Polyamines in macroalgae: advances and future perspectives

Schweikert, Katja; Burritt, David J.

doi:10.1111/jpy.12325

Cited by 12 publications

(7 citation statements)

References 139 publications

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“…However, despite intensive research, their role and mechanism of action in algae and higher plants are still poorly understood. Modulation of their levels influences growth, cell division, metabolite profiles, transcriptome patterns, responses to stressors (e.g., salinity and oxidative stress), and other physiological functions [21,[47][48][49][50][51][52][53][54][55][56][57][58]. In synchronized C. reinhardtii cultures, transition to the cell division phase was preceded by a 4-fold increase in ornithine decarboxylase activity and a 10-fold increase in putrescine level.…”

Section: Discussionmentioning

confidence: 99%

Metabolic Flexibility Underpins Growth Capabilities of the Fastest Growing Alga

et al. 2017

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The factors rate-limiting growth of photosynthetic organisms under optimal conditions are controversial [1-8]. Adaptation to extreme environments is usually accompanied by reduced performance under optimal conditions [9, 10]. However, the green alga Chlorella ohadii, isolated from a harsh desert biological soil crust [11-17], does not obey this rule. In addition to resistance to photodamage [17, 18], it performs the fastest growth ever reported for photosynthetic eukaryotes. A multiphasic growth pattern (very fast growth [phase I], followed by growth retardation [phase II] and additional fast growth [phase III]) observed under constant illumination and temperature indicates synchronization of the algal population. Large physiological changes at transitions between growth phases suggest metabolic shifts. Indeed, metabolome analyses at points along the growth phases revealed large changes in the levels of many metabolites during growth with an overall rise during phase I and decline in phase II. Multivariate analysis of the metabolome data highlighted growth phase as the main factor contributing to observed metabolite variance. The analyses identified putrescine as the strongest predictive metabolite for growth phase and a putative growth regulator. Indeed, extracellular additions of polyamines strongly affected the growth rate in phase I and the growth arrest in phase II, with a marked effect on O exchange. Our data implicate polyamines as the signals harmonizing metabolic shifts and suggest that metabolic flexibility enables the immense growth capabilities of C. ohadii. The data provide a new dimension to current models focusing on growth-limiting processes in photosynthetic organisms where the anabolic and catabolic metabolisms must be strictly regulated.

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Section: Discussionmentioning

confidence: 99%

Metabolic Flexibility Underpins Growth Capabilities of the Fastest Growing Alga

et al. 2017

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“…Selected reviews focus on the essential roles of polyamines, polyamines in secondary metabolism as well as polyamine alkaloids and conjugates. 807–824…”

Section: The Isolation Of Water-soluble Natural Productsmentioning

confidence: 99%

The isolation of water-soluble natural products – challenges, strategies and perspectives

et al. 2022

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“…Numerous studies in plants and macroalgae have shown that polyamines play important roles in protecting against abiotic stresses [10,145,146,147,148,149]. Like many autotroph organisms, microalgae must to cope with environmental stress in nature, such as a lack of nutrients, temperature fluctuations, and excessive light.…”

Section: The Physiological Roles Of Polyamines In Microalgaementioning

confidence: 99%

Polyamines in Microalgae: Something Borrowed, Something New

Lin

2018

Marine Drugs

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Microalgae of different evolutionary origins are typically found in rivers, lakes, and oceans, providing more than 45% of global primary production. They provide not only a food source for animals, but also affect microbial ecosystems through symbioses with microorganisms or secretion of some metabolites. Derived from amino acids, polyamines are present in almost all types of organisms, where they play important roles in maintaining physiological functions or against stress. Microalgae can produce a variety of distinct polyamines, and the polyamine content is important to meet the physiological needs of microalgae and may also affect other species in the environment. In addition, some polyamines produced by microalgae have medical or nanotechnological applications. Previous studies on several types of microalgae have indicated that the putative polyamine metabolic pathways may be as complicated as the genomes of these organisms, which contain genes originating from plants, animals, and even bacteria. There are also several novel polyamine synthetic routes in microalgae. Understanding the nature of polyamines in microalgae will not only improve our knowledge of microalgal physiology and ecological function, but also provide valuable information for biotechnological applications.

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Polyamines in macroalgae: advances and future perspectives

Cited by 12 publications

References 139 publications

Metabolic Flexibility Underpins Growth Capabilities of the Fastest Growing Alga

Metabolic Flexibility Underpins Growth Capabilities of the Fastest Growing Alga

The isolation of water-soluble natural products – challenges, strategies and perspectives

Polyamines in Microalgae: Something Borrowed, Something New

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