Polyacrylic acid complexes to mineralize ultrasmall europium-doped calcium phosphate nanodots for fluorescent bioimaging

Ding, Ziyou; Xing, Qingguo; Fan, Yiran; Song, Qifa; Song, Chunhui; Han, Yingchao

doi:10.1016/j.matdes.2022.111008

Cited by 5 publications

(2 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…3− can be observed at 1067 and 553 cm −1 , respectively. [37] The aforementioned results effectively showcased the perfect synthesis of each step, which were further verified by monitoring the zeta potential of the material during the synthesis process. As shown in Figure 1j, the zeta potentials of the as-prepared ZnS are +12.3 mV.…”

Section: Structure and Compositionsmentioning

confidence: 57%

A Multichannel Metabolic Pathway Interference Strategy for Complete Energy Depletion‐Mediated Cancer Therapy

Ding,

Wei,

Fang

et al. 2024

Adv Funct Materials

View full text Add to dashboard Cite

Hydrogen sulfide (H2S) is being progressively integrated as an emerging inhibitor of the electron transport chain in energy interference‐based tumor therapy. However, metabolic reprogramming in cancer cells causes both oxidative phosphorylation (OXPHOS) and glycolysis to occur simultaneously, which contributes to the ineffective therapeutic effect of blocking a single pathway. To achieve complete suppression of energy production, an inorganic H2S donor ZnS@ZIF‐8@CaP nanoparticle (ZSZC NP) carrying Ca and Zn is constructed for achieving simultaneous interference of OXPHOS and glycolysis. The core–shell ZSZC nanoparticles can break down in the tumor microenvironment. This leads to a sustained H2S release and calcium overload to disrupt the normal functioning of mitochondria by inhibiting the expression of cytochrome c and causing damage to mitochondrial membrane potential. Meanwhile, the presence of Zn2+ hinders the typical process of glycolysis by impeding the functioning of lactate dehydrogenase and glyceraldehyde‐3‐phosphate dehydrogenase. The synchronous interference of OXPHOS and glycolysis hampers the energy supply to cancer cells. Additionally, H2S and calcium overload can expedite tumor necrosis in vivo by inducing cellular acidification and calcification. Therefore, this energy‐blocking strategy will completely deplete the energy reserves of cancer cells and provide new insights for exploring bioenergetic inhibition as a treatment approach.

show abstract

Section: Structure and Compositionsmentioning

confidence: 57%

A Multichannel Metabolic Pathway Interference Strategy for Complete Energy Depletion‐Mediated Cancer Therapy

Ding,

Wei,

Fang

et al. 2024

Adv Funct Materials

View full text Add to dashboard Cite

show abstract

“…Finally, the application of the probe in the quantitative detection of ALP of rat serum was attempted. 49 the PAA-Ca(Ce) nanoclusters were synthesized at room temperature. First, 2.25 mL of CeCl 3 (0.0334 M) and 2.25 mL of CaCl 2 (0.3 M) were added to 15.5 mL of ultrapure water and stirred constantly at room temperature.…”

Section: Introductionmentioning

confidence: 99%

Polyacrylic Acid-Ca²⁺(Ce³⁺) Nanoclusters as Fluorescent “Off–On–Off” Probes for Quantitative Detection of Pyrophosphate and Alkaline Phosphatase

Fan,

Ding,

Chen

et al. 2024

ACS Appl. Nano Mater.

Self Cite

View full text Add to dashboard Cite

Alkaline phosphatase (ALP) is an essential enzyme widely distributed in the human body, and it can hydrolyze pyrophosphate (PPi) under alkaline conditions. Therefore, ALP and PPi activities are associated with many diseases and it is crucial to develop sensitive and selective methods for detecting ALP and PPi. Herein, poly(acrylic acid) (PAA)-Ca 2+ (Ce 3+ ) nanoclusters fluorescent probe was synthesized aiming to detect PPi and ALP quantitatively. The nanoclusters present monodisperse, and their particle size is 0.9−2.4 nm. The probe exhibits no fluorescence due to electron transfer; whereas it can combine with PPi to yield fluorescence increase, arising from the enhanced electric-dipole transition of Ce 3+ under the ligand effect of PPi. Moreover, the probe displays good selectivity to PPi, and the fluorescence changes display a linear relationship with PPi concentration of 3−20 mM (y = 11.29x − 23.47, R 2 = 0.994). Furthermore, the probe was mixed with PPi to form PAA-Ca(Ce):PPi nanoparticle (Monodisperse, average size: 1.94 nm) and showed high fluorescence selectivity and responsiveness to ALP due to the ALP hydrolyzing effect and the fluorescence difference between PAA-Ca(Ce):PPi and PAA-Ca(Ce):Pi. Based on the relationship between the fluorescence reduction rate of the probe and the logarithm of ALP concentration (y = 0.0594x − 0.00111, 5−200 U/L, R 2 = 0.996), ALP was successfully detected quantitatively, and the detection limit is calculated to be 0.62 U/L. Through this approach, we developed a fluorescence "turn-on" for PPi detection and "turn-off" for ALP detection. This study provides a promising strategy for the diagnosis of diseases related to PPi and ALP.

show abstract

Calcium-based nanomaterials for cancer therapy

Huang,

Zhang,

Chen

et al. 2024

J Mater Sci

View full text Add to dashboard Cite

Polyacrylic acid complexes to mineralize ultrasmall europium-doped calcium phosphate nanodots for fluorescent bioimaging

Cited by 5 publications

References 48 publications

A Multichannel Metabolic Pathway Interference Strategy for Complete Energy Depletion‐Mediated Cancer Therapy

A Multichannel Metabolic Pathway Interference Strategy for Complete Energy Depletion‐Mediated Cancer Therapy

Polyacrylic Acid-Ca²⁺(Ce³⁺) Nanoclusters as Fluorescent “Off–On–Off” Probes for Quantitative Detection of Pyrophosphate and Alkaline Phosphatase

Calcium-based nanomaterials for cancer therapy

Contact Info

Product

Resources

About

Polyacrylic acid complexes to mineralize ultrasmall europium-doped calcium phosphate nanodots for fluorescent bioimaging

Cited by 5 publications

References 48 publications

A Multichannel Metabolic Pathway Interference Strategy for Complete Energy Depletion‐Mediated Cancer Therapy

A Multichannel Metabolic Pathway Interference Strategy for Complete Energy Depletion‐Mediated Cancer Therapy

Polyacrylic Acid-Ca2+(Ce3+) Nanoclusters as Fluorescent “Off–On–Off” Probes for Quantitative Detection of Pyrophosphate and Alkaline Phosphatase

Calcium-based nanomaterials for cancer therapy

Contact Info

Product

Resources

About

Polyacrylic Acid-Ca²⁺(Ce³⁺) Nanoclusters as Fluorescent “Off–On–Off” Probes for Quantitative Detection of Pyrophosphate and Alkaline Phosphatase