Polycaprolactone-based Nanocarriers Containing 5-fluorouracil as a Therapeutic Guided Drug Delivery Approach for Enhancing Anticancer Activity

Abstract

Nowadays, nano-platforms designed for drug delivery systems (DDSs) such as polymers, liposomes, and micelles have been demonstrated to be clinically efficient. The sustained drug release is one of the advantages of DDSs, especially polymer-based nanoparticles. The formulation could enhance the drug's durability, in which the biodegradable polymers are the most interesting building blocks of DDSs. Nano-carriers could circumvent many issues by localized drug delivery and release via certain internalization routes such as intracellular endocytosis paths and increasing biocompatibility. Polymeric nanoparticles and their nanocomposite are one of the most important classes of materials that can be used for the assembly of nanocarriers that can form complex, conjugated and encapsulated forms. The site-specific drug delivery may arise from the ability of nanocarriers to pass through the biological barrier, their specific interactions with receptors, and passive targeting. The better circulation, uptake, and stability along with targeting attributes lead to lesser side effects and damage to normal cells. Hence, in this review, the most recent achievements on polycaprolactone-based or -modified nanoparticles in drug delivery systems (DDSs) for 5-fluorouracil (5-FU) are presented.

Different Drug Mobilities in Hydrophobic Cavities of Host–Guest Complexes between β-Cyclodextrin and 5-Fluorouracil at Different Stoichiometries: A Molecular Dynamics Study in Water

“…1 mg/mL) [ 58 ]. Appropriate carriers or substrates can enhance its bioavailability and mitigate the development of serious side effects [ 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 ]. Molecular simulations of the adsorption process of 5-FU on graphene oxide nanosheets as a drug delivery vehicle [ 72 ], MD simulations related to hydrophilic pores in phospholipid bilayers and Fe 3 O 4 nanoparticles loaded with 5-FU [ 73 ], and investigations into the adsorption of 5-FU on gold clusters [ 74 , 75 ] have attracted attention.…”

Toxicity Evaluation and Controlled-Release of Curcumin-Loaded Amphiphilic Poly-N-vinylpyrrolidone Nanoparticles: In Vitro and In Vivo Models

“…Despite the well-studied chemistry of PEG, there is currently an active search for alternative polymers/copolymers for the delivery of physiologically active substances with similar properties. Polylactide [ 4 , 5 ], poly(lactide-co-glycolide) [ 6 , 7 , 8 ], poly(ε-caprolactone) [ 9 , 10 ] and others are also used as carriers.…”

Toxicity Evaluation and Control Release of Curcumin-Loaded Amphiphilic Poly-n-vinylpyrrolidone Nanoparticles for the Treatment of Malignant Tumors: In Vitro and In Vivo Models

“…Despite the well-studied chemistry of PEG, there is currently an active search for alternative polymers/copolymers for the delivery of physiologically active substances with similar properties. Polylactide [4,5], poly-lactide-co-glycolide [6][7][8], poly-εcaprolactone [9,10] and others are also used as carriers.…”