Polycaprolactone- and polycaprolactone/ceramic-based 3D-bioplotted porous scaffolds for bone regeneration: A comparative study

Gómez-Lizárraga, K.; Flores-Morales, Carlos; Prado-Audelo, María Luisa Del; Álvarez-Pérez, Marco Antonio; Piña-Barba, María C.; Escobedo, Carlos

doi:10.1016/j.msec.2017.05.003

Cited by 106 publications

(77 citation statements)

References 48 publications

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“…Regarding the pore size, the distance between filaments was in the range of 400–425 μm for all the groups of scaffolds evaluated (Table ), so according to previous literature, the structures obtained fulfil the requirements for bone regeneration (150–500 μm) (Gómez‐Lizárraga et al, ). In addition, apparent density values (0.53–0.55 g/cm 3 , Table ) were within the range reported for cancellous bone, 0.14–1.2 g/cm 3 (Deplaine et al, ), as well as compressive test results for all the groups of scaffolds tested (Leong et al, ).…”

Section: Discussionsupporting

confidence: 53%

Comparison between calcium carbonate and β‐tricalcium phosphate as additives of 3D printed scaffolds with polylactic acid matrix

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Monzón

Wang

et al. 2019

J Tissue Eng Regen Med

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In this study, polylactic acid (PLA)‐based composite scaffolds with calcium carbonate (CaCO3) and beta‐tricalcium phosphate (β‐TCP) were obtained by 3D printing. These structures were evaluated as potential 3D structures for bone tissue regeneration. Morphological, mechanical, and biological tests were carried out in order to compare the effect of each additive (added in a concentration of 5% w/w) and the combination of both (2.5% w/w of each one), on the PLA matrix. The scaffolds manufactured had a mean pore size between 400–425 μm and a porosity value in the range of 50–60%. According to the results, both additives promoted an increase of the porosity, hydrophilicity, and surface roughness of the scaffolds, leading to a significant improvement of the metabolic activity of human osteoblastic osteosarcoma cells. The best results in terms of cell attachment after 7 days were obtained for the samples containing CaCO3 and β‐TCP particles due to the synergistic effect of both additives, which results in an increase in osteoconductivity and in a microporosity that favours cell adhesion. These scaffolds (PLA:CaCO3:β‐TCP 95:2.5:2.5) have suitable properties to be further evaluated for bone tissue engineering applications.

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Section: Discussionsupporting

confidence: 53%

Comparison between calcium carbonate and β‐tricalcium phosphate as additives of 3D printed scaffolds with polylactic acid matrix

Donate

Monzón

Wang

et al. 2019

J Tissue Eng Regen Med

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“…One of the ways to overcome these problems is to add ceramics such as β‐tricalcium phosphate (β‐TCP) to the PCL to increase hydrophilicity, osteoconductivity, and the degradation rate to promote bone formation . Many previous studies showed that the ceramic addition to these polymers enhanced the bone formation as well as the adhesion and proliferation of preosteoblast cells …”

Section: Introductionmentioning

confidence: 99%

3D‐printed polycaprolactone scaffold mixed with β‐tricalcium phosphate as a bone regenerative material in rabbit calvarial defects

et al. 2018

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Defect-specific bone regeneration using 3-dimensional (3D) printing of block bone has been developed. Polycaprolactone (PCL) is biocompatible polymer that can be used as 3D scaffold. The aim of this study is to assess the biocompatibility and osteogenic efficacy of 3D printed PCL scaffold and to evaluate the effectiveness of β-tricalcium phosphate (β-TCP) addition in PCL scaffold. In this work, four circular defects (diameter: 8 mm) in rabbit calvarium were randomly assigned to (1) negative control (control), (2) PCL block (PCL), (3) PCL mixed with 10 wt% β-TCP (PCL/β-TCP), and (4) PCL/β-TCP plus collagen membrane (PCL/β-TCP + M). Animals were euthanized at 2 (n = 5) and 8 weeks (n = 5). Results indicated that in micro-CT, PCL/β-TCP + M showed the highest total augmented volume and new bone volume at 8 weeks, but there was no significant difference among four groups. Histomorphometrically, PCL, PCL/β-TCP, and PCL/β-TCP + M showed the significantly higher total augmented area compared to the control. PCL/β-TCP + M showed the highest new bone area but not statistically higher than the control. New bone formation deep inside the scaffold was observed only in β-TCP added scaffold. PCL showed high biocompatibility with great volume maintenance. Addition of β-TCP to PCL seemed to increase hydrophilicity and osteoconductivity. Developments in 3D-printed PCL material are expected.

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“…Biocompatibility studies the properties of a product when it makes contact with the biological environment. The factors that should be considered include, but are not restrict to, cellular growth and proliferation, cellular adherence, in vitro cellular toxicity, and degradation. It should be noted that some of the in vitro tests might be processed in a excessive strict condition compared to the practical conditions.…”

Section: Biocompatibilitymentioning

confidence: 99%

Pre‐Registration Assessment of Bone‐Filling Products

Pan

Liu

Yang

et al. 2019

Orthopaedic Surgery

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The use of bone‐filling material to repair bone defects and fix implanted bone grafts is a developing area in medicine. Investigators can evaluate bone‐filling materials through use of several indices to make comparisons and to determine suitability for application in humans1. However, it is quite difficult to transform their discovery into practical use, because the viability of the studied material might require examination of all aspects of properties. In addition, for a material to become a product, a complete procedure involving a declaration, registration, and approval is necessary. This article introduces the technical indices that the investigators and reporters should provide in their declaration and registration data to meet the relevant standards in China. The indices include physical and chemical properties, biocompatibility, biosecurity, pre‐clinical animal model tests, sterilization and disinfection, product duration, and packaging. Full consideration of all possible indices is crucial to realize the transformation from a designed product to a commercial medical device, which requires effective interaction between clinicians and engineers.

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Polycaprolactone- and polycaprolactone/ceramic-based 3D-bioplotted porous scaffolds for bone regeneration: A comparative study

Cited by 106 publications

References 48 publications

Comparison between calcium carbonate and β‐tricalcium phosphate as additives of 3D printed scaffolds with polylactic acid matrix

Comparison between calcium carbonate and β‐tricalcium phosphate as additives of 3D printed scaffolds with polylactic acid matrix

3D‐printed polycaprolactone scaffold mixed with β‐tricalcium phosphate as a bone regenerative material in rabbit calvarial defects

Pre‐Registration Assessment of Bone‐Filling Products

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