Polyacrylamide hydrogels prepared by varying water content during polymerization: Material characterization, reswelling ability, and aging resistance

Pěnkavová, Věra; Spalova, Anna; Tomas, Jan; Tihon, J.

doi:10.1002/pen.25895

Cited by 6 publications

(7 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, at the first steps of hydration, the values at each time corresponding to PBS and SBF are slightly higher than those corresponding to water. In fact, Penkavova et al reported that polyacrylamide hydrogels swell more in NaCl solutions than in water [ 55 ]. This behavior has been attributed to the formation of an electric double layer around polar groups of the polymer chain, such as C=O and C-N, which screens the polymer–polymer interactions [ 56 ].…”

Section: Resultsmentioning

confidence: 99%

Antimicrobial-Loaded Polyacrylamide Hydrogels Supported on Titanium as Reservoir for Local Drug Delivery

et al. 2023

View full text Add to dashboard Cite

Arthroplasty is a highly successful treatment to restore the function of a joint. The contamination of the implant via bacterial adhesion is the first step toward the development of device-associated infections. The emerging concern about antimicrobial resistance resulted in a growing interest to develop alternative therapeutic strategies. Thus, the increment in the incidence of bacterial periprosthetic infections, the complexity of treating infections caused by organisms growing in biofilms, together with the rise in antibiotic resistant bacteria, expose the need to design novel surfaces that provide innovative solutions to these rising problems. The aim of this work is to develop a coating on titanium (Ti) suitable for inhibiting bacterial adhesion and proliferation, and hence, biofilm formation on the surface. We have successfully prepared polyacrylamide hydrogels containing the conventional antibiotic ampicillin (AMP), silver nanoparticles (AgNPs), and both, AMP and AgNPs. The release of the antibacterial agents from the gelled to aqueous media resulted in an excellent antibacterial action of the loaded hydrogels against sessile S. aureus. Moreover, a synergic effect was achieved with the incorporation of both AMP and AgNPs in the hydrogel, which highlights the importance of combining antimicrobial agents having different targets. The polyacrylamide hydrogel coating on the Ti surface was successfully achieved, as it was demonstrated by FTIR, contact angle, and AFM measurements. The modified Ti surfaces having the polyacrylamide hydrogel film containing AgNPs and AMP retained the highest antibacterial effect against S. aureus as it was found for the unsupported hydrogels. The modified surfaces exhibit an excellent cytocompatibility, since healthy, flattened MC3T3-E1 cells spread on the surfaces were observed. In addition, similar macrophage RAW 264.7 adhesion was found on all the surfaces, which could be related to a low macrophage activation. Our results indicate that AMP and AgNP-loaded polyacrylamide hydrogel films on Ti are a good alternative for designing efficient antibacterial surfaces having an excellent cytocompatibility without inducing an exacerbated immune response. The approach emerges as a superior alternative to the widely used direct adsorption of therapeutic agents on surfaces, since the antimicrobial-loaded hydrogel coatings open the possibility of modulating the concentration of the antimicrobial agents to enhance bacterial killing, and then, reducing the risk of infections in implantable materials.

show abstract

Section: Resultsmentioning

confidence: 99%

Antimicrobial-Loaded Polyacrylamide Hydrogels Supported on Titanium as Reservoir for Local Drug Delivery

et al. 2023

View full text Add to dashboard Cite

show abstract

“…The sample radius is 10.0 mm, the length is 20.0 mm, and the compression test speed is 100 mm min −1 . The stress ( δ ) and The elongation at break ( ε ) are calculated using formulas (3–4) 40 :…”

Section: Methodsmentioning

confidence: 99%

A novel PVA/MWCNTs hydrogel with high toughness and electromagnetic shielding properties

