Poly (ε-caprolactone) Microsphere Decorated with Nano-ZnO Based Phytoformulation: A Promising Antimicrobial Agent

Snigdha, S.; Rahul, M.T.; Kalarikkal, Nandakumar; Thomas, Sabu; Radhakrishnan, E. K.

doi:10.1007/s10904-019-01114-2

Cited by 9 publications

(2 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In medicine, ZnO NMs have been reported as an anticancer, bactericidal, fungicidal, antidiabetic and antiin ammatory agent. ZnO NMs have also been approved by United States Food and Drug Administration (FDA) as biocompatible antimicrobial agents [11,22]. ZnO, as a transition MeO, semiconductor with high binding energy has highly oxidative property producing ROS (Fenton reaction) as a pathway of antibacterial function.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial performance of curcumin loaded polycyclodextrin-coated zinc oxide nanomaterials in photodynamic therapy against Enterococcus faecalis

Gholibegloo¹,

Akbari²,

Torshabi³

et al. 2022

Preprint

View full text Add to dashboard Cite

Antimicrobial photodynamic therapy (aPDT) is a high potential strategy for the treatment of microbial infections in endodontics. In this study, a novel antibacterial agent was designed and prepared based on the two morphologies of zinc oxide nanomaterials (NMs) as ZnO nanosphere (ZnOS) and ZnO nanorod (ZnOR). Their surfaces were coated with carnosine (CAR)-functionalized polycyclodextrin (ZnO@PCD-CAR) for higher payload of curcumin (CUR) as a photosensitizer (PS). This system was characterized using FT-IR, XRD, TGA, FE-SEM, zeta potential analysis and UV-visible spectroscopy. The colony forming unit (CFU) assay was carried out to evaluate the antimicrobial properties of the nanoformulations againts Enterococcus faecalis (E. Faecalis). The target products (ZnOS@PCD-CAR/CUR and ZnOR@PCD-CAR/CUR) exhibited a light stability approximately by 2.9 and 2.8 fold, respectively, higher than the free CUR. Compared to the bare CUR, these materials indicated more stability againts pH variations. ZnOS@PCD-CAR/CUR and ZnOR@PCD-CAR/CUR NMs-mediated aPDT, significantly declined the count of E. Faecalis strains about 1.5 and 2 log (P < 0.05). Due to the high CUR loading, proper stability and significant inhibitory effects against E. Faecalis, ZnO@PCD-CAR/CUR could be considered as a promising antimicrobial agent in aPDT for efficient treatment of root canal infections.

show abstract

Section: Introductionmentioning

confidence: 99%

Antibacterial performance of curcumin loaded polycyclodextrin-coated zinc oxide nanomaterials in photodynamic therapy against Enterococcus faecalis

Gholibegloo¹,

Akbari²,

Torshabi³

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Ag nanoparticles also exhibit good third order nonlinear optical (NLO) properties and showed their application as optical limiter [28]. Bio synthesized Ag NPs show better optical limiting properties even though the bio molecules cap the Ag NPs [29][30][31][32].…”

Section: Introductionmentioning

confidence: 99%

Optical and biomedical applications of eco-friendly biosynthesized silver nano spheres using zingiber officinale root extract

Ramya¹,

Jyothi

Vardhan

et al. 2020

Nano Ex.

View full text Add to dashboard Cite

Eco-friendly bio-compatible silver nanoparticles (Ag NPs) were successfully synthesized using Zingiber officinale extract in a simple green route at room temperature. The phytoconstituents present in Zingiber officinale (Z. officinale) extract act as reducing and stabilizing agents. The size and crystallinity of spherical Ag NPs were confirmed through transmission electron microscopy (TEM) and X-ray diffraction (XRD) studies. The formation of silver nanoparticles was also confirmed from the UV-vis and FTIR spectra. Luminescence properties of europium (Eu) and samarium (Sm) complexes in the presence of silver were studied. The intensity of luminescence from Eu and Sm complexes were found to get enhanced or quenched with their concentrations in Ag NPs. Interesting nonlinear optical properties exhibited by Ag NPs were observed in the Z-scan experiment suggesting that they can be used as optical limiters for the picosecond (ps) time scale green laser. Silver nanoparticles were tested against colon cancer (HCT116) cells in vitro by MTT assay and they exhibited smaller IC 50 values with better inhibition efficiency. Ag NPs induced apoptosis through the activation of Reactive oxygen species (ROS) and Caspase-3 pathways. Antibacterial activity of Ag NPs was analysed against Acinetobacter baumannii (A. baumannii) and Staphylococcus aureus (S. aureus) and they were found to be efficient in inhibiting the bacteria. The results indicate that the biosynthesized eco-friendly nanoparticles having high stability can lead to many applications such as good luminescence enhancement, optical limiting characteristics, anticancerous and antibacterial properties in optics and biomedicine.

show abstract

The Need for Engineering Antimicrobial Surfaces

Snigdha¹,

Kalarikkal²,

Thomas³

et al. 2020

Engineered Antimicrobial Surfaces

View full text Add to dashboard Cite

Poly (ε-caprolactone) Microsphere Decorated with Nano-ZnO Based Phytoformulation: A Promising Antimicrobial Agent

Cited by 9 publications

References 36 publications

Antibacterial performance of curcumin loaded polycyclodextrin-coated zinc oxide nanomaterials in photodynamic therapy against Enterococcus faecalis

Antibacterial performance of curcumin loaded polycyclodextrin-coated zinc oxide nanomaterials in photodynamic therapy against Enterococcus faecalis

Optical and biomedical applications of eco-friendly biosynthesized silver nano spheres using zingiber officinale root extract

The Need for Engineering Antimicrobial Surfaces

Contact Info

Product

Resources

About