Polycaprolactone-Based Mimetic Antimicrobial Peptide Copolymers Vesicles as an Effective Drug-Carrier for Cancer Therapy

Qian, Yusheng; Zhou, Xinyu; He, Jing; Zhou, Chuncai

doi:10.3390/polym11111783

Cited by 7 publications

(3 citation statements)

References 42 publications

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“…A similar behavior was also observed by Li et al, who reported between 30 and 40% release of doxorubicin from nanodiamonds within a similar time frame. Such sustained release is known for many different drug delivery nanoparticles. − Similar release behavior from diamond particles was also already observed in the literature. Huang et al, Wang et al, and Li et al, for instance, described slow release of doxorubicin that was attached to nanodiamonds. ,, While in this simplified case, the drug was released by hydrolysis of the amide bond that connects the drug molecule with the diamond surface, there are more factors that play a role in cancer in vivo.…”

Section: Resultssupporting

confidence: 74%

Functionalized Fluorescent Nanodiamonds for Simultaneous Drug Delivery and Quantum Sensing in HeLa Cells

Tian

Nusantara

Hamoh

et al. 2022

ACS Appl. Mater. Interfaces

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Here, we present multifunctional fluorescent nanodiamonds (FNDs) for simultaneous drug delivery and free radical detection. For this purpose, we modified FNDs containing nitrogen vacancy (NV) centers with a diazoxide derivative. We found that our particles enter cells more easily and are able to deliver this cancer drug into HeLa cells. The particles were characterized by infrared spectroscopy, dynamic light scattering, and secondary electron microscopy. Compared to the free drug, we observe a sustained release over 72 h rather than 12 h for the free drug. Apart from releasing the drug, with these particles, we can measure the drug's effect on free radical generation directly. This has the advantage that the response is measured locally, where the drug is released. These FNDs change their optical properties based on their magnetic surrounding. More specifically, we make use of a technique called relaxometry to detect spin noise from the free radical at the nanoscale with subcellular resolution. We further compared the results from our new technique with a conventional fluorescence assay for the detection of reactive oxygen species. This provides a new method to investigate the relationship between drug release and the response by the cell via radical formation or inhibition.

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Section: Resultssupporting

confidence: 74%

Functionalized Fluorescent Nanodiamonds for Simultaneous Drug Delivery and Quantum Sensing in HeLa Cells

Tian

Nusantara

Hamoh

et al. 2022

ACS Appl. Mater. Interfaces

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“…Considering the unique structure of polymer vesicles with hydrophilic interior cavity and hydrophobic membrane, antimicrobial polymer vesicles are ideal candidates to encapsulate and deliver functional cargoes such as antibiotics, drugs, and other biomacromolecules to realize specific functions while maintaining the antimicrobial activity of the carriers [ 109 ]. The encapsulation of antibiotics to enhance the antimicrobial activity of polymer vesicles has been discussed in Section 2.2 .…”

Section: Antimicrobial Applications Of Polymer Vesiclesmentioning

confidence: 99%

Polymer Vesicles for Antimicrobial Applications

2021

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Polymer vesicles, hollow nanostructures with hydrophilic cavity and hydrophobic membrane, have shown significant potentials in biomedical applications including drug delivery, gene therapy, cancer theranostics, and so forth, due to their unique cell membrane-like structure. Incorporation with antibacterial active components like antimicrobial peptides, etc., polymer vesicles exhibited enhanced antimicrobial activity, extended circulation time, and reduced cell toxicity. Furthermore, antibacterial, and anticancer can be achieved simultaneously, opening a new avenue of the antimicrobial applications of polymer vesicles. This review seeks to highlight the state-of-the-art of antimicrobial polymer vesicles, including the design strategies and potential applications in the field of antibacterial. The structural features of polymer vesicles, preparation methods, and the combination principles with antimicrobial active components, as well as the advantages of antimicrobial polymer vesicles, will be discussed. Then, the diverse applications of antimicrobial polymer vesicles such as wide spectrum antibacterial, anti-biofilm, wound healing, and tissue engineering associated with their structure features are presented. Finally, future perspectives of polymer vesicles in the field of antibacterial is also proposed.

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“…The cytotoxicity tests conducted on human dermal fibroblasts for 72 h showed that even at 500 μg/mL PCL 16 -b-K 20 concentration (fifty times higher than MIC activity), more than 70% of the normal human cells were still alive [ 165 ]. It was also shown that PCL 16 -b-K n copolymer vesicles exhibit the value of a potential application as multifunctional drug-carrier systems with antibacterial capability in cancer therapy [ 169 ].…”

Section: Amino Acid Conjugated Polymersmentioning

confidence: 99%

The Best Peptidomimetic Strategies to Undercover Antibacterial Peptides

Lachowicz

Szczepski

Scano

et al. 2020

IJMS

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Health-care systems that develop rapidly and efficiently may increase the lifespan of humans. Nevertheless, the older population is more fragile, and is at an increased risk of disease development. A concurrently growing number of surgeries and transplantations have caused antibiotics to be used much more frequently, and for much longer periods of time, which in turn increases microbial resistance. In 1945, Fleming warned against the abuse of antibiotics in his Nobel lecture: “The time may come when penicillin can be bought by anyone in the shops. Then there is the danger that the ignorant man may easily underdose himself and by exposing his microbes to non-lethal quantities of the drug make them resistant”. After 70 years, we are witnessing the fulfilment of Fleming’s prophecy, as more than 700,000 people die each year due to drug-resistant diseases. Naturally occurring antimicrobial peptides protect all living matter against bacteria, and now different peptidomimetic strategies to engineer innovative antibiotics are being developed to defend humans against bacterial infections.

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Polycaprolactone-Based Mimetic Antimicrobial Peptide Copolymers Vesicles as an Effective Drug-Carrier for Cancer Therapy

Cited by 7 publications

References 42 publications

Functionalized Fluorescent Nanodiamonds for Simultaneous Drug Delivery and Quantum Sensing in HeLa Cells

Functionalized Fluorescent Nanodiamonds for Simultaneous Drug Delivery and Quantum Sensing in HeLa Cells

Polymer Vesicles for Antimicrobial Applications

The Best Peptidomimetic Strategies to Undercover Antibacterial Peptides

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