Polyacrylamide ferrogels with embedded maghemite nanoparticles for biomedical engineering

Blyakhman, F. A.; Сафронов, А. П.; Zubarev, A. Yu.; Shklyar, T. F.; Makeyev, Oleg H.; Макарова, Е. Б.; Melekhin, Vsevolod V.; Larrañaga, Aitor; Kurlyandskaya, G. V.

doi:10.1016/j.rinp.2017.09.042

Cited by 46 publications

(42 citation statements)

References 44 publications

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“…Understanding not only the individual evolution of these parameters with scale, magnetic field, temperature, but also their interaction, mutual and with the surrounding environment, is of paramount importance to the design and application of intelligent and multifunctional magnetic nanoparticles (MNP). In biomedicine, MNPs and in particular superparamagnetic iron oxides (SPIO) have a wide range of applications such as magnetic particle imaging (MPI) [6], drug delivery [7], magnetic hyperthermia (MH) [8][9][10], MRI [11], cell tracking [12,13], magnetic biosensors [14,15], regenerative medicine and tissue engineering [16,17], etc. When used as MRI contrast agents (CA) SPIOs can reduce both T 1 and T 2 relaxation times and hence enhance tissue contrast [18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Reduction of T2 Relaxation Rates due to Large Volume Fractions of Magnetic Nanoparticles for All Motional Regimes

Issa

2018

Applied Sciences

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Abstract:The effect of high volume fraction of magnetic nanoparticles (MNP) on Magnetic Resonance Imaging (MRI) transverse relaxation rates (R 2 = 1/T 2 and R 2 * = 1/T 2 *) is investigated using Monte Carlo (MC) simulations. Theoretical models assume that particles occupy a small volume fraction of the sample space. Results presented in this work show that models based on both motional averaged (MAR) and static dephasing (SDR) regimes respectively underestimate and overestimate relaxation rates at large volume fractions. Furthermore, both R 2 * and R 2 * become echo-time dependent. This suggests that diffusion is involved with larger echo-times producing smaller relaxation rates due to better averaging of the magnetic field gradients. Findings emphasize the need for the models to be modified to take account of high particle concentration especially important for application involving clustering and trapping of nanoparticles inside cells. This is important in order to improve the design process of MNP Contrast Agents.

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Section: Introductionmentioning

confidence: 99%

Reduction of T2 Relaxation Rates due to Large Volume Fractions of Magnetic Nanoparticles for All Motional Regimes

Issa

2018

Applied Sciences

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“…This is clear advantage for such application as magnetic biosensing (magnetic fields below 100 Oe [ 12 ]). The second interval for possible applications (100–500 Oe) is connected to idea of the cell use as native microcapsules for targeted delivery in a supplement of nanomedicine and theranostics, cell technologies, and regenerative medicine [ 41 , 42 , 43 ].…”

Section: Resultsmentioning

confidence: 99%

“…Recently we have shown that the presence of LTE MNPs changes the physical properties of ferrogels synthesized by radical polymerization of acrylamide and their biocompatibility [ 43 ]. We found that the gradual increase of MNPs concentration in the gel network resulted in the significant increase of the negative value of electrical potential and adhesion index for both the human dermal fibroblasts and the human peripheral blood leucocytes.…”

Section: Resultsmentioning

confidence: 99%

Water-Based Suspensions of Iron Oxide Nanoparticles with Electrostatic or Steric Stabilization by Chitosan: Fabrication, Characterization and Biocompatibility

Kurlyandskaya

Litvinova

Сафронов

et al. 2017

Sensors

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Present day biomedical applications, including magnetic biosensing, demand better understanding of the interactions between living systems and magnetic nanoparticles (MNPs). In this work spherical MNPs of maghemite were obtained by a highly productive laser target evaporation technique. XRD analysis confirmed the inverse spinel structure of the MNPs (space group Fd-3m). The ensemble obeyed a lognormal size distribution with the median value 26.8 nm and dispersion 0.362. Stabilized water-based suspensions were fabricated using electrostatic or steric stabilization by the natural polymer chitosan. The encapsulation of the MNPs by chitosan makes them resistant to the unfavorable factors for colloidal stability typically present in physiological conditions such as pH and high ionic force. Controlled amounts of suspensions were used for in vitro experiments with human blood mononuclear leukocytes (HBMLs) in order to study their morphofunctional response. For sake of comparison the results obtained in the present study were analyzed together with our previous results of the study of similar suspensions with human mesenchymal stem cells. Suspensions with and without chitosan enhanced the secretion of cytokines by a 24-h culture of HBMLs compared to a control without MNPs. At a dose of 2.3, the MTD of chitosan promotes the stimulating effect of MNPs on cells. In the dose range of MNPs 10–1000 MTD, chitosan “inhibits” cellular secretory activity compared to MNPs without chitosan. Both suspensions did not caused cell death by necrosis, hence, the secretion of cytokines is due to the enhancement of the functional activity of HBMLs. Increased accumulation of MNP with chitosan in the cell fraction at 100 MTD for 24 h exposure, may be due to fixation of chitosan on the outer membrane of HBMLs. The discussed results can be used for an addressed design of cell delivery/removal incorporating multiple activities because of cell capability to avoid phagocytosis by immune cells. They are also promising for the field of biosensor development for the detection of magnetic labels.

