Poly(vinyl alcohol) gels for use as tissue phantoms in photoacoustic mammography

Kharine, Alexei; Manohar, Srirang; Seeton, Rosalyn; Kolkman, R.G.M.; Bolt, René A.; Steenbergen, Wiendelt; Mul, F.F.M. de

doi:10.1088/0031-9155/48/3/306

Cited by 166 publications

(127 citation statements)

References 25 publications

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“…The static layer is made of a poly(vinyl alcohol) (PVA) gel with polystyrene particles. In the past, PVA has been used to produce elastic [10] or viscoelastic [11] gels as optical tissue phantoms. The advantage of PVA is its solubility in water, so we can make phantoms of known scattering and absorption properties by adding polystyrene spheres and water-soluble dyes before gelation.…”

Section: Methodsmentioning

confidence: 99%

Effect of speckles on the depth sensitivity of laser Doppler perfusion imaging

Rajan¹,

Varghese²,

Leeuwen³

et al. 2007

Opt. Express

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A theoretical model is presented and experimentally validated that allows the prediction of the effect of speckles on the depth sensitivity of laser Doppler perfusion imaging. It is shown that the influence of speckles on depth sensitivity is large. In particular the sensitivity to particle motion in superficial layers is strongly beam diameter dependent: decreasing the beam diameter on the tissue surface increases the sensitivity to superficial motion to a much stronger extent than sensitivity to motion at a larger depth. This can be explained through the effect of beam diameter changes on the fractional coherence areas generated by photons with different penetration depths in the tissue.

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Section: Methodsmentioning

confidence: 99%

Effect of speckles on the depth sensitivity of laser Doppler perfusion imaging

Rajan¹,

Varghese²,

Leeuwen³

et al. 2007

Opt. Express

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“…Polyvinyl alcohol (PVA) was chosen since PVA phantoms are resilient and can be stored for a long time (Hassan and Peppas 2000). Further, the ultrasonic (Surry et al 2004), optical (Kharine et al 2003), mechanical (Fromageau et al 2003) and thermal (Sundararajan 1999) properties of polyvinyl alcohol are well characterized and the material is suitable for multi-modal imaging studies. Generally, the composite vascular phantoms in our studies contained an inclusion embedded into an otherwise homogeneous vessel wall.…”

Section: A Arterial Vessel Samplesmentioning

confidence: 99%

Remote Temperature Estimation in Intravascular Photoacoustic Imaging

Sethuraman

Aglyamov

Smalling

et al. 2008

Ultrasound in Medicine & Biology

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Intravascular photoacoustic (IVPA) imaging is based on the detection of laser-induced acoustic waves generated within the arterial tissue under pulsed laser irradiation. Generally, laser radiant energy levels are kept low (20 mJ/cm 2 ) during photoacoustic imaging to conform to general standards for safe use of lasers on biological tissues. However, safety standards in intravascular photoacoustic imaging are not yet fully established. Consequently, monitoring spatio-temporal temperature changes associated with laser-tissue interaction is important to address thermal safety of IVPA imaging. In this study we utilize the IVUS based strain measurements to estimate the laser induced temperature increase. Temporal changes in temperature were estimated in a phantom modeling a vessel with an inclusion. A cross-correlation based time delay estimator was used to assess temperature induced strains produced by different laser radiant energies. The IVUS based remote measurements revealed temperature increases of 0.7±0.3°C, 2.9±0.2 °C and 5.0±0.2 °C, for the laser radiant energies of 30 mJ/cm 2 , 60 mJ/cm 2 and 85 mJ/cm 2 respectively. The technique was then used in imaging of ex vivo samples of a normal rabbit aorta. For arterial tissues, a temperature elevation of 1.1°C was observed for a laser fluence of 60 mJ/cm 2 and lesser than 1°C for lower energy levels normally associated with IVPA imaging. Therefore, the developed ultrasound technique can be used to monitor temperature during IVPA imaging. Furthermore, the analysis based on the Arrhenius thermal damage model indicates no thermal injury in the arterial tissue; suggesting the safety of IVPA imaging

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“…[26][27][28][29] TMM phantoms bridge the gap in translational research without the need of direct experimentation on humans or animals. The phantoms designed with TMMS are essential for assessing different technologies, and for training and research.…”

Section: Introductionmentioning

confidence: 99%

“…Various kinds of TMMs have already been used in ultrasound research, such as gelatine, agar, silicone, and polyacrylamide (PAA) gel. [26][27][28][29] The key parameters in material characterization for ultrasound imaging include the acoustic velocity, the acoustic impedance, and the acoustical attenuation, while Young's modulus is an important parameter for elastography phantoms. Madsen et al 30 have demonstrated the use of TM phantoms for standardization of both ultrasound imaging of the prostate 26 and for elastographic imaging 18, 31 using agar and gelatine materials.…”

Section: Introductionmentioning

confidence: 99%

Tissue mimicking materials for the detection of prostate cancer using shear wave elastography: A validation study

et al. 2013

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Purpose: Quantification of stiffness changes may provide important diagnostic information and aid in the early detection of cancers. Shear wave elastography is an imaging technique that assesses tissue stiffness using acoustic radiation force as an alternate to manual palpation reported previously with quasistatic elastography. In this study, the elastic properties of tissue mimicking materials, including agar, polyacrylamide (PAA), and silicone, are evaluated with an objective to determine material characteristics which resemble normal and cancerous prostate tissue. Methods: Acoustic properties and stiffness of tissue mimicking phantoms were measured using compressional mechanical testing and shear wave elastography using supersonic shear imaging. The latter is based on the principles of shear waves generated using acoustic radiation force. The evaluation included tissue mimicking materials (TMMs) within the prostate at different positions and sizes that could mimic cancerous and normal prostate tissue. Patient data on normal and prostate cancer tissues quantified using biopsy histopathology were used to validate the findings. Pathologist reports on histopathology were blinded to mechanical testing and elastographic findings.

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Poly(vinyl alcohol) gels for use as tissue phantoms in photoacoustic mammography

Cited by 166 publications

References 25 publications

Effect of speckles on the depth sensitivity of laser Doppler perfusion imaging

Effect of speckles on the depth sensitivity of laser Doppler perfusion imaging

Remote Temperature Estimation in Intravascular Photoacoustic Imaging

Tissue mimicking materials for the detection of prostate cancer using shear wave elastography: A validation study

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