Polyanions and their complexes II. Light-induced paramagnetism in solid glycosaminoglycan-dye complexes

Balazs, Endre A.; Phillips, Glyn O.; Young, M.G.

doi:10.1016/0304-4165(67)90113-4

Cited by 11 publications

(3 citation statements)

References 12 publications

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“…HA radicals, generated by UV irradiation, were identified by ESR spectroscopy. ,, The results were in agreement with the ESR spectra, observed for HA degradation induced by hydroxyl radicals …”

Section: 3 Degradation By Free Radicalssupporting

confidence: 85%

“…203 HA radicals, generated by UV irradiation, were identified by ESR spectroscopy. 142,201,204 The results were in agreement with the ESR spectra, observed for HA degradation induced by hydroxyl radicals. 179 As explained in section 2.1.2, oxidative degradation of HA can be caused by periodic acid, 43,186,205 due to destruction of the C-2 and C-3 glycol groups present in HA (Figure 2).…”

Section: Degradation By Free Radicalssupporting

confidence: 83%

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Hyaluronan: Preparation, Structure, Properties, and Applications

Lapčík

Smedt²,

Demeester³

et al. 1998

Chem. Rev.

659

313

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under Prof. S. Claesson. Holding 24 industrial patents and author of more than 120 publications, he has lectured at several European universities. His current interest is in the photochemistry and physical chemistry of polymers. He is a member of the Czech Chemical Society. Stefaan De Smedt was born in Geraardsbergen, Belgium, in 1967. He studied pharmacy at the University of Ghent, Belgium, and received his M.S. degree in pharmaceutical sciences in 1990. As a scholar of the Belgian Institute for the Encouragement of Scientific Research in Industry and Agriculture, he enrolled in a Ph.D. program at the University of Ghent, under the direction of Prof. J. Demeester. He studied rheology at the Catholic University of Leuven. He received the Scott Blair Biorheology Award in 1993−1995 for his work on the structural characterization of hyaluronan solutions. To study diffusion phenomena in polymer solutions, he collaborated with Prof. Y. Engelborghs at the Laboratory of Biomolecular Dynamics of the Catholic University of Leuven. In 1995, he joined the pharmaceutical development group of Janssen Research Foundation. Since 1997 he has been a postdoctoral fellow of F.W.O.-Vlaanderen at the Laboratory of General Biochemistry and Physical Pharmacy of the University of Ghent. He is a member of the Controlled Release Society, the European Federation for Pharmaceutical Sciences, the Belgian Society for Pharmaceutical Sciences, the European Society of Rheology, the Belgian Biophysical Society, and the Polymer Networks Group. He is a consultant to the Journal of Controlled Release and to Pharmaceutical Research. His current research interests include the mobility and interactions of macromolecular drugs in pharmaceutical polymer matrixes and biological polymer systems.

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Section: 3 Degradation By Free Radicalssupporting

confidence: 85%

Section: Degradation By Free Radicalssupporting

confidence: 83%

Hyaluronan: Preparation, Structure, Properties, and Applications

Lapčík

Smedt²,

Demeester³

et al. 1998

Chem. Rev.

659

313

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“…Hydrodynamic lubrication of human joints depends on the synovial fluid secreted from the synovium cells (synoviocytes). The synovium fluid is a dialysate of blood plasma that is devoid of clotting factors, erythrocytes, and hemoglobin, and contains proteoglycans, glycoproteins (e.g., hyaluronate and lubricin), and phospholipids 42–45. A dependence of the apparent viscosity of synovial fluid on shear rate and concentration of hyaluronan has been observed in previous studies 46–48…”

Section: Molecular Basis Of Synovial Joint Lubricationmentioning

confidence: 77%

The Interface of Functional Biotribology and Regenerative Medicine in Synovial Joints

Neu

Komvopoulos

Reddi

2008

Tissue Engineering Part B: Reviews

124

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Biotribology is the science of biological surfaces in sliding contact encompassing the concepts of friction, wear, and lubrication of interacting surfaces. This bioscience field has emerged from the classical field of tribology and is of paramount importance to the normal function of numerous tissues, including articular cartilage, blood vessels, heart, tendons, ligaments, and skin. Surprisingly, relatively little attention has been given to the restoration of surface characteristics in the fields of tissue engineering and regenerative medicine—the science of design and manufacture of new tissues for the functional restoration of impaired or diseased organs that depend on inductive signals, responding stem cells, and extracellular matrix scaffolding. Analogous to ancient civilizations (c. 3000 B.C.) that introduced wheeled vehicles, sledges for transporting heavy blocks, and lubricants, modern biotribologists must aim to restore surface characteristics to regenerated tissues and develop novel biomaterials with optimal tribological properties. The objective of this article is to highlight the significance of functional biotribology in the physiology of body surfaces and provide a comprehensive overview of unresolved issues and controversies as it relates to regenerative medicine. Specific attention is placed on the molecular basis of lubrication, mechanical and biochemical regulation of lubricating molecules, and the need to study wear processes in articular cartilage, especially in light of degenerative diseases, such as osteoarthritis. Surface engineering of replacement tissues exhibiting low friction and high wear resistance is examined using articular cartilage as an illustrative model system.

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Photodegradation of hyaluronic acid: EPR and size exclusion chromatography study

Lapčík

Chabrecek

Staško³

1991

Biopolymers

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Photochemically induced radical reactions involving the lateral sequences and the end macromolecular chain groups of hyaluronic acid in aqueous solutions at 293K were studied by EPR spin trapping technique with DMPO (5,5-dimethylpyrroline-1-oxide). In the first 1-10 minutes of irradiation EPR indicates spin adducts of two carbon centered radicals with the splitting constants of aN = 1.60 mT, aH = 2.51 mT and aN = 1.56 mT, aH = 2.28 mT. After longer irradiation time (over 10 minutes) dominate two further DMPO adducts of radicals centered on hetero-atoms with splitting constants of aN = 1.44 mT, aH = 1.60 mT and of aN = 1.49 mT, aH = 1.49 mT. Simultaneously, molecular weight followed by SEC decreases, suggesting that UV irradiation leads to the breaking of interglycosidic bonds of hyaluronic acid main macromolecular chain.

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Polyanions and their complexes II. Light-induced paramagnetism in solid glycosaminoglycan-dye complexes

Cited by 11 publications

References 12 publications

Hyaluronan: Preparation, Structure, Properties, and Applications

Hyaluronan: Preparation, Structure, Properties, and Applications

The Interface of Functional Biotribology and Regenerative Medicine in Synovial Joints

Photodegradation of hyaluronic acid: EPR and size exclusion chromatography study

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