Polyamide Backbone Modified Cell Targeting and Penetrating Peptides in Cancer Detection and Treatment

Shah, Sunil; Casanova, Nelson; Antuono, Gina; Sabatino, David A.

doi:10.3389/fchem.2020.00218

Cited by 6 publications

(5 citation statements)

References 115 publications

(139 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Modifications of peptide backbones have been used in a wide range of fields, including HIV protease inhibitors and receptor mediators (Pu et al 2019 ; von Recum and Pokorski 2013 ). The backbone can also trigger profound changes in molecular chirality, hybridization, conformation, and the self-assembly of peptide structures and nanoparticles (Shah et al 2020 ).…”

Section: Strategies To Overcome the Limitationsmentioning

confidence: 99%

“…While administering drugs via nasal route, also known as snorting, drugs are insufflated through the nose. Drugs that are administered through the nasal cavity enter the olfactory mucosa which carries the drugs directly to the cerebrospinal fluid and brain through the olfactory receptor neurons (Shah et al 2020 ). Numerous drugs are marketed such as LHRH, 8-arginine vasopressin (ADH), etc.…”

Section: Peptide-based Drug Deliverymentioning

confidence: 99%

See 1 more Smart Citation

Strategic Approaches to Improvise Peptide Drugs as Next Generation Therapeutics

Barman

Joshi

Sharma

et al. 2023

Int J Pept Res Ther

View full text Add to dashboard Cite

In recent years, the occurrence of a wide variety of drug-resistant diseases has led to an increase in interest in alternate therapies. Peptide-based drugs as an alternate therapy hold researchers’ attention in various therapeutic fields such as neurology, dermatology, oncology, metabolic diseases, etc. Previously, they had been overlooked by pharmaceutical companies due to certain limitations such as proteolytic degradation, poor membrane permeability, low oral bioavailability, shorter half-life, and poor target specificity. Over the last two decades, these limitations have been countered by introducing various modification strategies such as backbone and side-chain modifications, amino acid substitution, etc. which improve their functionality. This has led to a substantial interest of researchers and pharmaceutical companies, moving the next generation of these therapeutics from fundamental research to the market. Various chemical and computational approaches are aiding the production of more stable and long-lasting peptides guiding the formulation of novel and advanced therapeutic agents. However, there is not a single article that talks about various peptide design approaches i.e., in-silico and in-vitro along with their applications and strategies to improve their efficacy. In this review, we try to bring different aspects of peptide-based therapeutics under one article with a clear focus to cover the missing links in the literature. This review draws emphasis on various in-silico approaches and modification-based peptide design strategies. It also highlights the recent progress made in peptide delivery methods important for their enhanced clinical efficacy. The article would provide a bird’s-eye view to researchers aiming to develop peptides with therapeutic applications. Graphical Abstract

show abstract

Section: Strategies To Overcome the Limitationsmentioning

confidence: 99%

Section: Peptide-based Drug Deliverymentioning

confidence: 99%

Strategic Approaches to Improvise Peptide Drugs as Next Generation Therapeutics

Barman

Joshi

Sharma

et al. 2023

Int J Pept Res Ther

View full text Add to dashboard Cite

show abstract

“…Cancer cells have cell surface receptors that are up-regulated and overexpressed in the plasma membrane. These receptors are absent or present at a much lower level in normal cells, allowing them to be used for cancer-targeted detection (Shah et al 2020 ). Peptidomimetics may be able to act on diagnostic areas by molecular imaging.…”

Section: Peptidomimetics Facilitated Cancer Diagnosismentioning

confidence: 99%

Peptidomimetics in cancer targeting

Gomari

Abkhiz

Pour

et al. 2022

Mol Med

View full text Add to dashboard Cite

The low efficiency of treatment strategies is one of the main obstacles to developing cancer inhibitors. Up to now, various classes of therapeutics have been developed to inhibit cancer progression. Peptides due to their small size and easy production compared to proteins are highly regarded in designing cancer vaccines and oncogenic pathway inhibitors. Although peptides seem to be a suitable therapeutic option, their short lifespan, instability, and low binding affinity for their target have not been widely applicable against malignant tumors. Given the peptides’ disadvantages, a new class of agents called peptidomimetic has been introduced. With advances in physical chemistry and biochemistry, as well as increased knowledge about biomolecule structures, it is now possible to chemically modify peptides to develop efficient peptidomimetics. In recent years, numerous studies have been performed to the evaluation of the effectiveness of peptidomimetics in inhibiting metastasis, angiogenesis, and cancerous cell growth. Here, we offer a comprehensive review of designed peptidomimetics to diagnose and treat cancer.

show abstract

“…Further, several homopolypeptides, such as poly-L-lysine and poly-L-arginine, that belong to the class of cell-penetrating peptides (CPPs), have antibacterial properties. [42][43][44][45][46][47] CPPs penetrate the cell membrane through two independent mechanisms: one involving endocytosis and the other membrane translocation, [48][49][50][51][52] often leaving the membrane intact. However, the precise mechanism of the antibacterial action of CPPs remain incompletely understood.…”

Section: Introductionmentioning

confidence: 99%