Poly(vinylpyrrolidone): Configurational assignments by one‐ and two‐dimensional NMR spectroscopy

Dutta, Kaushik; Brar, A. S.

doi:10.1002/(sici)1099-0518(19991101)37:21<3922::aid-pola7>3.3.co;2-a

Cited by 18 publications

(36 citation statements)

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“…The 13 C and 1 H spectra for both PVA and PVP contained several overlapping peaks, and 2D homonuclear and heteronuclear COSY experiments were required to assign all the peaks in the spectra. The proton and carbon peak assignments for these two polymers were identical to those described in previous articles28, 29 and, therefore, are not reported here. The number of broad, overlapping peaks also made the NOSY experiments difficult to interpret, and no significant through‐space association between PVA and PVP could be discerned with this method (data not shown).…”

Section: Resultssupporting

confidence: 61%

Biocompatible polymer blends: Effects of physical processing on the molecular interaction of poly(vinyl alcohol) and poly(vinyl pyrrolidone)

Jones

Martin

Royall

et al. 2005

J of Applied Polymer Sci

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Blending is a very effective method for manufacturing new polymeric materials; however, the process used to combine two polymers can influence the physicochemical properties of the final product. As such, the aim of this study was to investigate how the rapid removal of a solvent from a composite by the spray drying of partially hydrolyzed poly(vinyl alcohol) (PVA)/poly(vinyl pyrrolidone) (PVP) altered the solid-state properties of the material compared to casting the blend within a film. Although thermal analysis showed that PVP acted as a plasticizer, reducing the melting point of PVA, spray drying the product rather than using a film-casting procedure improved its solid-state stability (increasing the glass transition) and resulted in the formation of a second crystalline phase within the material. Spectroscopic studies suggested that the manufacturing-induced variance in the solid-state properties of the PVA/PVP blends originated from structural differences in the composite caused by the processing method employed to form the blend. Although blending should still be considered a viable method of generating novel polymeric material, this study illustrated that through careful manipulation of the actual manufacturing process, the solid-state properties of the product can be altered. This could open a whole range of novel applications for traditionally used polymer composites.

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Section: Resultssupporting

confidence: 61%

Biocompatible polymer blends: Effects of physical processing on the molecular interaction of poly(vinyl alcohol) and poly(vinyl pyrrolidone)

Jones

Martin

Royall

et al. 2005

J of Applied Polymer Sci

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“…Further increasing the VP content in copolymers definitely resulted in more DMSO-and water-soluble products, however the copolymers with higher VP content could not complex with DNA according to electrophoresis results, thus leading to poor transfection results. 1 H NMR (DMSO-d 6 , Varian INOVA500) confirmed the formation of PVP and copolymers: VDT (NH 2 , d 6.5 ppm) and VP (CH, d 3.56-3.7 ppm; 4 CH 2 , d 3.16 ppm; 2 CH 2 , d 2.06-2.22 ppm; 3 CH 2 , d 1.87 ppm; CH 2 , d 1.31-1.63 ppm) [31]. Molar composition ratios of copolymers were estimated from the peak areas of NH 2 in VDT and 4 CH 2 in VP.…”

Section: Methodsmentioning

confidence: 99%

Design of Poly(vinyldiaminotriazine)‐Based Nonviral Vectors via Specific Hydrogen Bonding with Nucleic Acid Base Pairs

Cao

Liu

Liang

et al. 2006

Adv Funct Materials

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A novel gene transfer system that complexes plasmid DNA (pDNA) through complementary hydrogen bonding of guests with base pairs is reported. Poly(vinyldiaminotriazine) (PVDT) homopolymer and its copolymers with poly(1‐vinyl‐2‐pyrrolidone) are synthesized via conventional radical random polymerization, and water‐soluble fractions are collected. These PVDT‐based polymers efficiently complex pDNA and displace ethidium bromide (EB) in EB‐intercalated pDNA solutions because of the hydrogen‐bonding‐induced constrained state of pDNA. It is also found that upon complexation, pDNA seems to undergo B–C conformation change and circular dichroism spectra assumed a polymer‐and‐salt‐induced (psi)‐type pattern that is rationally ascribed to a certain change in the high‐order structure of DNA condensates. Transmission electron microscopy presented several morphologies of spheres and toroids within aggregates ≥ 100 nm, resembling DNA condensation induced by cationics. In transfection studies using pDNA‐encoding luciferase or enhanced green fluorescent protein, this system could efficiently transfect COS‐1 cells. Compared to the commercial polycation system, ExGen 500, these H‐bonding vectors display several merits such as higher transfection efficiency, lower cytotoxicity, better serum compatibility, and stability in the presence of bovine serum albumin (BSA). The results suggest that PVDT‐based polymers are superior to polycation counterparts with regard to their potential in vivo applications.

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“…Dais et al [49] have reported the complete assignments of proton and carbon spectra of poly(N-vinylcarbazole) (PVK) by employing a number of modern gradient 2D NMR experiments like COSY, TOCSY, HMQC, and HMBC. Brar and Dutta [50] have assigned the stereochemical structure of poly(N-vinyl-2-pyrrolidone) using 1D and 2D NMR. Methine and methylene carbon resonances were assigned up to pentad and tetrad level configurational sequences by 2D HSQC/TOCSY experiments.…”

Section: Nmr Of Homopolymersmentioning

confidence: 99%

Two-dimensional NMR studies of acrylate copolymers

Brar

Goyal

Hooda

2009

Pure and Applied Chemistry

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High-resolution NMR spectroscopy is the most versatile, reliable, and generally acceptable technique for the determination of the microstructure of polymers. 2D NMR techniques, along with 1D NMR, have more potential to study absolute configurational assignments and sequence distribution of copolymers. Physical and chemical properties of polymers are influenced fundamentally by their microstructure. We discuss the detailed microstructure analysis of a large number of homopolymers, copolymers, and terpolymers. 2D NMR study of poly(methyl methacrylate) (PMMA), poly(methyl acrylate) (PMA), and poly(methacrylonitrile) (PMAN) is discussed in this article. In addition to homopolymers, 2D heteronuclear single-quantum coherence (HSQC), total correlation spectroscopy (TOCSY), and heteronuclear multiple-bond correlation (HMBC) study of different copolymers such as poly(methyl methacrylate-co-methyl acrylate), poly(styrene-co-methyl methacrylate), and poly(methyl methacrylate-co-methacrylonitrile) have also been reported here. This in turn helps in microstructural analysis of terpolymers such as poly(methacrylonitrile-co-styrene-co-methyl methacrylate), poly(acrylonitrile-co-methyl methacrylate-comethyl acrylate), and poly(ethylene-co-vinyl acetate-co-carbon monoxide).

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Poly(vinylpyrrolidone): Configurational assignments by one‐ and two‐dimensional NMR spectroscopy

Cited by 18 publications

References 0 publications

Biocompatible polymer blends: Effects of physical processing on the molecular interaction of poly(vinyl alcohol) and poly(vinyl pyrrolidone)

Biocompatible polymer blends: Effects of physical processing on the molecular interaction of poly(vinyl alcohol) and poly(vinyl pyrrolidone)

Design of Poly(vinyldiaminotriazine)‐Based Nonviral Vectors via Specific Hydrogen Bonding with Nucleic Acid Base Pairs

Two-dimensional NMR studies of acrylate copolymers

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