Polycationic condensed tannin/polysaccharide-based polyelectrolyte multilayers prevent microbial adhesion and proliferation

Facchi, Suelen Pietrobon; Oliveira, Ariel C. de; Bezerra, Ewerton O.T.; Vlcek, Jessi; Hedayati, Mohammadhasan; Reynolds, Melissa M.; Kipper, Matt J.; Martins, Alessandro F.

doi:10.1016/j.eurpolymj.2020.109677

Cited by 35 publications

(19 citation statements)

References 51 publications

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“…Moreover, CTs from different plant sources were reported to exhibit antimicrobial activities, such as the inhibitory effect of rice straw CTs on Staphylococcus aureus , through the reduction of intercellular ATP and inhibition of bacterial biofilm formation [ 26 ]. Likewise, CT derivatives assembled with polysaccharides exhibited an antiadhesive and bactericidal effect on Pseudomonas aeruginosa and Staphylococcus aureus , which suggested their use to avoid infections imparted by bacterial adhesion to biomedical appliances [ 27 ]. Finally, CTs from Leucaena leucocephala showed apoptotic activity against human breast adenocarcinoma (MCF-7), human colon carcinoma (HT29), human cervical carcinoma (HeLa) and human liver carcinoma (HepG2) cell lines in vitro through cell shrinkage and nuclear condensation [ 28 ].…”

Section: Chemistry and Diversity Of Tanninsmentioning

confidence: 99%

Effect of Gut Microbiota Biotransformation on Dietary Tannins and Human Health Implications

et al. 2021

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Tannins represent a heterogeneous group of high-molecular-weight polyphenols that are ubiquitous among plant families, especially in cereals, as well as in many fruits and vegetables. Hydrolysable and condensed tannins, in addition to phlorotannins from marine algae, are the main classes of these bioactive compounds. Despite their low bioavailability, tannins have many beneficial pharmacological effects, such as anti-inflammatory, antioxidant, antidiabetic, anticancer, and cardioprotective effects. Microbiota-mediated hydrolysis of tannins produces highly bioaccessible metabolites, which have been extensively studied and account for most of the health effects attributed to tannins. This review article summarises the effect of the human microbiota on the metabolism of different tannin groups and the expected health benefits that may be induced by such mutual interactions. Microbial metabolism of tannins yields highly bioaccessible microbial metabolites that account for most of the systemic effects of tannins. This article also uses explainable artificial intelligence to define the molecular signatures of gut-biotransformed tannin metabolites that are correlated with chemical and biological activity. An understanding of microbiota–tannin interactions, tannin metabolism-related phenotypes (metabotypes) and chemical tannin-metabolites motifs is of great importance for harnessing the biological effects of tannins for drug discovery and other health benefits.

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Section: Chemistry and Diversity Of Tanninsmentioning

confidence: 99%

Effect of Gut Microbiota Biotransformation on Dietary Tannins and Human Health Implications

et al. 2021

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“…In this way, films and coatings with hydrophobic surfaces should interact better with the microbial cells, favoring adhesion. Hydrophilic surfaces should prevent the attachment of E. coli cells [ 13 , 14 , 49 , 50 ].…”

Section: Resultsmentioning

confidence: 99%

Bactericidal Pectin/Chitosan/Glycerol Films for Food Pack Coatings: A Critical Viewpoint

Machado

Facchi

Oliveira

et al. 2020

IJMS

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Pectin and chitosan films containing glycerol (Gly) at 5, 10, 15, 20, 30, and 40 wt % were prepared in an aqueous HCl solution (0.10 M) by the solvent evaporation method. The unwashed film (UF) containing 40 wt % Gly (UF40) had elongation at break (ε, %) of 19%. Washed films (WFs) had high tensile strength (σ > 46 MPa) and low elongation at break (ε, <5.0%), enabling their use in food packaging applications. The polymers’ self-assembling occurred during the washing, increasing the stiffness. The XPS analysis suggests that some HCl is lost during the drying process, resulting in a low acid content on the UF surfaces. The UF40 (at 5.0 mg/mL) exhibits cytocompatibility toward mammalian cells and antimicrobial and anti-adhesive properties against Escherichia coli. The remaining HCl in the UF40 can be a disadvantage for food packaging applications; the UF40 (∅ = 8.5 mm; 55 μm thickness) releases H3O+/HCl, reducing the pH to approximately 3.0 when kept in 200 mL distilled water for approximately 30 min. Therefore, we propose the use of UF40 to coat commercial food packaging. The UF40 has low permeability to water vapor and oxygen and works as a barrier against ultraviolet light. The UF40 is also colorless and completely transparent. The UF40 maintained tomatoes’ structural integrity for 18 days at room temperature with no oxidation or microorganism contamination. This paper presents a critical viewpoint concerning chitosan-based films with antimicrobial activities.

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“…Facchi et al assembled a polyphenolic tannin derivative (Tanfloc) with pectin and iota -carrageenan at pH 5.0 on oxidized glass. The PEMs significantly prevented the attachment and proliferation of S. aureus and P. aeruginosa after 24 h of exposure [ 239 ]. Compared to chitosan/heparin PEMs (10 layers), the Tanfloc/heparin PEMs (10 layers) deposited on oxidized glass support hemocompatible surfaces.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

“…The authors suggested that polyphenolic moieties on Tanfloc support a pseudo-zwitterionic effect and catechol moieties may both provide anti-platelet adhesion feature [ 154 ]. Therefore, amino-functionalized tannin derivative and the anti-adhesive and anticoagulant heparin activities impart the antimicrobial [ 239 ] and hemocompatible properties to the Tanfloc/heparin PEMs [ 154 ]. Hemocompatible PEMs can be deposited on biomedical devices (catheters, stents, and others) to prevent blood clotting in biomedical implants.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Polysaccharide-Based Materials Created by Physical Processes: From Preparation to Biomedical Applications

et al. 2021

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Polysaccharide-based materials created by physical processes have received considerable attention for biomedical applications. These structures are often made by associating charged polyelectrolytes in aqueous solutions, avoiding toxic chemistries (crosslinking agents). We review the principal polysaccharides (glycosaminoglycans, marine polysaccharides, and derivatives) containing ionizable groups in their structures and cellulose (neutral polysaccharide). Physical materials with high stability in aqueous media can be developed depending on the selected strategy. We review strategies, including coacervation, ionotropic gelation, electrospinning, layer-by-layer coating, gelation of polymer blends, solvent evaporation, and freezing–thawing methods, that create polysaccharide-based assemblies via in situ (one-step) methods for biomedical applications. We focus on materials used for growth factor (GFs) delivery, scaffolds, antimicrobial coatings, and wound dressings.

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Polycationic condensed tannin/polysaccharide-based polyelectrolyte multilayers prevent microbial adhesion and proliferation

Cited by 35 publications

References 51 publications

Effect of Gut Microbiota Biotransformation on Dietary Tannins and Human Health Implications

Effect of Gut Microbiota Biotransformation on Dietary Tannins and Human Health Implications

Bactericidal Pectin/Chitosan/Glycerol Films for Food Pack Coatings: A Critical Viewpoint

Polysaccharide-Based Materials Created by Physical Processes: From Preparation to Biomedical Applications

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