Poly(vinyl chloride) and Poly(e-caprolactone) Blends for Medical Use

Rusu, Mihai; Ursu, Mihaela; Rusu, Daniela

doi:10.1177/0892705706056463

Cited by 54 publications

(40 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…DSC analysis was performed on unloaded and loaded PCL fibrous matrices (Supplementary Figure 4) and the corresponding thermodynamic parameters (melting temperature of the polymer, T f and correspondent enthalpy change, Δ H ) are presented in Table 1. Unloaded PCL fibers presented the characteristic melting peak of the polymer, at around 57°C in agreement with other reports (Rusu et al, 2006). This temperature is maintained after inclusion of the bioactives in the polymeric matrix.…”

Section: Resultssupporting

confidence: 92%

Polymeric Electrospun Fibrous Dressings for Topical Co-delivery of Acyclovir and Omega-3 Fatty Acids

Costa

Ribeiro

Machado

et al. 2019

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Herpetic infections caused by Herpes simplex virus (HSV) are among the most common human infections, affecting more than two quarters of the world's population. The standard treatment for orofacial herpes is the administration of antiviral drugs, mainly acyclovir (ACV). However, current products are mostly based on semisolid formulations that have limited ability to promote drug skin penetration and tend to leak from the application site, thus showing reduced ability to sustain local drug residence. This work reports on the production of poly (ε-caprolactone) (PCL) fibrous matrices with ACV and omega-3 fatty acids (ω3) for application as dressings to the topical treatment of orofacial herpes. PCL fibrous matrices with the co-incorporated bioactive compounds were obtained by electrospinning and characterized regarding their morphology, chemical, physical, and mechanical properties. The potential use of the developed polymeric fibrous matrices for topical applications was evaluated by: (i) the release kinetics of the bioactive compounds; (ii) the occlusive factor of the fibrous mat; (iii) ACV skin permeation capacity; and (iv) the cytotoxicity in a keratinocyte cell line. PCL fibrous matrices loaded with the bioactive compounds presented a smooth morphology and a good balance between flexibility and hardness essential to be durable for handling, while having a desirable texture to be used comfortably. The fibrous mat also provided a sustained release of ACV during 96 h and improved the skin permeability of this drug (Kp = 0.00928 ± 0.000867 cm/h) presenting also high porosity (74%) and a water vapor transmission rate (WVTR) of 881 ± 91 g/m2day, essential to maintain moist and oxygen for faster healing of herpes lesions. Furthermore, cytotoxicity studies suggest that the fibrous mat are safe for topical application. Overall, the PCL based electrospun fibrous matrices with ACV and ω3 hereby described have the potential to be used as therapeutic bandage systems for the treatment of orofacial herpes.

show abstract

Section: Resultssupporting

confidence: 92%

Polymeric Electrospun Fibrous Dressings for Topical Co-delivery of Acyclovir and Omega-3 Fatty Acids

Costa

Ribeiro

Machado

et al. 2019

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

show abstract

“…In general, plasticisers can leach from the polymer matrix, as they are not covalently bonded to the polymer. There is also a risk of drugs in the body migrating into plastics, which could lead to drugs falling below the therapeutic threshold [77].…”

Section: Poly(vinyl Chloride)mentioning

confidence: 99%

Fused Deposition Modelling as a Potential Tool for Antimicrobial Dialysis Catheters Manufacturing: New Trends vs. Conventional Approaches

et al. 2019

View full text Add to dashboard Cite

The rising rate of individuals with chronic kidney disease (CKD) and ineffective treatment methods for catheter-associated infections in dialysis patients has led to the need for a novel approach to the manufacturing of catheters. The current process requires moulding, which is time consuming, and coated catheters used currently increase the risk of bacterial resistance, toxicity, and added expense. Three-dimensional (3D) printing has gained a lot of attention in recent years and offers the opportunity to rapidly manufacture catheters, matched to patients through imaging and at a lower cost. Fused deposition modelling (FDM) in particular allows thermoplastic polymers to be printed into the desired devices from a model made using computer aided design (CAD). Limitations to FDM include the small range of thermoplastic polymers that are compatible with this form of printing and the high degradation temperature required for drugs to be extruded with the polymer. Hot-melt extrusion (HME) allows the potential for antimicrobial drugs to be added to the polymer to create catheters with antimicrobial activity, therefore being able to overcome the issue of increased rates of infection. This review will cover the area of dialysis and catheter-related infections, current manufacturing processes of catheters and methods to prevent infection, limitations of current processes of catheter manufacture, future directions into the manufacture of catheters, and how drugs can be incorporated into the polymers to help prevent infection.

show abstract

“…The incorporation of PCL was found to significantly reduce the melt viscosity of the matrix, thus indicating that PCL provides a plasticizing effect which is to be expected owing to the low melt viscosity of the Virgin PCL in comparison to Virgin PEO. The plasticizing effect of PCL has been well documented in literature and PCL has been used as a replacement for di(2-ethylhexyl) phthalate (DEHP) in poly(vinyl) chloride (PVC) compositions intended for medical device applications [41]. Blend 3 and Blend 4 displayed a lower melt viscosity than that of Virgin PCL and this reduction in melt viscosity can be attributed to the inclusion of the lower molecular weight PCL (M w 37,000).…”

Section: Melt Flow Indexmentioning

confidence: 99%

Degradable Nanocomposites for Fused Filament Fabrication Applications

Healy

Waldron

Geever

et al. 2018

JMMP

View full text Add to dashboard Cite

There has been a substantial increase in the use and development of plastics over the last century. However, due to ever-diminishing petroleum feedstocks and growing concern for the environment, there has been a rise in the use of eco-friendly polymers affording similar properties to that of their depleting counterparts. Poly(ε-caprolactone) is one such polymer. This present study investigates the possibility of developing a degradable nanocomposite, suitable for fused filament fabrication, utilizing hot melt extrusion technology to blend poly(ε-caprolactone), poly(ethylene) oxide and the nanoclay halloysite at loadings of two and six weight percent. The extruded blends were characterized using common polymer testing techniques. The addition of poly(ε-caprolactone) to the poly(ethylene) oxide matrix provided a plasticizing effect which was apparent with the melt flow index and melting point of the blends reducing with an increase in poly(ε-caprolactone) content. Upon reinforcing the matrix with halloysite, there was a significant improvement in mechanical properties. The addition of halloysite significantly increased Young's modulus 11% and 25% when the loading was two and six percent respectively. Furthermore, it was also possible to produce a filament with the desired properties, diameter 1.75 mm, for fused filament fabrication, with subsequent studies required to evaluate their printability.

show abstract

Poly(vinyl chloride) and Poly(e-caprolactone) Blends for Medical Use

Cited by 54 publications

References 24 publications

Polymeric Electrospun Fibrous Dressings for Topical Co-delivery of Acyclovir and Omega-3 Fatty Acids

Polymeric Electrospun Fibrous Dressings for Topical Co-delivery of Acyclovir and Omega-3 Fatty Acids

Fused Deposition Modelling as a Potential Tool for Antimicrobial Dialysis Catheters Manufacturing: New Trends vs. Conventional Approaches

Degradable Nanocomposites for Fused Filament Fabrication Applications

Contact Info

Product

Resources

About