Polycarbonyl heterocyclics. [V]. Synthesis of pyrrolo[3,4‐c]pyridine and Furo[3,4‐c]‐pyridine derivatives by the Ring Transformation of Thiazolidine‐4‐on Derivatives

Abstract

2‐(Aroyl, methylidene)‐3‐aryl‐5‐dicyanomethylene thiazolidine‐4‐on derivatives 2 under morpholine treatment formed complex 3. The acid hydrolysis of 3 leads to pyrrolo [3,4‐c]‐pyridine derivatives 4. On treatment of 3 with aqueous sodium hydroxide and subsequent acidification [3,4‐c]pyridine derivatives 5 are formed.

Cycloaddition of 3-Amino-5-chloro-2(1H)-pyrazinones and Olefins: Ring Transformation into 3-Amino- or 6-Cyano-Substituted 2-Pyridinone Systems

“…Reaction in dry pyridine afforded the expected diethylamino derivative 27 . Compounds of type 26 and 27 have been described scarcely and are not easily accessible …”