Polychlorinated Biphenyl and Organochlorine Pesticide Levels in Human Breast Milk from the Mediterranean city Antalya, Turkey

Çok, İsmet; Yelken, Çiğdem; Durmaz, Emre; Üner, Mine; Sever, Barış; Satır, Funda

doi:10.1007/s00128-011-0221-3

Cited by 32 publications

(6 citation statements)

References 23 publications

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“…α-HCH and γ-HCH were detected only 22.7 and 12.0 % of samples. Previously, similar profiles of HCH isomers have been reported in human samples (Covaci & Schepens 2001;Çok et al 2011). Aldrin was found in 58.7 % of milk samples and the diedrin was not detected in Ankara in the present study.…”

Section: The Levels Of Milk Ocpssupporting

confidence: 56%

“…Email: siyalcin@hacettepe.edu.tr restricted or banned the use of persistent OCPs. Despite the global declining trends of OCPs in recent years, OCPs were still observed in human breast milk from developing countries due to their persistence in the environment and bioaccumulation along the food chains (UNEP 2009;Çok et al 2011;Govarts et al 2012;Mikeš et al 2012). Therefore, further monitoring is necessary.…”

Section: Introductionmentioning

confidence: 98%

“…The levels of OCPs in breast milk have been used to assess the trend of pollution by OCPs in the environment since the early 1970s and to evaluate the success of the ban of OCPs in numerous countries (Damgaard et al 2006;Colles et al 2008;UNEP 2009;Mikeš et al 2012). OCP residues in human milk have also been monitored in the Turkish population by carrying out regional surveys at irregular time intervals since 1983 (Çok et al 2011;Çok et al 2012;Kaynak Türkmen et al 2013).…”

Section: Introductionmentioning

confidence: 98%

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Organochlorine pesticide residues in breast milk and maternal psychopathologies and infant growth from suburban area of Ankara, Turkey

Yalçın¹,

Örün²,

Aykut³

2014

International Journal of Environmental Health Research

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We aimed to determine the levels of organochlorine pesticides (OCPs) in the breast milk; to assess the effect of detectable OCPs on maternal-infant characteristics and; to evaluate the relation between OCPs and the maternal psychopathologies [Brief Symptom Inventory (BSI), Postpartum Bonding Questionnaire (PBQ), Mother-to-Infant Bonding Scale (MIBS) and Edinburgh Postnatal Depression Scale (EPDS)] and infant growth. DDT, beta-hexachlorocyclohexane (HCH), aldrin and heptachlor were detected in 89.3, 70.7, 58.7 and 34.7 % of the samples, respectively. Mothers with low monthly family income had detectable DDTs less frequently. The frequencies of detectable heptachlor epoxide were significantly higher in mothers with gestational nausea. Anaemic mothers had more frequently detectable alpha-HCH. Z scores of head circumference were inversely correlated with beta-HCH and DDT levels. The heptachlor epoxide levels were positively correlated with PBQ, MIBS and indexes of BSI. No relation was detected between EPDS and OCPs. Further studies are needed for changes in maternal psychopathologies.

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Section: The Levels Of Milk Ocpssupporting

confidence: 56%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 98%

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Organochlorine pesticide residues in breast milk and maternal psychopathologies and infant growth from suburban area of Ankara, Turkey

Yalçın¹,

Örün²,

Aykut³

2014

International Journal of Environmental Health Research

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“…The sum concentrations from India and Turkey are exceptionally high, i.e., concentrations above 1000 ng/g fat (Cok et al 2011; Sanghi et al 2003). These high levels are comparable to some data on DDT in mothers’ milk (cf.…”

Section: Resultsmentioning

confidence: 99%

Spatial and temporal trends of the Stockholm Convention POPs in mothers’ milk — a global review

