Polybrominated diphenyl ethers in serum from residents living in a brominated flame retardant production area: Occurrence, influencing factors, and relationships with thyroid and liver function

Zhao, Xuezhen; Yang, Xiaodi; Du, Yinglin; Li, Renbo; Wang, Yuwei; Tian, Chen; Wang, Dejun; Shi, Zhixiong

doi:10.1016/j.envpol.2020.116046

Cited by 47 publications

(23 citation statements)

References 79 publications

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“…It has previously been found that the BMI and alcohol consumption are related to the concentrations of pollutants such as PBDEs in serum. − However, the relationships between the BMI and alcohol intake and the concentration of DP in human serum are unclear. The BMI is used around the world to assess the degree to which a person is overweight or underweight.…”

Section: Resultsmentioning

confidence: 99%

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Effect of Affinity between Dechlorane Plus and Human Serum Albumin on Its Serum Concentration in a General Population

Bao

Hou

Wang

et al. 2022

Environ. Sci. Technol.

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Dechlorane Plus (DP) has been detected in human serum around the world. Determining how DP binds to human serum albumin (HSA) could improve our understanding of the effects of DP in humans. The results of a fluorescence titration experiment indicated that DP binds to HSA at the interface between domains IIA and IIB, and HSA has more affinity for anti-DP than syn-DP. The DP concentrations in serum from 33 people living in Wuxi City, China, were determined in five consecutive years (2012–2016). The total concentrations of the two DP isomers were 1.73–16.3 ng·g–1 lipid weight (mean 4.7 ng·g–1 lipid weight). No clear increasing or decreasing temporal trend was found in the DP concentrations in serum over the study period. The affinity between DP and HSA will increase as the amount of fatty acids combined with HSA increases. This explained the syn-DP and anti-DP concentrations in serum being higher for overweight people than for normal weight people. Ethanol can occupy the DP binding sites on HSA. This explained the syn-DP and anti-DP concentrations being lower for alcoholic people than for nonalcoholic people.

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Section: Resultsmentioning

confidence: 99%

“…Positive correlations between PBDE concentrations in serum and the body mass index (BMI) have been found in some studies, , but negative correlations have been found in other studies . A relationship between high alcohol intake and high PBDE concentrations has been found in only one study .…”

Section: Introductionmentioning

confidence: 99%

Effect of Affinity between Dechlorane Plus and Human Serum Albumin on Its Serum Concentration in a General Population

Bao

Hou

Wang

et al. 2022

Environ. Sci. Technol.

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“…This result is consistent with several experimental studies showing apparent nonmonotonic effects of BDE209 in various cell lines and organisms [ 28 , 29 , 30 , 31 ]. In consideration of the fact that an environmentally relevant serum concentration of BDE209 in humans has a low threshold, we focused mainly on the effects and mechanism of low concentrations of BDE209 on the thyroid [ 19 , 32 ]. Moreover, long-term BDE209 exposure (≥27 days) was used to explore the chronic toxicity of BDE209 on normal human thyroid and the PTC cell lines, the effects of which are difficult to determine in experimental settings in humans [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

“…Decabromodiphenyl ether (BDE209) is the most commonly used PBDEs and it has been widely detected in multiple environmental media and biological samples ranging from plankton to mammals [ 16 , 17 , 18 ]. As the most important PBDEs in serum and plasma, BDE209 has been demonstrated to be associated with thyroid dysfunction and thyroid carcinoma risk [ 18 , 19 ]. However, the exact effects and underlying mechanisms of this remain unknown.…”

Section: Introductionmentioning

confidence: 99%

Long-Term Exposure to Decabromodiphenyl Ether Promotes the Proliferation and Tumourigenesis of Papillary Thyroid Carcinoma by Inhibiting TRß

