Polyamides in solution. III. Viscometry of linear polycaprolactam

Mattiussi, A.; Gechele, G.B.; Francesconi, Romolo

doi:10.1002/pol.1969.160070212

Cited by 39 publications

(13 citation statements)

References 13 publications

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“…APS pre-polymers were insoluble in common organic solvents such as dicholoromethane, acetone and ethanol. However, both APS pre-polymers were soluble in HFIP, a common solvent used for dissolving polyamides [21]. The presence of esters, carboxylic acids, secondary amides, and primary amines was determined from FT-IR data (see Supplementary Table 1; Supplementary Fig.…”

Section: Resultsmentioning

confidence: 99%

“…See Section 2 for details on synthesis. The MarkeHouwink coefficients for APS pre-polymers in HFIP at 30 C were interpolated from polyamides in HFIP [21] to be K m ¼ 5.6 Â 10 À4 dL/g and a ¼ 0.746. The polymers were assumed to be low-molecular weight oligomers a priori, which would reduce the probability of branching and therefore ensure the validity of the selected MarkeHouwink coefficients.…”

Section: Characterization Of 13-diamino-2-hydroxy-propane-based Aps mentioning

confidence: 99%

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Amino alcohol-based degradable poly(ester amide) elastomers

et al. 2008

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Currently available synthetic biodegradable elastomers are primarily composed of crosslinked aliphatic polyesters, which suffer from deficiencies including (1) high crosslink densities, which results in exceedingly high stiffness, (2) rapid degradation upon implantation, or (3) limited chemical moieties for chemical modification. Herein, we have developed poly(1,3-diamino-2-hydroxypropane-co-polyol sebacate)s, a new class of synthetic, biodegradable elastomeric poly(ester amide)s composed of crosslinked networks based on an amino alcohol. These crosslinked networks feature tensile Young's modulus on the order of 1MPa and reversable elongations up to 92%. These polymers exhibit in vitro and in vivo biocompatibility. These polymers have projected degradation half-lives up to 20 months in vivo.

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Section: Resultsmentioning

confidence: 99%

Section: Characterization Of 13-diamino-2-hydroxy-propane-based Aps mentioning

confidence: 99%

Amino alcohol-based degradable poly(ester amide) elastomers

et al. 2008

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“…The double extrapolation plots of reduced and inherent viscosity versus concentration are plotted by calculating the corresponding reduced viscosity and inherent viscosity. The molecular weight of the polyamide was calculated from the Mark–Houwink equation: [ η ] = 5.36 × 10 −4 × (M wv ) 0.75 (Mattiussi et al ., ; Aharoni et al ., ). The calculated value of M wv was 22.5 ± 1 kDa.…”

Section: Methodsmentioning

confidence: 99%

A simple approach to prepare molecularly imprinted polymers from nylon‐6

Dmitrienko

Bulushev

Haupt

et al. 2013

J of Molecular Recognition

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A convenient and simple approach for the preparation of molecularly imprinted polymers (MIPs) based on polyamide (nylon-6) was developed. The polymer matrix formation occurred during the transition of nylon from dissolved to solid state in the presence of template molecules in the initial solution. 2,2,2-Trifluoroethanol (TFE) was chosen as a main solvent for the polyamide. It provides a high solubility of nylon and does not significantly change the structure of biopolymers. The alteration of the polymer matrix structure after the addition of different types of porogens in the nylon/TFE solution was investigated. The structured polymers in the form of films and microparticles were prepared in the chosen optimal conditions. Different model biomolecular templates (of low- and high-molecular weight) were used for the preparation of MIPs, which were shown to specifically recognize these molecules upon binding experiments. The binding of the template molecules to MIPs was monitored using spectrophotometric, radioisotopic, or fluorometric detection. The selectivity coefficients of the MIPs were estimated to be 1.4-4.6 depending on the type of templates and conditions of the polymer matrix formation.

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“…The Mark–Houwink coefficients for APS prepolymers in HFIP at 30°C were interpolated from polyamides in HFIP12 to be K m = 5.6 × 10 −4 dL g −1 and a = 0.746. The polymers were assumed to be low‐molecular‐weight oligomers a priori , which would reduce the probability of branching and therefore ensure the validity of the selected Mark–Houwink coefficients.…”

Section: Methodsmentioning

confidence: 99%

In vitro and in vivo degradation of poly(1,3‐diamino‐2‐hydroxypropane‐co‐polyol sebacate) elastomers

Bettinger

Bruggeman

Borenstein

et al. 2008

J Biomedical Materials Res

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Biomaterials with a wide range of tunable properties are desirable for application-specific purposes. We have previously developed a class of elastomeric poly(ester amides) based on the amine alcohol 1,3-diamino-2-hydroxypropane termed poly(1,3-diamino-2-hydroxypropane-co-polyol sebacate) or APS. In this work, we have synthesized and characterized formulations of APS polymers and studied the degradation of these polymers in vitro and in vivo. It was found that the chemical, physical, and mechanical properties of APS polymers could be tuned by adjusting monomer feed ratios and polymerization conditions. The degradation kinetics could also be greatly influenced by altering the formulation of APS polymers. In vivo degradation half-lives ranged from 6 to approximately 100 weeks. Furthermore, the dominant degradation mechanism (i.e. hydrolytic or enzymatic) could be controlled by adjusting the specific formulation of the APS polymer. On the basis of the observed in vitro and in vivo biodegradation phenomena, we also propose that the primary modes of degradation are composition dependent.

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Polyamides in solution. III. Viscometry of linear polycaprolactam

Cited by 39 publications

References 13 publications

Amino alcohol-based degradable poly(ester amide) elastomers

Amino alcohol-based degradable poly(ester amide) elastomers

A simple approach to prepare molecularly imprinted polymers from nylon‐6

In vitro and in vivo degradation of poly(1,3‐diamino‐2‐hydroxypropane‐co‐polyol sebacate) elastomers

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