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“…Magnetic polymer gels (ferrogels) are a new and promising class of nanocomposite hydrogels that have the potential to be used as effective absorbents of toxic ions in water, protein immobilization, separation, in soft actuators such as artificial muscles, in tissue engineering, drug delivery and hyperthermia applications [ 1 , 2 , 3 , 4 , 5 , 6 , 7 ]. Ferrogels combine the elastic properties and the defined structure of gels with the magnetic properties of magnetic nanoparticles (usually magnetite or maghemite) and respond quickly to the external magnetic field.…”

Section: Introductionmentioning

confidence: 99%

“…Ferrogels combine the elastic properties and the defined structure of gels with the magnetic properties of magnetic nanoparticles (usually magnetite or maghemite) and respond quickly to the external magnetic field. Apart from their unique magnetic properties, nanocomposite gel scaffolds with embedded magnetite/maghemite nanoparticles have exhibited superior mechanical, rheological and electrical properties compared to scaffold gels without nanoparticle reinforcement, better biocompatibility, low cytotoxicity, and demonstrated antibacterial properties [ 1 , 2 , 3 , 4 ]. Furthermore, iron oxide nanoparticles have been shown to promote osteogenic differentiation of stem cells [ 8 , 9 , 10 ] and can provide the transduction of the dynamic mechanical stimulation required for bone formation [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Rheological, Microstructural and Thermal Properties of Magnetic Poly(Ethylene Oxide)/Iron Oxide Nanocomposite Hydrogels Synthesized Using a One-Step Gamma-Irradiation Method

et al. 2020

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Magnetic polymer gels are a new promising class of nanocomposite gels. In this work, magnetic PEO/iron oxide nanocomposite hydrogels were synthesized using the one-step -irradiation method starting from poly(ethylene oxide) (PEO) and iron(III) precursor alkaline aqueous suspensions followed by simultaneous crosslinking of PEO chains and reduction of Fe(III) precursor. -irradiation dose and concentrations of Fe3+, 2-propanol and PEO in the initial suspensions were varied and optimized. With 2-propanol and at high doses magnetic gels with embedded magnetite nanoparticles were obtained, as confirmed by XRD, SEM and Mössbauer spectrometry. The quantitative determination of -irradiation generated Fe2+ was performed using the 1,10-phenanthroline method. The maximal Fe2+ molar fraction of 0.55 was achieved at 300 kGy, pH = 12 and initial 5% of Fe3+. The DSC and rheological measurements confirmed the formation of a well-structured network. The thermal and rheological properties of gels depended on the dose, PEO concentration and initial Fe3+ content (amount of nanoparticles synthesized inside gels). More amorphous and stronger gels were formed at higher dose and higher nanoparticle content. The properties of synthesized gels were determined by the presence of magnetic iron oxide nanoparticles, which acted as reinforcing agents and additional crosslinkers of PEO chains thus facilitating the one-step gel formation.

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Polyacrylamide ferrogels with embedded maghemite nanoparticles for biomedical engineering

Cited by 46 publications

References 44 publications

Reduction of T2 Relaxation Rates due to Large Volume Fractions of Magnetic Nanoparticles for All Motional Regimes

Reduction of T2 Relaxation Rates due to Large Volume Fractions of Magnetic Nanoparticles for All Motional Regimes

Water-Based Suspensions of Iron Oxide Nanoparticles with Electrostatic or Steric Stabilization by Chitosan: Fabrication, Characterization and Biocompatibility

Rheological, Microstructural and Thermal Properties of Magnetic Poly(Ethylene Oxide)/Iron Oxide Nanocomposite Hydrogels Synthesized Using a One-Step Gamma-Irradiation Method

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