Polyaniline Functionalized Peptide Self-Assembled Conductive Hydrogel for 3D Cell Culture

Abstract

The functionalization of self-assembled peptide hydrogel is of great importance to broaden its applications in the field of biomedicine. In this work, conductive hydrogel is fabricated by introducing conductive polymer polyaniline into peptide self-assembled hydrogel. Compared with pure peptide formed hydrogel, the conductive hydrogel exhibits enhanced conductivity, mechanical property and stability. In addition, the hydrogel is tested to be of great injectability and 3D bio-printability and could support the viability of encapsulated cells that are sensitive to electrical signals. It should have great application prospects in the preparation of tissue engineering scaffolds.

Peptide‐Based Optical/Electronic Materials: Assembly and Recent Applications in Biomedicine, Sensing, and Energy Storage

“…Through 3D bioprinting technique, biomimetic cell culture scaffold could be obtained, which could support the 3D proliferation of cells especially those that are sensitive to electrical signals. [ 96 ]…”

Self-Assembled Peptide Hydrogels in Regenerative Medicine

“…It has roles in cell attachment and migration and the ability to promote cell-cell interactions, cell proliferation, and cell division [10,11]. Therefore, it can improve biocompatibility and control the biodegradation of drugs [12]. Some organic small molecules can be at very low concentrations (mass fraction < 1%) in the water through the molecular self-assembly process to form a supramolecular network structure that will be wrapped in the water to form a non-flowing colloidal Gels 2023, 9, 653 2 of 17 structure called a hydrogel [13].…”