Polyarteritis nodosa in infancy

Polyarteritis nodosa in childhood

“…Numerous investigators have noted that the arteritis of MCLS is both macroscopically and microscopically identical to that seen in infantile polyarteritis nodosa (1-3,15,17,18). Even among survivors of MCLS, coronary angiography has revealed coronary artery aneurysms (19)(20)(21) like those commonly seen in IPN (6,9,10,22).…”

“…Keith and Baggenstoss ( 5 ) estimated that the diagnosis was made prior to death in only 15% of 44 cases reviewed through 1941. Among 20 infants less than 2 years of age reported in 1963, Roberts and Fetterman (6) found that PAN was considered in only 2 cases prior to autopsy. Only 26 cases in infancy were reported through 1973 (7) and less than 150 cases in older children were identified by Reimold et a1 (8) through 1976.…”

History of the worldwide emergence of Kawasaki disease

“…9 Although KD was emerging as a new clinical entity in Japan after World War II, case reports from all over the Western world in the early part of the 20th century clearly described a fatal condition of infants termed infantile periarteritis nodosa (IPN). 10,11 This uniformly fatal vasculitis was deemed pathologically indistinguishable from fatal KD by Landing and Larson in their landmark review of KD and IPN autopsies. 12 If one accepts the concept that IPN is simply the fatal form of KD, then case reports and series were reported throughout Western Europe and North and South America beginning in the 1930s.…”

Periarteritis Nodosa in Infancy

“…[1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] All have had similar clinical findings. A premortem diagnosis of periarteritis nodosa is rare, documented only once in the cases reviewed.20 An awareness of the signs and symptoms of this disease, however, may make a presumptive diagnosis possible during life with consequent initiation of proper treatment.…”