Polyamines are involved in murine kidney development controlling expression of c-ret, E-cadherin, and Pax2/8 genes

Loikkanen, Ildikó; Lin, Yanfeng; Railo, Antti; Pajunen, Antti; Vainio, Seppo

doi:10.1111/j.1432-0436.2005.00036.x

Cited by 6 publications

(14 citation statements)

References 50 publications

(51 reference statements)

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“…6 and 7). In line with our observation, inhibition of ODC1, the rate-limiting enzyme for polyamine synthesis, has been shown previously to reduce cell proliferation and tubule formation in murine kidney explants at E11.0 (27). The exact mechanism how polyamines influence kidney development is unknown but may involve the regulation of genes acting on the mesenchymalepithelial balance (27).…”

Section: Discussionsupporting

confidence: 89%

“…Recent findings indicate that polyamines are involved in normal kidney development (27). Nephrogenesis is accomplished by the reciprocal interaction between two tissues: the epithelial ureteric bud, which is formed from the nephric duct, and the surrounding metanephric mesenchyme (28).…”

mentioning

confidence: 99%

“…Interestingly, ODC1 inhibition in ex vivo cultured murine embryonic kidneys resulted in a smaller organ size, fewer epithelial ureteric bud branches, and delayed tubule formation (27). These dysmorphologies were associated with reduced cell proliferation and alteration in mesenchymal gene expression, suggesting that polyamines are important for normal murine kidney development (27).…”

mentioning

confidence: 99%

“…These dysmorphologies were associated with reduced cell proliferation and alteration in mesenchymal gene expression, suggesting that polyamines are important for normal murine kidney development (27). ODC1 expression is controlled on the molecular level by the transcription factor WT1, which can either repress or activate the proximal ODC1 promoter depending on the cellular context (29).…”

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confidence: 99%

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Amine Oxidase Copper-containing 1 (AOC1) Is a Downstream Target Gene of the Wilms Tumor Protein, WT1, during Kidney Development

Kirschner

Braun

Jacobi

et al. 2014

Journal of Biological Chemistry

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Background: Polyamines and their diamine precursor putrescine are ubiquitous organic polycations involved in cell growth and proliferation. Results: The Wilms tumor suppressor, WT1, stimulates transcription of the AOC1 gene, which encodes the key enzyme for putrescine breakdown. Conclusion: WT1-dependent regulation of putrescine degradation, mediated by AOC1, has a role in kidney morphogenesis. Significance: The findings provide novel insights into transcriptional mechanisms controlling genitourinary development.

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Section: Discussionsupporting

confidence: 89%

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confidence: 99%

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confidence: 99%

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confidence: 99%

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Amine Oxidase Copper-containing 1 (AOC1) Is a Downstream Target Gene of the Wilms Tumor Protein, WT1, during Kidney Development

Kirschner

Braun

Jacobi

et al. 2014

Journal of Biological Chemistry

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“…43 Polyamines have been implicated in keratinocyte differentiation, kidney organogenesis and neuronal differentiation. 44,45 Given the requirement for their enzyme regulators during development, polyamines at different ratios likely play a significant role in directing differentiation to all lineages.…”

Section: Methodsmentioning

confidence: 99%

A role for polyamine regulators in ESC self-renewal

Zhao

Goh

et al. 2012

Cell Cycle

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E mbryonic stem cells (ESCs) dependon extensive regulatory networks to coordinate their self-renewal and differentiation. The polyamine pathway regulator AMD1 was recently implicated in ESC self-renewal and directed differentiation of ESCs to neural precursor cells (NPCs). The polyamines spermine and spermidine are essential for a wide range of biological processes, and their levels are tightly regulated. Here, we review the polyamine pathway and discuss how it can impact polyamine levels, cellular methylation and hypusinated EIF5A levels. We discuss how it could feed into regulation of ESC self-renewal and directed differentiation. We show that in addition to AMD1, a second rate-limiting enzyme in the polyamine pathway, ODC1, can also promote ESC self-renewal, and that both Amd1 and Odc1 can partially substitute for Myc during cellular reprogramming. We propose that both Amd1 and Odc1 are essential regulators of ESCs and function to ensure high polyamine levels to promote ESC self-renewal.

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TRPC1‐ and TRPC3‐dependent Ca²⁺ signaling in mouse cortical astrocytes affects injury‐evoked astrogliosis in vivo

Belkacemi¹,

Niermann²,

Hofmann³

et al. 2017

Glia

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Following brain injury astrocytes change into a reactive state, proliferate and grow into the site of lesion, a process called astrogliosis, initiated and regulated by changes in cytoplasmic Ca2+. Transient receptor potential canonical (TRPC) channels may contribute to Ca2+ influx but their presence and possible function in astrocytes is not known. By RT-PCR and RNA sequencing we identified transcripts of Trpc1, Trpc2, Trpc3 and Trpc4 in FACS-sorted glutamate aspartate transporter (GLAST)-positive cultured mouse cortical astrocytes and subcloned full-length Trpc1 and Trpc3 cDNAs from these cells. Ca2+ entry in cortical astrocytes depended on TRPC3 and was increased in the absence of Trpc1. After co-expression of Trpc1 and Trpc3 in HEK-293 cells both proteins co-immunoprecipitate and form functional heteromeric channels, with TRPC1 reducing TRPC3 activity. In vitro, lack of Trpc3 reduced astrocyte proliferation and migration whereas the TRPC3 gain-of-function moonwalker mutation and Trpc1 deficiency increased astrocyte migration. In vivo, astrogliosis and cortex edema following stab wound injury were reduced in Trpc3−/− but increased in Trpc1−/− mice. In summary, our results show a decisive contribution of TRPC3 to astrocyte Ca2+ signaling, which is even augmented in the absence of Trpc1, in particular following brain injury. Targeted therapies to reduce TRPC3 channel activity in astrocytes might therefore be beneficial in traumatic brain injury.

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Polyamines are involved in murine kidney development controlling expression of c-ret, E-cadherin, and Pax2/8 genes

Cited by 6 publications

References 50 publications

Amine Oxidase Copper-containing 1 (AOC1) Is a Downstream Target Gene of the Wilms Tumor Protein, WT1, during Kidney Development

Amine Oxidase Copper-containing 1 (AOC1) Is a Downstream Target Gene of the Wilms Tumor Protein, WT1, during Kidney Development

A role for polyamine regulators in ESC self-renewal

TRPC1‐ and TRPC3‐dependent Ca²⁺ signaling in mouse cortical astrocytes affects injury‐evoked astrogliosis in vivo

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Polyamines are involved in murine kidney development controlling expression of c-ret, E-cadherin, and Pax2/8 genes

Cited by 6 publications

References 50 publications

Amine Oxidase Copper-containing 1 (AOC1) Is a Downstream Target Gene of the Wilms Tumor Protein, WT1, during Kidney Development

Amine Oxidase Copper-containing 1 (AOC1) Is a Downstream Target Gene of the Wilms Tumor Protein, WT1, during Kidney Development

A role for polyamine regulators in ESC self-renewal

TRPC1‐ and TRPC3‐dependent Ca2+ signaling in mouse cortical astrocytes affects injury‐evoked astrogliosis in vivo

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Product

Resources

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TRPC1‐ and TRPC3‐dependent Ca²⁺ signaling in mouse cortical astrocytes affects injury‐evoked astrogliosis in vivo