Polyacrylamide-gelatin polymeric networks: effect of pH and gelatin concentration on the swelling kinetics and mechanical properties

Martínez-Ruvalcaba, A.; Becerra-Bracamontes, Fausto; Sánchez-Díaz, J. C.; González-Álvarez, Alejandro

doi:10.1007/s00289-008-0037-4

Cited by 29 publications

(14 citation statements)

References 19 publications

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“…This phenomenon could explain the fast complete dissolution of gelation. The reported results are quite in agreement with other studies on crosslinked gelatin beads [76], polyacrylamide-gelatin [74], cross-linked acrylic acid/gelatin hydrogels [77], gelatin-based nanospheres [78] and gelatin-sodium carboxymethyl cellulose [79].…”

Section: Swelling and Deswelling Behaviorsupporting

confidence: 92%

“…Ionic repulsion between charged groups incorporated in the gelatin matrix could be assumed to be the main driving force responsible for the swelling behaviour. As pH changes, due to the ionizable groups in gelatin chains, there are hydrostatic repulsion between them so, as gelatin beads adsorb water molecules, these latter occupy a certain volume and, as a consequence, an expansion of the structure occurrs [74]. Besides, the higher swelling at basic pH could be ascribed to the possibility of forming a porous structure due to alkaline hydrolysis [46].…”

Section: Swelling and Deswelling Behaviormentioning

confidence: 99%

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Gelatin Beads/Hemp Hurd as pH Sensitive Devices for Delivery of Eugenol as Green Pesticide

Viscusi

Gorrasi

2021

J Polym Environ

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In this paper gelatin beads reinforced with natural hemp hurd have been produced as pH sensitive devices for the release of eugenol, as green pesticide. The composites beads, with a mean diameter of about 1 mm, were obtained by polymer droplet gelation in sunflower oil. Thermal properties were evaluated showing no noticeable difference after the introduction of hemp hurd. Barrier properties demonstrated an improvement of hydrophobization. The introduction of 5% w/w of hemp hurd led to a reduction of sorption coefficient of about 85% compared to unloaded gelatin beads. Besides, the diffusion coefficient decreased, introducing 5% w/w of hemp hurd, from 8.91 × 10−7 to 0.77 × 10−7 cm2/s. Swelling and dissolution phenomena of gelatin beads were studied as function of pH. The swelling of gelatin beads raised as pH increased up to 2.3 g/g, 9.1 g/g and 27.33 g/g at pH 3, 7 and 12, respectively. The dissolution rate changed from 0.034 at pH 3 to 0.077 h−1 at pH 12. Release kinetics of eugenol at different pH conditions were studied. The released eugenol after 24 h is 98%, 91%, 81 and 63% w/w (pH 3), 87%, 62%, 37 and 32 wt% (pH 7) and 81%, 68%, 60 and 52 wt% (pH 12) for unloaded gelatin beads and gelatin beads with 1%, 3 and 5% of hemp hurd, respectively. The eugenol release behavior was demonstrated to be highly sensitive to the pH release medium, which allows to tune such devices as green pesticide release systems in soils with different level of acidity/basicity.

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Section: Swelling and Deswelling Behaviorsupporting

confidence: 92%

Section: Swelling and Deswelling Behaviormentioning

confidence: 99%

Gelatin Beads/Hemp Hurd as pH Sensitive Devices for Delivery of Eugenol as Green Pesticide

Viscusi

Gorrasi

2021

J Polym Environ

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“…The effect of pH on the swelling of polyacrylamide (PAM) hydrogel is known because of the presence of the ionizable amide group (–CONH 2 ) which upon base hydrolysis gets converted into carboxylate (–COO – ) ion . So the possible contribution of PAM segments to the pH effect on the swelling properties of the DN hydrogels especially in high alkaline medium cannot be ignored.…”

Section: Resultsmentioning

confidence: 99%

“…The effect of pH on the swelling of polyacrylamide (PAM) hydrogel is known because of the presence of the ionizable amide group (-CONH 2 ) which upon base hydrolysis gets converted into carboxylate (-COO -) ion. 62,63 So the possible contribution of PAM segments to the pH effect on the swelling properties of the DN hydrogels especially in high alkaline medium cannot be ignored. The role of PAM segments in the effect of pH on the swelling of DN hydrogels can be understood for the GS-1 hydrogel sample which contains only PAM as the second network (no Na-AA) (Fig.…”

