Polycarbonate nanoplastics and the in vitro assessment of their toxicological impact on liver functionality

Abstract

Polycarbonate photodegradation products, namely nanoplastics and molecular by-products, are formed in a single step. Studying their effects in a suitable hepatic model proves that both components induce toxicity toward hepatocellular functions.

Low-Temperature Methanolysis of Polycarbonate over Solid Base Sodium Aluminate

“…Notably, the use and disposal of polycarbonate (PC), which is one of the top engineering plastics, has increased over the years due to the fast-growing emerging industries coupled with the increased demand for biomedical devices and personal protection equipment during the COVID-19 period . Indeed, landfilled PC plastic not only leads to an inaesthetic environment but also generates micro- and nanoplastics that humans, mammals, and marine animals can easily ingest, which leads to adverse effects on their health . For instance, in the water system, bisphenol A (BPA) may leach and act as an endocrine disruptor chemical (EDC) that leads to infertility, obesity, breast and prostate cancer, and disorders in a metabolic system such as polycystic ovary syndrome (PCOS) if ingested. − Therefore, even temporary landfilling has an adverse effect on both the environment and human health, and immediate recycling of PC plastics is indispensable.…”

“… 3 For instance, in the water system, bisphenol A (BPA) may leach and act as an endocrine disruptor chemical (EDC) that leads to infertility, obesity, breast and prostate cancer, and disorders in a metabolic system such as polycystic ovary syndrome (PCOS) if ingested. 3 − 5 Therefore, even temporary landfilling has an adverse effect on both the environment and human health, and immediate recycling of PC plastics is indispensable.…”