Polycaprolactone/multi-walled carbon nanotube nerve guidance conduits with tunable channels fabricated via novel extrusion-stretching method for peripheral nerve repair

Zhang, Longfei; Sun, Renyuan; Wang, Baolin; Lang, Yuna; Chang, Ming‐Wei

doi:10.1080/00914037.2023.2196626

International Journal of Polymeric Materials and Polymeric Biom

2023

DOI: 10.1080/00914037.2023.2196626

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Polycaprolactone/multi-walled carbon nanotube nerve guidance conduits with tunable channels fabricated via novel extrusion-stretching method for peripheral nerve repair

Longfei Zhang

Renyuan Sun

Baolin Wang

et al.

Abstract: 2023). Polycaprolactone/multi-walled carbon nanotube nerve guidance conduits with tunable channels fabricated via novel extrusion-stretching method for peripheral nerve repair.

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2024

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Intelligent design of nerve guidance conduits: An artificial intelligence‐driven fluid structure interaction study on modelling and optimization of nerve growth

Hassani,

Golshani,

Mehrabi

et al. 2024

Can J Chem Eng

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Nerve guidance conduits (NGCs) have been shown to be effective in promoting nerve regeneration in a variety of clinical applications, including nerve defects resulting from a trauma or surgery. By providing a conducive environment for nerve growth, NGCs can help to restore function in nerve‐damaged patients. Challenges include limited repair length, difficulty replicating natural nerve, and rapid substance degradation affecting neurotrophic factor delivery. Considering these issues with mass transfer and fluid structure interaction (FSI) emphasizes the need for enhancing nerve regeneration efficiency. To facilitate nerve growth and deliver appropriate amount of growth factors, these conduits need to be designed with specific topological, mechanical, and biological properties. Additionally, considerations must be given to functional mass transfer FSI design. An intelligent NGC design is proposed as an evaluation‐optimization and AI‐based method. It is found that design parameters significantly impact the physical properties being optimized, including hydraulic pressure, porosity, diffusivity, water absorption, and maximum stress. The mathematical surrogate model obtained from data‐based modelling is used for artificial intelligence (AI) optimization algorithms, differential evolution (DE), and non‐dominated sorting genetic algorithm II (NSGA‐II). It is revealed that both DE and NSGA algorithms generate nearly identical solutions, ensuring the robustness of ML optimization. Our results show that NGC with the thickness of 750 μm results in more than 170% augmentation of porosity. Moreover, at a constant ovality, increasing the channel thickness results in more than 39.2% augmentation of the maximum stress. The accurate forecasting of physical characteristics on NGC regarding nerve growth factors enables a hopeful outlook for the future clinical treatment of nerve injuries and advanced tissue engineering.

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Intelligent design of nerve guidance conduits: An artificial intelligence‐driven fluid structure interaction study on modelling and optimization of nerve growth

Hassani,

Golshani,

Mehrabi

et al. 2024

Can J Chem Eng

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show abstract

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Polycaprolactone/multi-walled carbon nanotube nerve guidance conduits with tunable channels fabricated via novel extrusion-stretching method for peripheral nerve repair

Abstract: 2023). Polycaprolactone/multi-walled carbon nanotube nerve guidance conduits with tunable channels fabricated via novel extrusion-stretching method for peripheral nerve repair.

Cited by 1 publication

References 29 publications

Intelligent design of nerve guidance conduits: An artificial intelligence‐driven fluid structure interaction study on modelling and optimization of nerve growth

Intelligent design of nerve guidance conduits: An artificial intelligence‐driven fluid structure interaction study on modelling and optimization of nerve growth

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