Polyarthritis, Polyarteritis and Hepatitis B

Duffy, John P.; Lidsky,; Jt, Sharp; Js, Davis; Da, Person; Fb, Hollinger; Kw, Min

doi:10.1097/00005792-197601000-00002

Cited by 186 publications

(20 citation statements)

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“…The studies reported here provide a model system to examine the complexities of the immune response to HBsAg and may prove useful in dissecting out the aberrations of the immune response to this clinically relevant antigen which may be involved in immune-mediated diseases associated with hepatitis B virus infection (1)(2)(3)(4)(5)(6).…”

Section: Resultsmentioning

confidence: 99%

“…Several clinical syndromes are associated with the absent or incomplete immune response to HBsAg. Aberrant immune responses to HBsAg that result in immune complex formation and subsequent tissue deposition have been causally implicated in some cases ofcryoglobulinemia (2), glomerulonephritis (3,4), and systemic necrotizing vasculitis (5,6). The association of the chronic HBsAg carrier state and chronic state and chronic hepatitis has also been emphasized (7,8) and extensively investigated (reviewed, 9 and 10).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

In vitro antigen-induced antibody responses to hepatitis B surface antigen in man. Kinetic and cellular requirements.

Cupps¹,

Gerin²,

Purcell³

et al. 1984

J. Clin. Invest.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

In vitro antigen-induced antibody responses to hepatitis B surface antigen in man. Kinetic and cellular requirements.

Cupps¹,

Gerin²,

Purcell³

et al. 1984

J. Clin. Invest.

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“…The only well characterized synovial fluid and synovial histologic findings are in hepatitis B (29,30). The synovial fluid findings from our case are the first described in echovirus-associated arthritis.…”

Section: Discussionmentioning

confidence: 59%

Echovirus‐associated polyarthritis. report of a case with synovial fluid and synovial histologic characterization

1978

Arthritis & Rheumatism

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A patient with fever, myalgias, and acute polyarthritis in whom echovirus 9 was isolated from throat and rectal swab specimens is described. All symptoms resolved spontaneously over a one week period except for the arthritis which required three months for complete recovery. A mildly inflammatory synovial fluid and histologic picture were observed. Attempts to isolate the virus from synovial fluid and synovium during acute illness were unsuccessful.Although echoviruses are recognized producers of a wide spectrum of human illness, arthritis is generally not considered part of this spectrum (1-3), or at most is an exceedingly rare occurrence in echovirus infections (43). Only one weakly documented case of acute arthritis attributed to echovirus is reported in the English language literature (4). A second case documented by viral isolation is reported here and presents the hitherto undescribed synovial fluid and synovial histologic findings. CASE REPORTA 35-year-old female bookkeeper was admitted to the Hospital of the University of Pennsylvania on July 18, 1970 with complaints of fever and myalgias. On July 15, the patient awoke with a painful right shoulder. By evening, chills, fever, and myalgias had developed coincident with marked neck stiffness and pain in both shoulders and the right arm. The shoulders, elbows, ankles, and right metatarsophalangeal (MTP) joints became painful with conspicuous swelling of the knees, ankles, and right MTP joints. The patient was prescribed phenylbutazone by her local physician but noted no symptomatic relief. She denied cough, coryza, sore throat, conjunctivitis, alopecia, mouth ulcers, jaundice, pruritis, Raynaud's phenomenon, nausea, vomiting, abdominal discomfort, or vaginal discharge. The day prior to admission, she noted three small evanescent erythematous skin lesions on her arms. There was no past or family history of rheumatic fever or joint disease. The patient denied recent immunizations or exposure to jaundiced or otherwise ill persons.On admission, she was alert but in obvious distress from painful joints and was unable to walk. Her oral temperature was 39°C (102°F). N o skin eruptions or adenopathy were noted. There was conspicious nuchal rigidity with painful limitation of neck motion. The mandible was tender with painful temporomandibular joint limitation of motion. Diminished right shoulder range of motion without effusion was present. Erythema and tenderness over the left ulnar styloid without wrist effusion were noted. Bilateral non-erythematous relatively non-tender knee effusions were evident, The medial aspect of the left ankle was erythematous, swollen, and tender. The right ankle was tender and swollen with limitation of motion, but was not erythematous. The right first, second, and third MTP joints were hot, erythematous, swollen, and exquisitely tender. No tenosynovitis was present.Laboratory studies revealed a hematocrit of 37 and a leukocyte count of 13,600/mmS with 81% neutrophils and 19%

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“…Toplum için önemli bir sorun olan Hepatit B virüsünün reaktif artritlere sebep olabileceği son yıllar-da yapılan çalışmalarda ileri sürülmüştür (2,17,18,19). Yapılan bazı çalışmalarda etyolojik faktör olarak hiçbir ajan tesbit edilemeyen reaktif artritli hastalarda HBsAg'i pozitif bulunmuş ve etyolojik ajan olarak hepatit B virüsü suçlanmıştır (9,19).…”

Section: Discussionunclassified

“…Yapılan bazı çalışmalarda etyolojik faktör olarak hiçbir ajan tesbit edilemeyen reaktif artritli hastalarda HBsAg'i pozitif bulunmuş ve etyolojik ajan olarak hepatit B virüsü suçlanmıştır (9,19). Duffy ve arkadaşları ise B hepatit tanısı alan 39 hastanın 28'inde hastalıktan 2-4 hafta sonra reaktif artrit geliştiğini tesbit etmişlerdir (19). Bizim çalışmamızda 78 reaktif artritli hastanın 11'inde yani %14.02' sinde HBsAg'i pozitif bulunmuştur.…”

Section: Discussionunclassified

REAKTİF ARTRİTLERDE HBsAg, AntiHBs, Anti-HCV, CMV-lgM VE CMV-lgG PREVALANSI

Hadi;TURGAY¹

1997

Ankara Üniversitesi Tıp Fakültesi Mecmuası

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Polyarthritis, Polyarteritis and Hepatitis B

Cited by 186 publications

References 0 publications

In vitro antigen-induced antibody responses to hepatitis B surface antigen in man. Kinetic and cellular requirements.

In vitro antigen-induced antibody responses to hepatitis B surface antigen in man. Kinetic and cellular requirements.

Echovirus‐associated polyarthritis. report of a case with synovial fluid and synovial histologic characterization

REAKTİF ARTRİTLERDE HBsAg, AntiHBs, Anti-HCV, CMV-lgM VE CMV-lgG PREVALANSI

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