Poly(vinylpyrrolidone)-doped nitric oxide-releasing xerogels as glucose biosensor membranes

Schoenfisch, Mark H.; Rothrock, Aaron R.; Shin, Jae Ho; Polizzi, Mark A.; Brinkley, Michael F.; Dobmeier, Kevin P.

doi:10.1016/j.bios.2006.01.012

Cited by 21 publications

(28 citation statements)

References 27 publications

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“…Indeed, sensor response effects due to NO release and changes in membrane permeability (water uptake) were shown to significantly decrease during this preconditioning period (data not shown). Response and calibration curves were obtained by injecting 1 M glucose aliquots into 30 mL PBS at room temperature under constant stirring and an applied potential of +0.6 V vs. Ag/AgCl (Schoenfisch et al, 2006; Shin et al, 2004). Permeability (

{italicP}_{i}^{e}

) was defined electrochemically as the ratio of peak current at the hybrid sol–gel/polyurethane glucose sensor (Δ I x ) and bare platinum electrode (Δ I b ) response at either 0.79 mM H 2 O 2 (

P_{H_{2} O_{2}}^{e}

) or air saturated solution (

P_{O_{2}}^{e}

) (Schoenfisch et al, 2006; Shin et al, 2008).…”

Section: Methodsmentioning

confidence: 99%

Fabrication of nitric oxide-releasing polyurethane glucose sensor membranes

Koh

Riccio

Sun

et al. 2011

Biosensors and Bioelectronics

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Despite clear evidence that polymeric nitric oxide (NO) release coatings reduce the foreign body response (FBR) and may thus improve the analytical performance of in vivo continuous glucose monitoring devices when used as sensor membranes, the compatibility of the NO release chemistry with that required for enzymatic glucose sensing remains unclear. Herein, we describe the fabrication and characterization of NO-releasing polyurethane sensor membranes using NO donor-modified silica vehicles embedded within the polymer. In addition to demonstrating tunable NO release as a function of the NO donor silica scaffold and polymer compositions and concentrations, we describe the impact of the NO release vehicle and its release kinetics on glucose sensor performance.

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{italicP}_{i}^{e}

) was defined electrochemically as the ratio of peak current at the hybrid sol–gel/polyurethane glucose sensor (Δ I x ) and bare platinum electrode (Δ I b ) response at either 0.79 mM H 2 O 2 (

P_{H_{2} O_{2}}^{e}

) or air saturated solution (

P_{O_{2}}^{e}

) (Schoenfisch et al, 2006; Shin et al, 2008).…”

Section: Methodsmentioning

confidence: 99%

Fabrication of nitric oxide-releasing polyurethane glucose sensor membranes

Koh

Riccio

Sun

et al. 2011

Biosensors and Bioelectronics

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“…The range of biomedical applications for NO may necessitate multiple formulations including gaseous NO, low molecular weight molecules, and macromolecular particles, gels and coatings. For example, polymeric device coatings capable of releasing NO in a controlled manner have been shown to decrease bacterial infection and improve tissue integration and/or blood compatibility for subcutaneous glucose sensors, 7, 39 orthopedic devices, 40, 41 and vascular stents. 42 Macromolecular NO release scaffolds are also being developed as stand-alone therapeutics against pathogens 43, 44 and cancer, 10 with much of their efficacy related to their ability to deliver large NO payloads directly to cells.…”

Section: Reporting Nitric Oxide Releasementioning

confidence: 99%

“…3 As such, therapeutics that either regulate NOS activity or produce NO exogenously have become an important research area. Indeed, the number of scaffolds that chemically store and deliver NO include NO-releasing proteins, 4 nanoparticles, 5, 6 and polymers 7, 8 (see Nitric Oxide Release Part I: Macromolecular Scaffolds). These exogenous sources of NO have been investigated as potential medicinal agents for cardiovascular, 2, 9 cancer, 10 antibacterial, 11, 12 and wound healing 11, 13 therapies as discussed in Nitric Oxide Release Part II: Therapeutic Applications.…”

Section: Introductionmentioning

confidence: 99%

Nitric oxide release: Part III. Measurement and reporting

2012

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Summary Nitric oxide’s expansive physiological and regulatory roles have driven the development of therapies for human disease that would benefit from exogenous NO administration. Already a number of therapies utilizing gaseous NO or NO donors capable of storing and delivering NO have been proposed and designed to exploit NO’s influence on the cardiovascular system, cancer biology, the immune response, and wound healing. As described in Nitric Oxide Release Part I: Macromolecular Scaffolds and Part II: Therapeutic Applications, the preparation of new NO-release strategies/formulations and the study of their therapeutic utility are increasing rapidly. However, comparison of such studies remains difficult due to the diversity of scaffolds, NO measurement strategies, and reporting methods employed across disciplines. This tutorial review highlights useful analytical techniques for the detection and measurement of NO. We also stress the importance of reporting NO delivery characteristics to allow appropriate comparison of NO between studies as a function of material and intended application.

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“…glucose) 32,33 sensors and biosensors. While the diffusion of NO through these materials was rapid, the intrinsic permeability of O 2 , a highly nonpolar molecule, was quite low.…”

Section: Mn II (No)tpps Formation In Xerogel Filmsmentioning

confidence: 99%

Xerogel Optical Sensor Films for Quantitative Detection of Nitroxyl

2008

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Xerogel films were synthesized via sol-gel chemistry to fabricate optical nitroxyl (HNO) sensors. Selective detection of HNO in solution was achieved by monitoring the rates of manganese(III) meso-tetrakis(4-sulfonatophenyl) porphyrinate (Mn III TPPS) reductive nitrosylation in the anaerobic interior of aminoalkoxysilane-derived xerogel films. Nitroxyl permeability in sensor films deposited in round-bottom 96-well plates was enhanced via incorporation of trimethoxysilylterminated poly(amidoamine-organosilicon) (PAMAMOS) dendrimers in the xerogel network. The selectivity of Mn III TPPS for HNO, the overall sensitivity, and the working dynamic range of the resulting sensors were characterized. The HNO-sensing microtitre plates were used to quantify pH-dependent HNO generation by the recently described HNO-donor sodium-1-(isopropylamino)diazene-1-ium-1,2-diolate (IPA/NO), and compare HNO-production efficiency between IPA/NO and Angeli's salt, a traditional HNO-donor.

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Poly(vinylpyrrolidone)-doped nitric oxide-releasing xerogels as glucose biosensor membranes

Cited by 21 publications

References 27 publications

Fabrication of nitric oxide-releasing polyurethane glucose sensor membranes

Fabrication of nitric oxide-releasing polyurethane glucose sensor membranes

Nitric oxide release: Part III. Measurement and reporting

Xerogel Optical Sensor Films for Quantitative Detection of Nitroxyl

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