Polyanhydrides

Kumar, Neeraj; Albertsson, Ann‐Christine; Edlund, Ulrica; Teomim, Doron; Rasiel, Aliza; Domb, Abraham J.

doi:10.1002/3527600035.bpol4007

Cited by 3 publications

(3 citation statements)

References 86 publications

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“…Polyanhydrides are an important class of hydrolytically degrading biomaterials used for controlled release applications. − Their characteristic surface erosion behavior (due to their hydrophobic nature) makes them excellent candidates for controlled delivery of drugs and biomacromolecules, such as therapeutic proteins, vaccines, and growth factors. However, polyanhydrides have a few limitations, such as poor processability, low solubility in common solvents, and a tendency to be very hydrophobic. ,, Another complicating factor arises because polyanhydrides are usually synthesized by melt polycondensation at elevated temperatures under vacuum, making the synthesis cumbersome and slow. − Moreover, choosing a polymer chemistry that can effectively stabilize a given therapeutic is not trivial and is further complicated by the large parameter space.…”

Section: Introductionmentioning

confidence: 99%

“…Polyanhydrides are an important class of hydrolytically degrading biomaterials used for controlled release applications. [1][2][3][4][5][6][7] Their characteristic surface erosion behavior (due to their hydrophobic nature) makes them excellent candidates for controlled delivery of drugs and biomacromolecules, such as therapeutic proteins, vaccines, and growth factors. However, polyanhydrides have a few limitations, such as poor processability, low solubility in common solvents, and a tendency to be very hydrophobic.…”

Section: Introductionmentioning

confidence: 99%

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Parallel Synthesis and High Throughput Dissolution Testing of Biodegradable Polyanhydride Copolymers

et al. 2005

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We have demonstrated that polycondensation reactions can be carried out in a combinatorial fashion and that the polymer library can be screened at high throughput using a rapid prototyping technique to fabricate multiwell substrates. A linearly varying compositional library of 100 different biodegradable polyanhydride random copolymers that are promising carriers for controlled drug delivery was designed, fabricated, and characterized by IR microscopy within a few hours. The polyanhydride copolymer library was based on 1,6-bis(p-carboxyphenoxy)hexane (CPH) and sebacic anhydride (SA) and was characterized with infrared microspectroscopy to determine the composition within each well. Since degradation and release rates depend on copolymer composition, we also developed new high-throughput methods to investigate drug release from this library of copolymers by designing specific wells for each task. A subset of this library was chosen, and a substrate was designed and fabricated to enable the synthesis and monitoring of dye dissolution from a range of polyanhydride copolymers in a parallel fashion using a CCD camera. Multisample substrates were fabricated with a novel rapid prototyping method that consists of an organic solvent-resistant array of 10 x 10 microwells of 2-Î¼L volume each. The libraries were deposited with a custom-built liquid dispensing system consisting of a series of computer-controlled volume-dispensing pumps and XYZ motion stages. The parallel dye dissolution study displayed a decreasing rate of release with increasing CPH content. This result agrees with previously published data for dye release from poly(CPH-co-SA) copolymers. The methodology described in this work is amenable to numerous applications in the arenas of high-throughput polymer synthesis and characterization. We have demonstrated that polycondensation reactions can be carried out in a combinatorial fashion and that the polymer library can be screened at high throughput using a rapid prototyping technique to fabricate multiwell substrates. A linearly varying compositional library of 100 different biodegradable polyanhydride random copolymers that are promising carriers for controlled drug delivery was designed, fabricated, and characterized by IR microscopy within a few hours. The polyanhydride copolymer library was based on 1,6-bis(p-carboxyphenoxy)hexane (CPH) and sebacic anhydride (SA) and was characterized with infrared microspectroscopy to determine the composition within each well. Since degradation and release rates depend on copolymer composition, we also developed new high-throughput methods to investigate drug release from this library of copolymers by designing specific wells for each task. A subset of this library was chosen, and a substrate was designed and fabricated to enable the synthesis and monitoring of dye dissolution from a range of polyanhydride copolymers in a parallel fashion using a CCD camera. Multisample substrates were fabricated with a novel rapid prototyping method that consists of an organic s...

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Parallel Synthesis and High Throughput Dissolution Testing of Biodegradable Polyanhydride Copolymers

et al. 2005

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“…[1][2][3][4][5][6][7] The conventional method of synthesizing polyanhydrides is by melt polycondensation of acetylated dicarboxylic acid prepolymer (Scheme 1). [6,[8][9][10][11][12][13] This method affords high-molecular-weight polymer with good yields but it takes 1.5 to 3 h to conduct the polymerization.…”

Section: Introductionmentioning

confidence: 99%

Rapid Synthesis of Polyanhydrides by Microwave Polymerization

Vogel

Mallapragada

Narasimhan

2003

Macromol. Rapid Commun.

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Summary: Polyanhydrides were synthesized from aliphatic and aromatic diacids using microwave radiation without vacuum at significantly reduced reaction times when compared to conventional melt polycondensation. Reaction conditions, such as duration of polymerization, equivalents of acetic anhydride, and choice of starting species, were studied. In addition, copolymers were synthesized and monomer sequence lengths were calculated using dyad conditional probabilities. The results are in good agreement with monomer sequence lengths from conventional copolymerization.Comparison of the monomer sequence lengths in poly(CPH‐co‐SA) synthesized both conventionally and by microwave heating.magnified imageComparison of the monomer sequence lengths in poly(CPH‐co‐SA) synthesized both conventionally and by microwave heating.

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Biodegradation of Polyanhydrides

et al. 2002

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Introduction Degradation: A Real Meaning Mechanisms Involved in Degradation Historical Outline Polymer Erosion Changes in Polymer Structure During Erosion Factors Affecting Degradation Synthesis Structures Surface Analysis Polyanhydride Degradation: In‐vitro and In‐vivo Approaches In‐vitro Degradation and Drug Release In‐vivo Degradation and Drug Release Modeling of Polymer Erosion Production of Polyanhydrides World Market Applications Patents Outlook and Perspectives

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Polyanhydrides

Abstract: Introduction Historical Outline Synthesis Polyanhydride Structures Unsaturated Polymers Aliphatic‐aromatic Homopolymers Soluble Aromatic Copolymers Poly(ester‐anhydrides) Fatty Acid‐based Polyanhydrides … Show more

Cited by 3 publications

References 86 publications

Parallel Synthesis and High Throughput Dissolution Testing of Biodegradable Polyanhydride Copolymers

Parallel Synthesis and High Throughput Dissolution Testing of Biodegradable Polyanhydride Copolymers

Rapid Synthesis of Polyanhydrides by Microwave Polymerization

Biodegradation of Polyanhydrides

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