Section: Ph-responsive Behaviourmentioning

confidence: 99%

Synthesis of multifunctional high strength, highly swellable, stretchable and self‐healable pH‐responsive ionic double network hydrogels

Dixit

Bag

Sharma

et al. 2018

Polymer International

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The multifunctional double network (DN) soft hydrogels reported here are highly swellable and stretchable pH‐responsive smart hydrogel materials with sufficient strength and self‐healing properties. Such multifunctional hydrogels are achieved using double crosslinking structures with multiple physical and chemical crosslinks. They consist of a copolymer network of acrylamide (AM) and sodium acrylate (Na‐AA) and other reversible network of poly(vinyl alcohol)–borax complex. They were characterized by Fourier transform IR analysis and studied for their hydrogen bonding and ionic interaction. The degree of equilibrium swelling was observed to be as high as 5959% (at pH 7.0) for a hydrogel with AM/Na‐AA = 25/75 wt% in the network (GS‐6 sample). The highest degree of swelling was observed to be 6494% at pH 8.5. The maximum tensile strength was measured to be 1670, 580 and 130 kPa for a DN hydrogel (GS‐2 sample: AM/Na‐AA =75/25 wt% with 20, 40 and 60 wt% water content, respectively). The self‐healing efficiency was estimated to be 69% for such a hydrogel. These multifunctional DN hydrogels with amalgamation of many functional properties are unique in hydrogel materials and such materials may find applications in sensors, actuators, smart windows and biomedical applications. © 2018 Society of Chemical Industry

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“…Then, the samples were removed from the buffer solution at fixed times, wiped with a paper and reweighed (W t ). WU was calculated using the following equation [37]:…”

Section: Water Uptake (Wu) Measurementsmentioning

confidence: 99%

Lactose-crosslinked fish gelatin-based porous scaffolds embedded with tetrahydrocurcumin for cartilage regeneration

Etxabide

Ribeiro

Ferreira

et al. 2018

International Journal of Biological Macromolecules

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Tetrahydrocurcumin (THC) is one of the major colourless metabolites of curcumin and shows even greater pharmacological and physiological benefits. The aim of this work was the manufacturing of porous scaffolds as a carrier of THC under physiological conditions. Fish-derived gelatin scaffolds were prepared by freeze-drying by two solutions concentrations (2.5% and 4% w/v), cross-linked via addition of lactose and heat-treated at 105 °C. This cross-linking reaction resulted in more water resistant scaffolds with a water uptake capacity higher than 800%. Along with the cross-linking reaction, the gelatin concentration affected the scaffold morphology, as observed by scanning electron microscopy images, by obtaining a reduced porosity but larger pores sizes when the initial gelatin concentration was increased. These morphological changes led to a scaffold's strength enhancement from 0.92 ± 0.22 MPa to 2.04 ± 0.18 MPa when gelatin concentration was increased. THC release slowed down when gelatin concentration increased from 2.5 to 4% w/v, showing a controlled profile within 96 h. Preliminary in vitro test with chondrocytes on scaffolds with 4% w/v gelatin offered higher metabolic activities and cell survival up to 14 days of incubation. Finally the addition of THC did not influence significantly the cytocompatibility and potential antibacterial properties were demonstrated successfully against Staphylococcus aureus.

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Polyacrylamide-gelatin polymeric networks: effect of pH and gelatin concentration on the swelling kinetics and mechanical properties

Cited by 29 publications

References 19 publications

Gelatin Beads/Hemp Hurd as pH Sensitive Devices for Delivery of Eugenol as Green Pesticide

Gelatin Beads/Hemp Hurd as pH Sensitive Devices for Delivery of Eugenol as Green Pesticide

Synthesis of multifunctional high strength, highly swellable, stretchable and self‐healable pH‐responsive ionic double network hydrogels

Lactose-crosslinked fish gelatin-based porous scaffolds embedded with tetrahydrocurcumin for cartilage regeneration

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