Polyadenylation of histone mRNA in <i>Xenopus</i> oocytes and embryos

Ballantine, Josiah; Woodland, Hugh R.

doi:10.1016/0014-5793(85)81075-9

Cited by 43 publications

(33 citation statements)

References 30 publications

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“…Even though during Xenopus maturation and early embryogenesis where adenylation correlating with translational activation is the general rule, histone mRNAs deadenylation coincides with their translational activation. At least, in the case of histone H4 mRNA the deadenylation dependent maturation involves complete removal of the poly(A) tail (Ballantine and Woodland, 1985). Similar results have been obtained in mammalian spermiogenesis in which shortening of the poly(A) tail of the protamine mRNA occurs at the same time as translation of this mRNA commences (Kleene, 1989).…”

Section: Introductionsupporting

confidence: 75%

The polyadenylation inhibitor cordycepin (3′dA) causes a decline in c-MYC mRNA levels without affecting c-MYC protein levels

et al. 1999

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Section: Introductionsupporting

confidence: 75%

The polyadenylation inhibitor cordycepin (3′dA) causes a decline in c-MYC mRNA levels without affecting c-MYC protein levels

et al. 1999

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“…Short poly(A) tails (less than 20 nucleotides), added to the 3' end of an intact stem-loop sequence, were observed before for histone mRNAs in Xenopus oocytes (Ballantine and Woodland, 1985). These tails were removed upon fertilization and they were implicated in the control of histone mRNA translation (Ruderman et al, 1979).…”

Section: Discussionmentioning

confidence: 99%

Two Types of Polyadenated mRNAs are Synthesized from Drosophila Replication‐Dependent Histone Genes

Akhmanova¹,

Miedema²,

Kremer³

et al. 1997

European Journal of Biochemistry

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The polyadenylation of replication-dependent histone H2B, H 3 and H4 mRNAs in Drosophilu melanoguster was analysed. Two types of mRNAs, containing a poly(A) tail, can be detected in addition to non-polyadenylated messengers, which represent the majority of replication-dependent histone mRNAs. Firstly, conventional polyadenylation signals, localized downstream from the stem-loop region, are used to produce polyadenylated mRNAs. The messengers of this type, generated from the D. melanogaster H2B gene, are preferentially synthesized in the testis of the fly. Secondly, a distinct type of polyadenylated histone mRNA has been identified. This mRNA, which is present in many different tissues and constitutes a minor part of the total histone mRNA pool, contains a short poly(A) tail, added to the end of the 3' terminal stem-loop structure, which is in most cases lacking several nucleotides from its 3' end. The sites of polyadenylation within the stem-loop are not preceded by a nornial polyadenylation signal. The possible functions of the polyadenylated histone transcripts are discussed.

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“…Furthermore, heat shock effects in Drosophila melanogastei embryos include alterations in poly(A) tail lengths that correlate with translational efficiency (Storti et al 1980). In contrast, deadenylation of specific RNAs can result in an increase in translatability as shown during early Xenopus embryogenesis, when dead enylation of histone mRNA actually facilitates transla tion activation of core histone messages (Ballantine and Woodland 1985).…”

mentioning

confidence: 99%