Polyacetal and poly(ortho ester)–poly(ethylene glycol) graft copolymer thermogels: Preparation, hydrolysis and FITC-BSA release studies

Schacht, Etienne; Toncheva, Veska; Vandertaelen, Kristin; Heller, Jorge

doi:10.1016/j.jconrel.2006.07.026

Cited by 52 publications

(54 citation statements)

References 14 publications

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“…Polyacetal grafted with MPEG was prepared, to make a thermogelling hydrogel. [74] When a 15% graft ratio of MPEG and a 5% graft ratio of poly(orthoester) were introduced onto the polyacetal backbone, the resulting polymer in aqueous solutions (25 wt.-%) underwent a sol-to-gel transition at 34 8C. PEG-poly(ethyl-2-cyanoacrylate) (PEG-PEC) was synthesized by addition polymerization.…”

Section: Other Thermosensitive Block Copolymersmentioning

confidence: 99%

Injectable Biodegradable Hydrogels

Nguyen

Lee

2010

Macromolecular Bioscience

416

343

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Injectable biodegradable copolymer hydrogels, which exhibit a sol–gel phase transition in response to external stimuli, such as temperature changes or both pH and temperature (pH/temperature) alterations, have found a number of uses in biomedical and pharmaceutical applications, such as drug delivery, cell growth, and tissue engineering. These hydrogels can be used in simple pharmaceutical formulations that can be prepared by mixing the hydrogel with drugs, proteins, or cells. Such formulations are administered in a straightforward manner, through site‐specific control of release behavior, and the hydrogels are compatible with biological systems. This review will provide a summary of recent progress in biodegradable temperature‐sensitive polymers including polyesters, polyphosphazenes, polypeptides, and chitosan, and pH/temperature‐sensitive polymers such as sulfamethazine‐, poly(β‐amino ester)‐, poly(amino urethane)‐, and poly(amidoamine)‐based polymers. The advantages of pH/temperature‐sensitive polymers over simple temperature‐sensitive polymers are also discussed. A perspective on the future of injectable biodegradable hydrogels is offered.magnified image

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Section: Other Thermosensitive Block Copolymersmentioning

confidence: 99%

Injectable Biodegradable Hydrogels

Nguyen

Lee

2010

Macromolecular Bioscience

416

343

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“…153 A primary amine was protected until after the synthesis of the back bone chain and then a NHS ester reaction was utilized to attach the bethylene glycol side chains to the active amine sites. The resulting graft copolymers had tuneable release profiles from 14-80 days depending on polyacetal composition and pH.…”

Section: Graft Copolymersmentioning

confidence: 99%

Hierarchically Ordered Montmorillonite Block Copolymer Brushes

2010

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“…Polyacetal and polyketal based biomaterials can take advantage of the fact that the local environment within a tumor has a lower pH than the surrounding tissue, and therefore induce the release of drugs at these sites, due to pH dependent degradation (24,65). A number of studies have recently shown that degradation and drug release rates are accelerated when in a low pH environment (23,24,66,67). This targeted release allows the carrier to remain in the blood and not release the therapeutic drug until it is taken up into the tumor, significantly decreasing administration of the drug to local healthy tissues (66).…”

Section: Polyacetals and Polyketalsmentioning

confidence: 99%

“…For example, synthetic polymers based upon degradable units such as acetals, cyclic acetals, and ketals have been developed and shown to degrade via hydrolysis to produce hydroxyl and carbonyl terminals (22)(23)(24). While the specific chemical structure of each degradation product is monomer and reaction specific, the products are typically alcohols, carbonyls, aldehydes, and ketones.…”

Section: Introductionmentioning

confidence: 99%

Recent Developments in Cyclic Acetal Biomaterials for Tissue Engineering Applications

2008

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Abstract. At an ever increasing pace, synthetic biomaterials are being developed with specific functionalities for tissue engineering applications. These biomaterials possess properties including biocompatibility, mechanical strength, and degradation as well as functionalities such as specific cell adhesion and directed cell migration. However, synthetic polymers are often not completely biologically inert and may non-specifically react with the surrounding in vivo environment. An example of this reactivity is the release of acidic degradation products from hydrolytically degradable polymers based upon an ester moiety. In order to address this concern, a novel class of biomaterials based upon a cyclic acetal unit has been developed. Scaffolds suitable for the replacement of both hard and soft tissues have been successfully fabricated from cyclic acetals and a detailed characterization of scaffold properties has been performed. Cyclic acetal based biomaterials have also been used to repair bone defects and promote bone growth, displaying a minimal inflammatory response. This review will discuss the most recent research of current biomaterials and cyclic acetals, and particularly focus on the tissue engineering applications of these materials. Finally, this review will also briefly discuss polyacetals and polyketals for drug delivery applications.

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Polyacetal and poly(ortho ester)–poly(ethylene glycol) graft copolymer thermogels: Preparation, hydrolysis and FITC-BSA release studies

Cited by 52 publications

References 14 publications

Injectable Biodegradable Hydrogels

Injectable Biodegradable Hydrogels

Hierarchically Ordered Montmorillonite Block Copolymer Brushes

Recent Developments in Cyclic Acetal Biomaterials for Tissue Engineering Applications

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