Polycarnitine: A New Biomaterial

Kamm, Birgit; Kamm, M.; Kiener, Andreas; Meyer, Hans‐Peter

doi:10.1002/chin.200608273

Cited by 2 publications

(2 citation statements)

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“…The results correspond well with the outcomes of other studies carried out at similar conditions with other Lactobacillus strains (83). After changing to a continuous fermentation mode with cell retention and control of glucose concentration, the best results were obtained by feeding of alfalfa press juice instead of synthetic nutrients (84). Together with high biomass concentrations and the number of living cells, the productivity increased considerably compared to fermentations performed using well adapted synthetic nutrients ( Table 3).…”

Section: Grasssupporting

confidence: 82%

Agricultural Residues as Feedstocks for Lactic Acid Fermentation

Pleißner

Venus

2014

ACS Symposium Series

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Section: Grasssupporting

confidence: 82%

Agricultural Residues as Feedstocks for Lactic Acid Fermentation

Pleißner

Venus

2014

ACS Symposium Series

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“…It is essential for the intramitochondrial transport of long‐chain fatty acids for β‐oxidation, regulation of CoA concentration and removal of the produced acyl groups, and is involved in both the metabolism of ketones for energy and the conversion of branched‐chain amino acids into energy (3,4). AcylCoA acts as a restraining factor for several enzymes participating in intermediary metabolism, and transformation of AcylCoA into acylcarnitine is an important system for removing toxic acyl groups from the body (5–7).…”

Section: Introductionmentioning

confidence: 99%

L‐Carnitine–L‐tartrate promotes human hair growth in vitro

Foitzik

Hoting

Förster

et al. 2007

Experimental Dermatology

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The trimethylated amino acid l-carnitine plays a key role in the intramitochondrial transport of fatty acids for beta-oxidation and thus serves important functions in energy metabolism. Here, we have tested the hypothesis that l-carnitine, a frequently employed dietary supplement, may also stimulate hair growth by increasing energy supply to the massively proliferating and energy-consuming anagen hair matrix. Hair follicles (HFs) in the anagen VI stage of the hair cycle were cultured in the presence of 0.5-50 microm of l-carnitine-l-tartrate (CT) for 9 days. At day 9, HFs treated with 5 microm or 0.5 microm of CT showed a moderate, but significant stimulation of hair shaft elongation compared with vehicle-treated controls (P < 0.05). Also, CT prolonged the duration of anagen VI, down regulated apoptosis (as measured by TUNEL assay) and up regulated proliferation (as measured by Ki67 immunohistology) of hair matrix keratinocytes (P < 0.5). By immunohistology, intrafollicular immunoreactivity for TGFbeta2, a key catagen-promoting growth factor, in the dermal papilla and TGF-beta II receptor protein in the outer root sheath and dermal papilla was down regulated. As shown by caspase activity assay, caspase 3 and 7, which are known to initiate apoptosis, are down regulated at day 2 and day 4 after treatment of HFs with CT compared with vehicle-treated control indicating that CT has an immediate protective effect on HFs to undergo programmed cell death. Our findings suggest that l-carnitine stimulates human scalp hair growth by up regulation of proliferation and down regulation of apoptosis in follicular keratinocytes in vitro. They further encourage one to explore topical and nutraceutical administration of l-carnitine as a well-tolerated, relatively safe adjuvant treatment in the management of androgenetic alopecia and other forms of hair loss.

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Polycarnitine: A New Biomaterial

Abstract: ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access the actual ChemInform Abstract, please click on HTML or PDF.

Cited by 2 publications

References 1 publication

Agricultural Residues as Feedstocks for Lactic Acid Fermentation

Agricultural Residues as Feedstocks for Lactic Acid Fermentation

L‐Carnitine–L‐tartrate promotes human hair growth in vitro

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