Polyacrylamide gel containing egg white as new model for irradiation experiments using focused ultrasound

Purpose: Quantification of stiffness changes may provide important diagnostic information and aid in the early detection of cancers. Shear wave elastography is an imaging technique that assesses tissue stiffness using acoustic radiation force as an alternate to manual palpation reported previously with quasistatic elastography. In this study, the elastic properties of tissue mimicking materials, including agar, polyacrylamide (PAA), and silicone, are evaluated with an objective to determine material characteristics which resemble normal and cancerous prostate tissue. Methods: Acoustic properties and stiffness of tissue mimicking phantoms were measured using compressional mechanical testing and shear wave elastography using supersonic shear imaging. The latter is based on the principles of shear waves generated using acoustic radiation force. The evaluation included tissue mimicking materials (TMMs) within the prostate at different positions and sizes that could mimic cancerous and normal prostate tissue. Patient data on normal and prostate cancer tissues quantified using biopsy histopathology were used to validate the findings. Pathologist reports on histopathology were blinded to mechanical testing and elastographic findings.

show abstract

“…The concentration and procedure utilized in this paper were based on the previously reported methods. 28,34 …”

Section: Iib2 Paamentioning

confidence: 99%

Tissue mimicking materials for the detection of prostate cancer using shear wave elastography: A validation study

et al. 2013

View full text Add to dashboard Cite

show abstract

“…This recipe results in a solid gel with acoustical properties close to those of soft tissues (c ¼ 1542 m=s and a ¼ 0.024 Np=cm=MHz). 44 The presence of egg whites makes the phantom become opaque when heated. This property allowed us to identify qualitatively the "ablated volume" or lesion shape in three dimensions.…”

Section: Iig Lesions In Gel Phantomsmentioning

confidence: 99%

“…This property allowed us to identify qualitatively the "ablated volume" or lesion shape in three dimensions. 44 For our recipe, we measured a transition temperature around 62 C. After preparation, the mixture was poured into a mold. Once the mixture solidified, it was taken out of the mold and used immediately for experiments.…”

Section: Iig Lesions In Gel Phantomsmentioning

confidence: 99%

SonoKnife: Feasibility of a line‐focused ultrasound device for thermal ablation therapy

et al. 2011

View full text Add to dashboard Cite

Purpose: To evaluate the feasibility of line-focused ultrasound for thermal ablation of superficially located tumors. Methods: A SonoKnife is a cylindrical-section ultrasound transducer designed to radiate from its concave surface. This geometry generates a line-focus or acoustic edge. The motivation for this approach was the noninvasive thermal ablation of advanced head and neck tumors and positive neck nodes in reasonable treatment times. Line-focusing may offer advantages over the common point-focusing of spherically curved radiators such as faster coverage of a target volume by scanning of the acoustic edge. In this paper, The authors report studies using numerical models and phantom and ex vivo experiments using a SonoKnife prototype. Results: Acoustic edges were generated by cylindrical-section single-element ultrasound transducers numerically, and by the prototype experimentally. Numerically, simulations were performed to characterize the acoustic edge for basic design parameters: transducer dimensions, line-focus depth, frequency, and coupling thickness. The dimensions of the acoustic edge as a function of these parameters were determined. In addition, a step-scanning simulation produced a large thermal lesion in a reasonable treatment time. Experimentally, pressure distributions measured in degassed water agreed well with acoustic simulations, and sonication experiments in gel phantoms and ex vivo porcine liver samples produced lesions similar to those predicted with acoustic and thermal models. Conclusions: Results support the feasibility of noninvasive thermal ablation with a SonoKnife.

show abstract

“…However, there are lots of tissues mimicking materials for ultrasound phantoms, including agar (polysaccharide), oil gel [4], polyvinyl alcohol gel (PVA) [5], poly acryl amide gel (PAA) [6], Since 1993, polymeric materials have been used widely in many industries. Among them are transportation, energy production, agriculture, the building industry, retail, packaging consumer goods, foods, and the health and pharmaceutical industries.…”

Section: Introductionmentioning

confidence: 99%

Ultrasound Speed of Polymer Gel Mimicked Human Soft Tissue within Three Weeks

Othman¹,

Jaafar²,

Rahman³

et al. 2011

IJBBB

View full text Add to dashboard Cite

Abstract-A Polymer gel mimicked human soft tissue was being fabricated using a monomer named 2-Hydroxyl-Ethyl-Acrylate (HEA) with the present of gelatin. The readymade gel which is the concentration for HEA fixed at 5% was then undergoes an ultrasonic evaluation to test for the propagation of sound speed through it. Sonic Waves Analyzer is absolutely the most accurate technique to determine the aims (changes of speed as function of polymer structure /stiffness over time). The fixed frequency of transducers involved is at 500 kHz by using the seismic reflection concept. In the observation of relationship between the ultrasound propagation speeds as the day increased, the propagation speed still varies between 1390 to 1500 m/s which is still in the range of speed of sound for human tissue.Index Terms-Tissue mimicking, ultrasound phantom, abdominal ultrasound, ultrasound propagation speed

show abstract

Polyacrylamide gel containing egg white as new model for irradiation experiments using focused ultrasound

Cited by 135 publications

References 5 publications

Tissue mimicking materials for the detection of prostate cancer using shear wave elastography: A validation study

Tissue mimicking materials for the detection of prostate cancer using shear wave elastography: A validation study

SonoKnife: Feasibility of a line‐focused ultrasound device for thermal ablation therapy

Ultrasound Speed of Polymer Gel Mimicked Human Soft Tissue within Three Weeks

Contact Info

Product

Resources

About