Polyacrylic acid/ polyvinylpyrrolidone hydrogel wound dressing containing zinc oxide nanoparticles promote wound healing in a rat model of excision injury

Shahrousvand, Mohsen; Mirmasoudi, Seyyedeh Sahra; Pourmohammadi-Bejarpasi, Zahra; Feizkhah, Alireza; Mobayen, Mohammadreza; Hedayati, Mojtaba; Sadeghi, Mahsa; Esmailzadeh, Mojdeh; Mirkatoul, Fatemeh Beygom; Jamshidi, Solma

doi:10.1016/j.heliyon.2023.e19230

Cited by 9 publications

(2 citation statements)

References 40 publications

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“…Radiation cross-linking removes the need for an initiator and cross-linking agent and allows for easy manipulation of the hydrogel properties [86]. PVP can absorb water up to a magnitude of one hundred times its mass, which facilitates the preservation of moisture [87]. The semi-permeable nature of PVP enables the selective permeation of oxygen while effectively impeding the ingress of bacteria and other contaminants.…”

Section: Polyvinylpyrrolidone (Pvp)mentioning

confidence: 99%

Hydrogels and Wound Healing: Current and Future Prospects

Gounden,

Singh

2024

Gels

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The care and rehabilitation of acute and chronic wounds have a significant social and economic impact on patients and global health. This burden is primarily due to the adverse effects of infections, prolonged recovery, and the associated treatment costs. Chronic wounds can be treated with a variety of approaches, which include surgery, negative pressure wound therapy, wound dressings, and hyperbaric oxygen therapy. However, each of these strategies has an array of limitations. The existing dry wound dressings lack functionality in promoting wound healing and exacerbating pain by adhering to the wound. Hydrogels, which are commonly polymer-based and swell in water, have been proposed as potential remedies due to their ability to provide a moist environment that facilitates wound healing. Their unique composition enables them to absorb wound exudates, exhibit shape adaptability, and be modified to incorporate active compounds such as growth factors and antibacterial compounds. This review provides an updated discussion of the leading natural and synthetic hydrogels utilized in wound healing, details the latest advancements in hydrogel technology, and explores alternate approaches in this field. Search engines Scopus, PubMed, Science Direct, and Web of Science were utilized to review the advances in hydrogel applications over the last fifteen years.

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Section: Polyvinylpyrrolidone (Pvp)mentioning

confidence: 99%

Hydrogels and Wound Healing: Current and Future Prospects

Gounden,

Singh

2024

Gels

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“…Furthermore, due to the loading of ZnO nanoparticles, the inhibitory effect of the system on Pseudomonas arauginosa was significantly improved and the wound contraction rate was accelerated on a rat excisional wound injury model. 10 As a wound dressing and effective drug delivery system, PAA hydrogels can maintain inherent bactericidal properties and effectively deliver active drugs to regulate endogenous factors in cells. They provide antibacterial properties of topical drug delivery systems for wounds, with promising application prospects.…”

Section: Introductionmentioning

confidence: 99%

Design and Self-Assembly of Peptide-Copolymer Conjugates into Nanoparticle Hydrogel for Wound Healing in Diabetes

Lin,

Zhang,

Cai

et al. 2024

IJN

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Background Delayed wound healing in skin injuries has become a significant problem in clinics, seriously affecting and even threatening life and health. Recently, research interest has increased in developing wound dressings containing bioactive compounds capable of improving outcomes for complex healing needs. Methods In this study, Puerarin -loaded nanoparticles (Pue-NPs) were prepared using the cell-penetrating peptide-poly (lactic-co-glycolic acid) (CPP-PLGA) as a drug carrier by the emulsified solvent evaporation method. Then, they were added into poly (acrylic acid) to obtain a self-assembled nanocomposite hydrogels (SANHs) drug delivery system using the co-polymerization method. The particle size, zeta potential, and micromorphology of Pue-NPs were measured; the appearance, mechanical properties, adhesive strength, and biological activity of SANHs were performed. Finally, the potential of SANHs for wound healing was further evaluated in streptozotocin-induced diabetic mice. Results Pue-NPs were regularly spherical, with an average particle size of 134.57 ± 1.42 nm and a zeta potential of 2.14 ± 0.78 mV. SANHs was colorless and transparent with a honeycomb-like porous structure and had an excellent swelling ratio (917%), water vapor transmission rate (3077 g·m −2 ·day −1 ), mechanical properties (Young’s modulus of 18 kPa, elongation at break of 307%), and adhesive strength (15.5 kPa). SANHs exhibited sustained release of Pue over 48h, with a cumulative release of 55.60 ± 6.01%. In vitro tests revealed that the SANHs presented a 92.22% antibacterial rate against Escherichia coli after 4h, and a 61.91% scavenging rate of 1.1-diphenyl-2-trinitrophenylhydrazine (DPPH) radical. In vivo experiments showed that SANHs accelerated wound repair by reducing the inflammatory response at the wound site, promoting angiogenesis, and facilitating epidermal regeneration and collagen deposition. Conclusion In conclusion, we successfully prepared SANHs. Our results show that SANHs have excellent performance and improves wound healing in diabetic mice model, indicating that it can be used to develop an effective strategy for the treatment of diabetic wounds.

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