Xu,

Tan,

Xue

et al. 2023

Polymer Engineering & Sci

View full text Add to dashboard Cite

Carbon nanotubes (CNTs) are widely utilized as conductive fillers due to their high conductivity, lightweight, and ease of modification. However, their poor dispersion limits their otherwise excellent performance. In this study, we successfully prepared a high toughness, strong electromagnetic interference (EMI) shielding hydrogel by blending polyvinyl alcohol (PVA) hydrogel with multi‐walled carbon nanotubes (MWCNTs) modified by anionic surfactant sodium dodecylbenzene sulfonate (SDBS) and (3‐aminopropyl) triethoxysilane (KH550). We found that the modifiers can not only promote the uniform dispersion of MWCNTs but also improve the mechanical properties of the hydrogel. The results demonstrate that the stress (≈14.86 MPA), elongation at break (233.9%), and compressive strength (≈2.89 MPA) of PVA/MWCNTs composite hydrogel with 1 wt% MWCNTs and 5 wt% PVA were increased by 533.6%, 241.4%, and 206.5%, respectively. Encouragingly, the total electromagnetic shielding effectiveness (SET) is 123.6 dB at a thickness of 5 mm. In summary, this work provides a general approach to functionalizing MWCNTs, which has great potential for developing EMI shielding materials with high toughness.

show abstract

“…Polyacrylamide (PAAM)-based hydrogels have garnered considerable attention in the research community for their versatility and potential applications in various fields. − Their tunable mechanical properties offer flexibility in tailoring the hydrogel’s stiffness, elasticity, and strength to suit specific requirements, making them ideal for diverse applications ranging from tissue engineering to drug delivery. − Moreover, their biocompatibility ensures minimal adverse reactions when they are in contact with living tissues, making them well-suited for biomedical applications. Discher et al investigated the impact of various stiffness levels in PAAM-based hydrogels and revealed that these hydrogels can mimic different types of tissues.…”

Section: Introductionmentioning

confidence: 99%

Composite Hydrogel Modified with Gelatin-Imidazole: A Conductive and Adhesive Hydrogel

Zhang,

Liu,

Chu

et al. 2023

ACS Appl. Electron. Mater.

View full text Add to dashboard Cite

Wearable sensors have the potential to revolutionize healthcare, sports, and overall well-being by offering personalized, continuous monitoring and actionable insights. They empower individuals to proactively manage their health, enhance clinical diagnostics, and advance preventive and precision healthcare. In this study, we developed conductive hydrogels containing acrylamide (AAM), polyacrylamide (PAAM), chemically modified poly(ethylene glycol) (DF-PEG), gelatin (Gel-ICM), and imidazole (SBVI). The investigation focused on the influence of different SBVI amounts on the hydrogel's mechanical and electrical properties. Specifically, we labeled hydrogels with 0, 0.5, 1.0, 1.5, and 2.0% w/v SBVI as CH-0, CH-0.5, CH-1, CH-1.5, and CH-2, respectively. Our experimental results showed a 165% increase in elongation at break and a 63% decrease in electrical resistance for CH-1 compared to the CH-0 hydrogel. Moreover, the consistent relative resistance responses observed across various human joint movements, different strain rate tests, and durability assessments underscore the reliability and versatility of the CH-1 hydrogel as a strain sensor for potential applications in wearable electronic devices and biomechanical monitoring systems. These findings provide valuable insights for researchers in designing hydrogel-based materials with tailored electrical properties, unlocking their potential for a wide array of cutting-edge applications.

show abstract

Polyacrylamide hydrogels prepared by varying water content during polymerization: Material characterization, reswelling ability, and aging resistance

Cited by 6 publications

References 59 publications

Antimicrobial-Loaded Polyacrylamide Hydrogels Supported on Titanium as Reservoir for Local Drug Delivery

Antimicrobial-Loaded Polyacrylamide Hydrogels Supported on Titanium as Reservoir for Local Drug Delivery

A novel PVA/MWCNTs hydrogel with high toughness and electromagnetic shielding properties

Composite Hydrogel Modified with Gelatin-Imidazole: A Conductive and Adhesive Hydrogel

Contact Info

Product

Resources

About