Fång

Nyberg

Winnberg

et al. 2015

Environ Sci Pollut Res

105

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Persistent organic pollutants (POPs) have been of environmental and health concern for more than half a century and have their own intergovernmental regulation through the Stockholm Convention, from 2001. One major concern is the nursing child’s exposure to POPs, a concern that has led to a very large number of scientific studies on POPs in mothers’ milk. The present review is a report on the assessment on worldwide spatial distributions of POPs and of their temporal trends. The data presented herein is a compilation based on scientific publications between 1995 and 2011. It is evident that the concentrations in mothers’ milk depend on the use of pesticides and industrial chemicals defined as POPs. Polychlorinated biphenyls (PCBs) and “dioxins” are higher in the more industrialized areas, Europe and Northern America, whereas pesticides are higher in Africa and Asia and polybrominated diphenyl ethers (PBDEs) are reported in higher concentrations in the USA. POPs are consequently distributed to women in all parts of the world and are thus delivered to the nursing child. The review points out several major problems in the reporting of data, which are crucial to enable high quality comparisons. Even though the data set is large, the comparability is hampered by differences in reporting. In conclusion, much more detailed instructions are needed for reporting POPs in mothers’ milk. Temporal trend data for POPs in mothers’ milk is scarce and is of interest when studying longer time series. The only two countries with long temporal trend studies are Japan and Sweden. In most cases, the trends show decreasing concentrations of POPs in mothers’ milk. However, hexabromocyclododecane is showing increasing temporal concentration trends in both Japan and Sweden.

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“…1–3 2,2’, 4,4’, 5,5’-hexachlorobiphenyl (PCB-153) is one of the most abundant congeners in the environment, in the food web, and in both animals and humans. 4–11 In humans, PCB-153 was found at levels of 121 ng/g fat of mammary gland, 12 21.6 ng/g hair, 6 9.5 ng/g muscle, 7.5 ng/g liver, 3.1 ng/g brain, and 2.6 ng/g kidney. 4 Exposure of humans to this pollutant is unavoidable via air and food.…”

Section: Introductionmentioning

confidence: 99%

Role of Oil Vehicle on Hepatic Cell Proliferation in PCB-Treated Rats

Bunaciu

Tharappel

Lehmler

et al. 2011

J Environ Pathol Toxicol Oncol

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Here we report the role of dietary glycine and the type of oil used as a vehicle on hepatotoxicity in 2,2’,4,4’,5,5’-hexachlorobiphenyl (PCB-153)-treated or control rats. In the first study, glycine or valine (as control) was fed in an unrefined diet at 5% for the entire study (5 days) to inhibit Kupffer cell activity. PCB-153 (100 or 300 µmol/kg) dissolved in medium chain triglyceride (MCT) oil, was injected i.p. two days before euthanasia; the peroxisome proliferator Wy-14,643 was included as a positive control. MCT oil decreased cell proliferation by about 50%. PCB-153 slightly increased hepatic cell proliferation, but dietary glycine did not reduce cell proliferation. Because of the inhibition of cell proliferation in rats receiving MCT oil compared to rats receiving no injection, we hypothesized that MCT oil may have been inhibiting the hepatocyte proliferation in PCB-153-treated rats. We therefore performed another experiment using three types of oil as a vehicle for PCB-153: MCT oil, corn oil and olive oil. Rats were injected with PCB-153 (300 µmol/kg) or one of the vehicles, again two days before euthanasia. MCT oil again decreased the hepatocyte proliferation by about 50%. In rats receiving PCB-153, hepatocyte proliferation was slightly higher than their respective vehicle controls for corn oil and olive oil but not for MCT oil. These studies show that the oil vehicle is important in cell proliferation after PCB exposure, with MCT oil appearing to be protective.

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Polychlorinated Biphenyl and Organochlorine Pesticide Levels in Human Breast Milk from the Mediterranean city Antalya, Turkey

Cited by 32 publications

References 23 publications

Organochlorine pesticide residues in breast milk and maternal psychopathologies and infant growth from suburban area of Ankara, Turkey

Organochlorine pesticide residues in breast milk and maternal psychopathologies and infant growth from suburban area of Ankara, Turkey

Spatial and temporal trends of the Stockholm Convention POPs in mothers’ milk — a global review

Role of Oil Vehicle on Hepatic Cell Proliferation in PCB-Treated Rats

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