Polyaspartic acid coated manganese oxide nanoparticles for efficient liver MRI

Xing, Ruijun; Zhang, Fan; Xie, Jin; Aronova, Maria A.; Guo, Ning; Sun, Xiaolian; Liu, Gang; Bryant, L. Henry; Bhirde, Ashwinkumar; Liang, Amy; Hou, Yanglong; Leapman, Richard D.; Sun, Shouheng; Chen, Xiaoyuan

doi:10.1039/c1nr11242b

Cited by 40 publications

(42 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This was verified by the SAED pattern as the diffraction rings were consistent with the structure of MnO (Figure S1c, Supporting Information). Compared to the commonly used 1‐hexadecene and 1‐octadecene solvents, smaller MONs are readily yielded when the hydrocarbon chain length of the alkene solvent is reduced. It is noteworthy that highly monodispersed sub 10 nm MONs are formed by employing 1‐tetradecene as the solvent of high boiling point in our synthesis protocol.…”

Section: Resultsmentioning

confidence: 99%

“…In general, the r 1 relaxivity is expected to increase as the particle size of MONs decreases. For example, Chen and co‐workers found that MONs with a size of 10 nm exhibited a greater positive contrast ability than those with larger sizes . Hollow‐structured MONs are also attractive candidates as T 1 contrast agents because they exhibit high surface‐to‐volume ratio.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A Hybrid Silica Nanoreactor Framework for Encapsulation of Hollow Manganese Oxide Nanoparticles of Superior T₁ Magnetic Resonance Relaxivity

Hsu

Wong

et al. 2015

Adv Funct Materials

View full text Add to dashboard Cite

wileyonlinelibrary.comA new hybrid nanoreactor framework with poly(ethylene oxide)-perforated silica walls is designed to encapsulate hollow manganese oxide nanoparticles (MONs) of high distinctness and homogeneity. Achieved by an interfacial templating scheme, the nanoreactor ensures that acidic etching of MONs by an acetate buffer solution is highly controlled for precise control of the hollow interior. As such, hollow MONs with different nanostructures are developed successfully through a facile acetate buffer solution etching. The resultant hollow MONs are integrated within the hybrid nanoreactor and demonstrate superior r 1 relativity of up to 2.58 m M −1 s −1 for T 1 magnetic resonance imaging (MRI). By modifying the nanoreactor architecture, it is also demonstrated that the effi cacy of MONs as T 1 MRI contrast agents can be signifi cantly improved if an optimal cluster of hollow MONs is encapsulated into the hybrid silica framework. The evolution of core morphology with time is studied to elucidate the etching mechanism. It is revealed that the hollow formation arises due to the surface stabilization of MONs by acetate ions and the subsequent acidic etching of the interior core in a sporadic manner. This is different from the commonly reported nanoscale Kirkendall effect or the selective etching of the core-shell MnO/Mn 3 O 4 structure.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Hybrid Silica Nanoreactor Framework for Encapsulation of Hollow Manganese Oxide Nanoparticles of Superior T₁ Magnetic Resonance Relaxivity

Hsu

Wong

et al. 2015

Adv Funct Materials

View full text Add to dashboard Cite

show abstract

“…Phantom studies indicated contrast enhancement depending on the concentration of both particles and amount of Gd loaded into the construct . Manganese‐based contrast agents surface coated with polymeric nanomaterials are gaining importance to be explored as alternate T1 agents …”

Section: Polymeric Mr Contrast Agentsmentioning

confidence: 99%

Polymeric nanoparticles for molecular imaging

Srikar

Upendran

Kannan

2014

WIREs Nanomed Nanobiotechnol

View full text Add to dashboard Cite

Conventional imaging technologies (X-ray computed tomography, magnetic resonance, and optical) depend on contrast agents to visualize a target site or organ of interest. The imaging agents currently used in clinics for diagnosis suffer from disadvantages including poor target specificity and in vivo instability. Consequently, delivery of low concentrations of contrast agents to region of interest affects image quality. Therefore, it is important to selectively deliver high payload of contrast agent to obtain clinically useful images. Nanoparticles offer multifunctional capabilities to transport high concentrations of imaging probes selectively to diseased site inside the body. Polymeric nanoparticles, incorporated with contrast agents, have shown significant benefits in molecular imaging applications. These materials possess the ability to encapsulate different contrast agents within a single matrix enabling multimodal imaging possibilities. The materials can be surface conjugated to target-specific biomolecules for controlling the navigation under in vivo conditions. The versatility of this class of nanomaterials makes them an attractive platform for developing highly sensitive molecular imaging agents. The research community's progress in the area of synthesis of polymeric nanomaterials and their in vivo imaging applications has been noteworthy, but it is still in the pioneer stage of development. The challenges ahead should focus on the design and fabrication of these materials including burst release of contrasts agents, solubility, and stability issues of polymeric nanomaterials.

show abstract

“…However, recent synthesis of manganese oxide‐based NPs could lead to a resurgence of manganese as an MRI contrast agent, and a recent report by Zhang et al demonstrate the efficacy of Mn 2+ ions as imaging probes for visualizing delivery of cancer therapeutic drugs . Also, manganese oxide NPs (MONPs) are T2/T2 * active CAs, but they also degrade in water within a reasonable time frame (hours to days) . This is interesting for MRI applications because MONPs that degrade, release Mn 2+ ions, which are very efficient T1 CAs .…”

mentioning

confidence: 99%

L‐DOPA‐Coated Manganese Oxide Nanoparticles as Dual MRI Contrast Agents and Drug‐Delivery Vehicles

McDonagh

Singh

Hak

et al. 2015

Small

View full text Add to dashboard Cite

show abstract

Polyaspartic acid coated manganese oxide nanoparticles for efficient liver MRI

Cited by 40 publications

References 14 publications

A Hybrid Silica Nanoreactor Framework for Encapsulation of Hollow Manganese Oxide Nanoparticles of Superior T₁ Magnetic Resonance Relaxivity

A Hybrid Silica Nanoreactor Framework for Encapsulation of Hollow Manganese Oxide Nanoparticles of Superior T₁ Magnetic Resonance Relaxivity

Polymeric nanoparticles for molecular imaging

L‐DOPA‐Coated Manganese Oxide Nanoparticles as Dual MRI Contrast Agents and Drug‐Delivery Vehicles

Contact Info

Product

Resources

About

Polyaspartic acid coated manganese oxide nanoparticles for efficient liver MRI

Cited by 40 publications

References 14 publications

A Hybrid Silica Nanoreactor Framework for Encapsulation of Hollow Manganese Oxide Nanoparticles of Superior T1 Magnetic Resonance Relaxivity

A Hybrid Silica Nanoreactor Framework for Encapsulation of Hollow Manganese Oxide Nanoparticles of Superior T1 Magnetic Resonance Relaxivity

Polymeric nanoparticles for molecular imaging

L‐DOPA‐Coated Manganese Oxide Nanoparticles as Dual MRI Contrast Agents and Drug‐Delivery Vehicles

Contact Info

Product

Resources

About

A Hybrid Silica Nanoreactor Framework for Encapsulation of Hollow Manganese Oxide Nanoparticles of Superior T₁ Magnetic Resonance Relaxivity

A Hybrid Silica Nanoreactor Framework for Encapsulation of Hollow Manganese Oxide Nanoparticles of Superior T₁ Magnetic Resonance Relaxivity