Polycaprolactone nanoparticles containing encapsulated progesterone prepared using a scCO2 emulsion drying technique

Guilherme, Marcos R.; Maurício, Marcos R.; Tenório‐Neto, Ernandes T.; Kunita, Marcos H.; Cardozo‐Filho, Lúcio; Cellet, Thelma S.P.; Pereira, Guilherme M.; Muniz, Edvani C.; Rocha, Sandro R. P. da; Rubira, Adley F.

doi:10.1016/j.matlet.2014.03.099

Cited by 18 publications

(9 citation statements)

References 19 publications

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“…A way of doing this is to dry the particles in scCO 2 [69,86]. Beyond providing porous particles, supercritical drying also is an efficient approach to prepare small particles with narrow particle size distribution, as compared to traditional solvent evaporation of emulsions used in the production of polymeric nanoparticles [87]. In scCO 2 , the original configurations of the polymer chains are kept owing to a fast removal of solvents from emulsion by the solubilization in the scCO 2 phase.…”

Section: Polysaccharide-based Hydrogels Prepared By Scco 2 -Assisted mentioning

confidence: 99%

Superabsorbent hydrogels based on polysaccharides for application in agriculture as soil conditioner and nutrient carrier: A review

Guilherme

Aouada

Fajardo

et al. 2015

European Polymer Journal

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551

304

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a b s t r a c t Superabsorbent hydrogels (SH) continue being a very important issue in both academic and industrial fields due to their applications in several technologies. This is proved by the impressive number of publications, through papers and patents as well, dealing with SH. This review is targeted to update and discuss some important aspects of synthesis, characterization and application of SH in agriculture, mainly those based on polysaccharides, as soil conditioners and as polymer carriers for nutrient release. Basic properties of SH and some methods for chemically modifying polysaccharides are given and some directions for hydrogels preparation are highlighted as well. Mechanisms associated with water transport into the 3D matrix, taking into account the transference of mass from hydrogelsoil system to plant, are discussed in the light of some mathematical models. Release of nutrients either from granules coated by hydrophilic polymer or from SH, targeting applications in agriculture, is also discussed on the basis of often used mathematical models (the swelling-based kinetic models) and on a diffusion-based kinetic model with a partition activity coefficient. Examples of recent applications in agriculture as soil conditioners and carriers for nutrient release (fertilizers, etc.) are given. At the final, future trends and perspectives are considered. More than two hundreds references are cited in the whole text.

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Section: Polysaccharide-based Hydrogels Prepared By Scco 2 -Assisted mentioning

confidence: 99%

Superabsorbent hydrogels based on polysaccharides for application in agriculture as soil conditioner and nutrient carrier: A review

Guilherme

Aouada

Fajardo

et al. 2015

European Polymer Journal

Self Cite

551

304

View full text Add to dashboard Cite

show abstract

“…Polymeric nanoparticles are ultrafine colloidal particles with the size range between 1–1000 nm and have different properties compared to their source materials, in which the therapeutic agents can be entrapped intra‐nanoparticles or can be incorporated via adsorption or chemical conjugation to the surface . Not only the synthetic polymers such as poly(lactide‐co‐glycolide) , polyacrylates , polycaprolactones and polyethylenimine but also natural polymers such as proteins , nucleic acids and polysaccharides have been used to prepare nanoparticulate drug/gene carriers. Over the years, it has been highlighted that nanoparticles frequently exhibit improved properties for easier translocation across biological barriers as they have the advantages of high surface area/volume ratio and increased mobility, and hence a great interactive potential with the biological surfaces .…”

Section: Introductionmentioning

confidence: 99%

Overviews on the cellular uptake mechanism of polysaccharide colloidal nanoparticles

Salatin

Khosroushahi

2017

J Cellular Molecular Medi

228

136

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Nanoparticulate drug/gene carriers have gained much attention in the past decades because of their versatile and tunable properties. However, efficacy of the therapeutic agents can be further enhanced using naturally occurring materials‐based nanoparticles. Polysaccharides are an emerging class of biopolymers; therefore, they are generally considered to be safe, non‐toxic, biocompatible and biodegradable. Considering that the target of nanoparticle‐based therapeutic strategies is localization of biomedical agents in subcellular compartments, a detailed understanding of the cellular mechanism involved in the uptake of polysaccharide‐based nanoparticles is essential for safe and efficient therapeutic applications. Uptake of the nanoparticles by the cellular systems occurs with a process known as endocytosis and is influenced by the physicochemical characteristics of nanoparticles such as size, shape and surface chemistry as well as the employed experimental conditions. In this study, we highlight the main endocytosis mechanisms responsible for the cellular uptake of polysaccharide nanoparticles containing drug/gene.

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“…El comportamiento térmico del PCL durante el análisis DSC se puede observar en la figura 3b, en donde se identifica la temperatura de fusión en 65.35°C y la temperatura de oxidación fue de aproximadamente 387.89°C. La temperatura de fusión encontrada es similar a la encontrada en estudios previos [16], sin embargo se puede notar que el cambio entalpático sufrido por el PCL durante el calentamiento hasta esta temperatura no fue tan grande como el del PVA. Esto hace pensar que si bien el material funde a una temperatura de aprox.…”

Section: Resultados Y Discusión Caracterización De Los Materiales Anáunclassified

Fabricación de filamentos de PCL y PVA reforzados con HAp para ser usados en impresión 3D

Guillén-Girón¹

2018

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El objetivo principal de este trabajo fue la fabricación de filamentos de alcohol polivinílico (PVA) y policaprolactona (PCL) para ser usados en impresión 3D con tecnología de modelado por deposición fundida de filamentos (FDM). El estudio se orientó primeramente en fabricar los filamentos de estos biopolímeros por extrusión y posteriormente estos se reforzaron internamente con hidroxiapatita (HAp) para así mejorar sus propiedades mecánicas. Previo al proceso de manufactura, el PVA, PCL y HAp se caracterizaron usando difracción de rayos-X para evidenciar el grado de ordenamiento cristalográfico de las cadenas poliméricas. La espectroscopia infrarroja se usó para observar los grupos funcionales presentes en estos polímeros y consecuentemente su posible influencia durante el procesamiento por extrusión. Análisis térmicos fueron vitales para establecer las condiciones de manufactura incluyendo la temperatura de fusión y degradación de estos polímeros y HAp. Finalmente, los filamentos fueron analizados por microscopia electrónica. Este estudio permitió evidenciar los retos aun existentes en la manufactura de implantes por medio de impresión 3D usando biopolímeros. Los resultados obtenidos demuestran que atención cuidadosa debe brindarse a la obtención de los filamentos de estos biomateriales para desarrollar futuramente implantes funcionales y personalizados.

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Polycaprolactone nanoparticles containing encapsulated progesterone prepared using a scCO2 emulsion drying technique

Cited by 18 publications

References 19 publications

Superabsorbent hydrogels based on polysaccharides for application in agriculture as soil conditioner and nutrient carrier: A review

Superabsorbent hydrogels based on polysaccharides for application in agriculture as soil conditioner and nutrient carrier: A review

Overviews on the cellular uptake mechanism of polysaccharide colloidal nanoparticles

Fabricación de filamentos de PCL y PVA reforzados con HAp para ser usados en impresión 3D

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