Wang

Cui

Zhao

et al. 2022

Cancers

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Polybrominated diphenyl ethers (PBDEs) have been reported to possess endocrine-disrupting and tumour-promoting activity. However, the effects of long-term exposure to decabromodiphenyl ether (BDE209) on thyroid tumourigenesis of papillary thyroid carcinoma (PTC) and the underlying mechanisms remain poorly defined. In this study, functional assays in vitro and mouse models in vivo were used to evaluate the toxic effects of long-term exposure to environmental concentrations of BDE209 on the pathogenesis and progression of PTC. MTS, EdU and colony-forming assays confirmed the chronic toxicity of BDE209 on the proliferation of human normal follicular epithelial cell line (Nthy-ori 3-1) and PTC-derived cell lines (TPC-1 and BCPAP). Wound and Transwell assays showed that BDE209 exacerbated the aggressiveness of PTC cells. BDE209 significantly promoted cell proliferation during the S and G2/M phases of the cell cycle. Mechanistically, BDE209 altered the thyroid system by acting as a competitive inhibitor of thyroid receptor beta (TRß) expression and function, which was further proven by public databases and RNA-seq bioinformation analysis. Taken together, these results demonstrated that BDE209 has chronic toxicity and potential tumourigenic effects on the thyroid by inhibiting TRß.

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“…Since PBDEs are structurally similar to endogenous thyroid hormone, they primarily target the thyroid system [14]. Thyroid hormones gradually fade away for high doses of PBDEs, and bind to thyroid hormone receptors and transporter proteins [15][16][17]. Furthermore, exposure to endocrine disruptors is associated with cancer risk in various tissues, and the activation of environmental estrogen fast signals can result in epigenetic reprogramming and develop to breast carcinoma [18].…”

Section: Introductionmentioning

confidence: 99%

Bioinformatic analyses of hydroxylated polybrominated diphenyl ethers toxicities on impairment of adrenocortical secretory function

Cai

Wei

et al. 2022

Environ. Health Prev. Med.

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Background: Polybrominated diphenyl ethers (PBDEs) and their metabolites have severe impact on human health, but few studies focus on their nephrotoxicity. This study was conceived to explore hub genes that may be involved in two hydroxylated polybrominated diphenyl ethers toxicities on impairment of adrenocortical secretory function. Methods: Gene dataset was obtained from Gene Expression Omnibus (GEO). Principal component analysis and correlation analysis were used to classify the samples. Differentially expressed genes (DEGs) were screened using the limma package in RStudio (version 4.1.0). Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) and Reactome enrichment analyses of DEGs were conducted. Protein-protein interaction (PPI) network was established using STRING network, and genes were filtered by Cytoscape (version 3.8.2). Finally, the hub genes were integrated by plug-in CytoHubba and RobustRankAggreg, and were preliminarily verified by the Comparative Toxicogenomics Database (CTD). Results: GSE8588 dataset was selected in this study. About 190 upregulated and 224 downregulated DEGs in 2-OH-BDE47 group, and 244 upregulated and 276 downregulated DEGs in 2-OH-BDE85 group. Functional enrichment analyses in the GO, KEGG and Reactome indicated the potential involvement of DEGs in endocrine metabolism, oxidative stress mechanisms, regulation of abnormal cell proliferation, apoptosis, DNA damage and repair. 2-OH-BDE85 is more cytotoxic in a dose-dependent manner than 2-OH-BDE47. A total of 98 hub genes were filtered, and 91 nodes and 359 edges composed the PPI network. Besides, 9 direct-acting genes were filtered for the intersection of hub genes by CTD. Conclusions: OH-PBDEs may induce H295R adrenocortical cancer cells in the disorder of endocrine metabolism, regulation of abnormal cell proliferation, DNA damage and repair. The screened hub genes may play an important role in this dysfunction.

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Polybrominated diphenyl ethers in serum from residents living in a brominated flame retardant production area: Occurrence, influencing factors, and relationships with thyroid and liver function

Cited by 47 publications

References 79 publications

Effect of Affinity between Dechlorane Plus and Human Serum Albumin on Its Serum Concentration in a General Population

Effect of Affinity between Dechlorane Plus and Human Serum Albumin on Its Serum Concentration in a General Population

Long-Term Exposure to Decabromodiphenyl Ether Promotes the Proliferation and Tumourigenesis of Papillary Thyroid Carcinoma by Inhibiting TRß

Bioinformatic analyses of hydroxylated polybrominated diphenyl ethers toxicities on impairment of adrenocortical secretory function

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