Polybetaine-enhanced hybrid ionomer cement shows improved total biological effect with bacterial resistance and cellular stimulation

Mangal, Utkarsh; Kang, Tae Yun; Jung, Ju Won; Kim, Ji Yeong; Seo, Ji‐Young; Yul, Jung; Lee, Kee‐Joon; Yu, Hyung Seog; Kim, Kwang Mahn; Kim, Jin Man; Kwon, Jae‐Sung; Choi, Sung‐Hwan

doi:10.1039/d2bm01428a

Cited by 2 publications

(1 citation statement)

References 41 publications

(67 reference statements)

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“…The sample images were observed using the confocal fluorescence microscope (LSM 900, Carl Zeiss, Thornwood, NY, United States). The recorded images were analyzed, and the fluorescence intensity was quantified (geometric mean) using the software Zen (version 3.4, Blue edition, Carl Zeiss, Jena, Germany) in accordance with the previous study 41 .…”

Section: Methodsmentioning

confidence: 99%

Cerium doping of 45S5 bioactive glass improves redox potential and cellular bioactivity

Ryu,

Kang,

Choi

et al. 2024

Sci Rep

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Abstract45S5 Bioglass (BG) is composed of a glass network with silicate based on the component and can be doped with various therapeutic ions for the enhancement of hard tissue therapy. Nanoceria (CeO2) has been shown to indicate redox reaction and enhance the biological response. However, few studies focus on the proportion of CeO2-doped and its effect on the cellular bioactivity of CeO2-doped BG (CBG). In this study, we synthesized the CBG series with increasing amounts of doping CeO2 ranging (1 to 12) wt.%. The synthesized CBG series examined the characterization, mineralization capacity, and cellular activity against BG. Our results showed that the CBG series exhibited a glass structure and indicated the redox states between Ce3+ and Ce4+, thus they showed the antioxidant activity by characterization of Ce. The CBG series had a stable glass network structure similar to BG, which showed the preservation of bioactivity by exhibiting mineralization on the surface. In terms of biological response, although the CBG series showed the proliferative activity of pre-osteoblastic cells similar to BG, the CBG series augmented not only the alkaline phosphatase activity but also the osteogenic marker in the mRNA level. As stimulated the osteogenic activity, the CBG series improved the biomineralization. In conclusion, the CBG series might have a potential application for hard tissue therapeutic purposes.

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Section: Methodsmentioning

confidence: 99%

Cerium doping of 45S5 bioactive glass improves redox potential and cellular bioactivity

Ryu,

Kang,

Choi

et al. 2024

Sci Rep

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Occlusive membranes for guided regeneration of inflamed tissue defects

Choi,

Mangal,

Park

et al. 2023

Nat Commun

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Guided bone regeneration aided by the application of occlusive membranes is a promising therapy for diverse inflammatory periodontal diseases. Symbiosis, homeostasis between the host microbiome and cells, occurs in the oral environment under normal, but not pathologic, conditions. Here, we develop a symbiotically integrating occlusive membrane by mimicking the tooth enamel growth or multiple nucleation biomineralization processes. We perform human saliva and in vivo canine experiments to confirm that the symbiotically integrating occlusive membrane induces a symbiotic healing environment. Moreover, we show that the membrane exhibits tractability and enzymatic stability, maintaining the healing space during the entire guided bone regeneration therapy period. We apply the symbiotically integrating occlusive membrane to treat inflammatory-challenged cases in vivo, namely, the open and closed healing of canine premolars with severe periodontitis. We find that the membrane promotes symbiosis, prevents negative inflammatory responses, and improves cellular integration. Finally, we show that guided bone regeneration therapy with the symbiotically integrating occlusive membrane achieves fast healing of gingival soft tissue and alveolar bone.

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Polybetaine-enhanced hybrid ionomer cement shows improved total biological effect with bacterial resistance and cellular stimulation

Abstract: Hybrid ionomer cements (HICs) are aesthetic polyelectrolyte cements that have been modified with a resin. The setting of HICs occurs by both monomer polymerization and an acid–base reaction. In addition,...

Cited by 2 publications

References 41 publications

Cerium doping of 45S5 bioactive glass improves redox potential and cellular bioactivity

Cerium doping of 45S5 bioactive glass improves redox potential and cellular bioactivity

Occlusive membranes for guided regeneration of inflamed tissue defects

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