Poly(α-hydroxy acid) based polymers: A review on material and degradation aspects

Ginjupalli, Kishore; Shavi, Gopal Venkat; Averineni, Ranjith Kumar; Bhat, Meghashyam; Udupa, N.; Upadhya, P. Nagaraja

doi:10.1016/j.polymdegradstab.2017.08.024

Cited by 76 publications

(70 citation statements)

References 157 publications

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“…This low molar mass may facilitate the dispersion of PLGA within the soft silicone oil. Beside this advantage, it is known that low molar mass polyesters degrade faster in water than higher molar mass polymers [35], which is a required condition in our study. The D,L-lactide was preferred to the D or L enantiomers as the polymers of the latter ones are semi-crystalline polymers whereas the polymerized racemic form is amorphous due to the irregularities in the polymer main chain [36].…”

Section: Synthesis Of Poly(dl-lactide-co-glycolide) (Plga)mentioning

confidence: 99%

Water erodible coatings based on a hydrolyzable PDMS/polyester network

Gevaux

Lejars

Margaillan

et al. 2018

Materials Today Communications

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HAL is a multidisciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.

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Section: Synthesis Of Poly(dl-lactide-co-glycolide) (Plga)mentioning

confidence: 99%

Water erodible coatings based on a hydrolyzable PDMS/polyester network

Gevaux

Lejars

Margaillan

et al. 2018

Materials Today Communications

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“…The PLC-only coating had a slow degradation rate ( Figure 7) due to its material composition. PLC is a copolymer of poly-l-lactide (PLLA) and poly-ε-carproactone (PCL), and typically PLLA and PCL have a 3-7 year degradation cycle [18]. The initial sharp decrease in mass was mainly due to the burst release of antibiotics ( Figure 8A-B and Figure 9C).…”

Section: Degradation and Antibiotic Release Rate Of Double Coatingsmentioning

confidence: 99%

“…However, this rapid release rate would not sufficiently tackle early infections, which typically onset after approximately 2 weeks [2]. The release rate of antibiotics can be tailored to match the degradation rate of the polylactide matrix by altering the copolymerized monomers, molecular weight, and crystallinity [18]. Although resorbable materials embedded with antibiotics have been investigated as coatings on the surface of implants [19], the additional layer often presents complications such as substantially increasing the thickness of the device, providing a smooth coating leading to implant instability, and peeling off of the coating from the device [20].…”

Section: Introductionmentioning

confidence: 99%

Implant Coating Manufactured by Micro-Arc Oxidation and Dip Coating in Resorbable Polylactide for Antimicrobial Applications in Orthopedics

Cao

Tian²,

Dong³

et al. 2019

Coatings

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Prophylaxis and the treatment of implant-related infections has become a key focus area for research into improving the outcome of orthopedic implants. Functional resorbable coatings have been developed to provide an antimicrobial surface on the implant and reduce the risk of infection. However, resorbable coatings developed to date still suffer from low adhesive strength and an inadequate release rate of antibiotics. This study presents a novel double-coating of micro-arc oxidation and resorbable polylactide copolymer on a Ti-6Al-4V implant with the aim of reducing the risk of infection post-implantation. The adhesive strength, rate of coating degradation, and antibiotic release rate were investigated. A key finding was that the micro-arc oxidation coating with the addition of antibiotics increased the adhesive strength of the poly-l-lactide-co-ε-caprolactone (PLC) coatings. The adhesive strength was influenced by the concentration of the PLC solution, the surface structure of the titanium substrate, and the composition of the coatings. The antibiotics blended into the PLC coating had a release cycle of approximately 10 days, which would be long enough to reduce the risk of developing an infection after implantation. The double coatings presented in this study have an excellent potential for reducing the incidence and severity of implants-related early infections.

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“…Biodegradable synthetic polymers show the advantage of the easy modification of their composition with following change of their chemical, physical and mechanical properties [24,25]. In biomedical field, these materials are currently used alone or in combination with devices for bone fracture repair, ligament reconstruction, or surgical dressings [26,27].…”

Section: Introductionmentioning

confidence: 99%

Mineral-Doped Poly(L-lactide) Acid Scaffolds Enriched with Exosomes Improve Osteogenic Commitment of Human Adipose-Derived Mesenchymal Stem Cells

et al. 2020

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Exosomes derived from mesenchymal stem cells are extracellular vesicles released to facilitate cell communication and function. Recently, polylactic acid (PLA), calcium silicates (CaSi), and dicalcium phosphate dihydrate (DCPD) have been used to produce bioresorbable functional mineral-doped porous scaffolds-through thermally induced phase separation technique, as materials for bone regeneration. The aim of this study was to investigate the effect of mineral-doped PLA-based porous scaffolds enriched with exosome vesicles (EVs) on osteogenic commitment of human adipose mesenchymal stem cells (hAD-MSCs). Two different mineral-doped scaffolds were produced: PLA-10CaSi-10DCPD and PLA-5CaSi-5DCPD. Scaffolds surface micromorphology was investigated by ESEM-EDX before and after 28 days immersion in simulated body fluid (HBSS). Exosomes were deposited on the surface of the scaffolds and the effect of exosome-enriched scaffolds on osteogenic commitment of hAD-MSCs cultured in proximity of the scaffolds has been evaluated by real time PCR. In addition, the biocompatibility was evaluated by direct-contact seeding hAD-MSCs on scaffolds surface-using MTT viability test. In both formulations, ESEM showed pores similar in shape (circular and elliptic) and size (from 10–30 µm diameter). The porosity of the scaffolds decreased after 28 days immersion in simulated body fluid. Mineral-doped scaffolds showed a dynamic surface and created a suitable bone-forming microenvironment. The presence of the mineral fillers increased the osteogenic commitment of hAD-MSCs. Exosomes were easily entrapped on the surface of the scaffolds and their presence improved gene expression of major markers of osteogenesis such as collagen type I, osteopontin, osteonectin, osteocalcin. The experimental scaffolds enriched with exosomes, in particular PLA-10CaSi-10DCPD, increased the osteogenic commitment of MSCs. In conclusion, the enrichment of bioresorbable functional scaffolds with exosomes is confirmed as a potential strategy to improve bone regeneration procedures.

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Poly(α-hydroxy acid) based polymers: A review on material and degradation aspects

Cited by 76 publications

References 157 publications

Water erodible coatings based on a hydrolyzable PDMS/polyester network

Water erodible coatings based on a hydrolyzable PDMS/polyester network

Implant Coating Manufactured by Micro-Arc Oxidation and Dip Coating in Resorbable Polylactide for Antimicrobial Applications in Orthopedics

Mineral-Doped Poly(L-lactide) Acid Scaffolds Enriched with Exosomes Improve Osteogenic Commitment of Human Adipose-Derived Mesenchymal Stem Cells

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