Polyacrylonitrile Thin-Film Composite Membranes for the Optimization of a Whole Blood Glucose Sensor

An investigation into the hemo-biocompatibility of calix [4]resorcinarenetetrathiol and calix-PEG derivative coatings on gold electrodes is reported, with respect to the detection of the ascorbate ion in aqueous solution. The electrochemical behavior of the ascorbate ion at calix-modified electrodes is also discussed. Findings show that a facilitated adsorption of ascorbate from solution is seen at calix-modified gold electrodes. Following exposure to whole human blood, calix-PEG derivative coatings were seen to offer some protection against both outer-surface biofouling and electrode passivation effects in comparison to calix[4]resorcinarenetetrathiol counterparts. The individual effects of outer surface biofouling and electrode passivation on exposure to whole blood have been investigated. Our findings suggest that PEG moieties help prevent sorption of the biofouling film, thus possibly minimizing the release of a number of low molecular weight solutes which are thought to be involved with the passivation of electrode responses within clinical bio-and chemical sensors.

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Flexible Ultrathin PolyDVB/EVB Composite Membranes for the Optimization of a Lactate Sensor

Bridge

Davis

Collyer

et al. 2007

Electroanalysis

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An ultrathin composite membrane has been developed as the outer covering barrier in a model amperometric lactate oxidase enzyme electrode. The membrane was formed by cathodic electropolymerization of divinylbenzene/ ethylvinylbenzene at the surface of a gold coated polyester support membrane. Permeability coefficients were determined for O 2 and lactate across membranes with a range of polymer thicknesses. Anionic interferents (such as ascorbate) were screened from the working electrode by the composite membrane. The composite enzyme electrode showed an increased working concentration range and extended linearity of responses in comparison to an uncoated enzyme electrode.

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Polyacrylonitrile Thin-Film Composite Membranes for the Optimization of a Whole Blood Glucose Sensor

Cited by 5 publications

References 11 publications

Utilization of Polymers in Sensor Devices

Utilization of Polymers in Sensor Devices

An Investigation into Outer‐Surface Biofouling and Electrode Passivation Effects on Gold Electrodes Modified with Calix[4]resorcinarenetetrathiol and a PEG Derivative on Exposure to Whole Human Blood

Flexible Ultrathin PolyDVB/EVB Composite Membranes for the Optimization of a Lactate Sensor

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