonding Interactions of Polychlorinated Biphenyls and the Potential for Thyroid Disruption

Marsan

Bayse

2020

Chemistry A European J

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Polychlorinated biphenyl (PCB) flame retardants are persistent pollutants and inhibit neurodevelopment, particularly in the early stages of life. Halogen bonding (XB) to the iodothyronine deiodinases (Dio) that modulate thyroid hormones (THs) is a potential mechanism for endocrine disruption. Cl⋅⋅⋅Se XB interactions of PCBs with SeMe−, a small model of the Dio active site selenocysteine, are compared with previous results on polybrominated diphenylethers (PBDEs) and THs using density functional theory. PCBs generally display weaker XB interactions compared to PBDEs and THs, consistent with the dependence of XB strength on the size of the halogen (I>Br>Cl). PCBs also do not meet a proposed energy threshold for substrates to undergo dehalogenation, suggesting they may behave as competitive inhibitors of Dio in addition to other mechanisms of endocrine disruption. XB interactions in PCBs are position‐dependent, with ortho interactions slightly more favorable than meta and para interactions, suggesting that PCBs may have a greater effect on certain classes of Dio. Flexibility of PCBs around the biphenyl C−C bond is limited by ortho substitutions relative to the biphenyl linkage, which may contribute to the ability to inhibit Dio and other TH‐related proteins.

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Polychlorinated biphenyl exposure and deiodinase activity in young infants

Cited by 34 publications

References 39 publications

Thyroid Disrupting Chemicals

Thyroid Disrupting Chemicals

Thyroid Allostasis–Adaptive Responses of Thyrotropic Feedback Control to Conditions of Strain, Stress, and Developmental Programming

Halogen Bonding Interactions of Polychlorinated Biphenyls and the Potential for Thyroid Disruption

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