Polyacrylonitrile Membrane Interposition Between a Xenograft and an Animal in Fulminant Liver Failure

Argibay, Pablo; Vázquez, Juan Carlos Rodríguez; Hyon, Sung Ho; Garcia, Hernan; Nunez, F Alcala-Santaella

doi:10.1097/00002480-199609000-00022

Cited by 1 publication

(2 citation statements)

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“…Another commonly used surgical model involved PCA plus hepatic artery ligation. This has been described in rats, rabbits, dogs, and pigs, though not in mice, presumably because it is made more impracticable by their size ( Fick, Schalm & de Vlieger, 1987 ; Bonato et al, 1989 ; Ash et al, 1993 ; Argibay et al, 1996 ). PCA may be done at the same time as arterial ligation or separately.…”

Section: Survey Methodologymentioning

confidence: 99%

“…Broadly, artificially-induced preclinical ALF models can be grouped into surgical, pharmacological or immunogenic approaches ( Table 1 ). Common techniques used in surgical models include total hepatectomy, major liver resection, temporary hepatic ischemia, and a combination of portacaval shunting with hepatic artery ligation ( Argibay et al, 1996 ; Groot et al, 1987 ; Makino et al, 2005 ; Yamaguchi et al, 1989 ). A range of pharmacological models have also been studied.…”

Section: Introductionmentioning

confidence: 99%

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Preclinical models of acute liver failure: a comprehensive review

Hefler

Marfil‐Garza

Pawlick

et al. 2021

PeerJ

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Acute liver failure is marked by the rapid deterioration of liver function in a previously well patient over period of days to weeks. Though relatively rare, it is associated with high morbidity and mortality. This makes it a challenging disease to study clinically, necessitating reliance on preclinical models as means to explore pathophysiology and novel therapies. Preclinical models of acute liver failure are artificial by nature, and generally fall into one of three categories: surgical, pharmacologic or immunogenic. This article reviews preclinical models of acute liver failure and considers their relevance in modeling clinical disease.

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